Qiuhong Xiong   Ph.D
	Associate professor   Doctoral Supervisor
	Email: qxiong@sxu.edu.cn

 

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Education Experience：

2011.10-2015.06 University of Cologne, Germany, PhD

2008.09-2011.06 Jilin University,China, Master

2004.09-2008.06 Shanxi Normal University,China, Bachelor

Work Experience：

2016.08-now Shanxi University, PI

2015.07-2016.03 University of Cologne, Postdoctor

Research Projects：

     Autophagy is the major lysosomal route for the turnover of cytoplasmic components. It involves the sequestration and transport of complete regions of the cytoplasm, including both soluble proteins and entire organelles within double-membrane vacuoles, to the lysosomal system for degradation and recycling by lysosomal hydrolases. It is a highly conserved proteolytic mechanism from yeast to man. Impairment of autophagy is thought to underlie the etiology of numerous diseases such as cancer, inflammation, infectious and neurodegenerative diseases. Our group recently focuses on:

1) Roles of autophagy in human diseases. Currently we are focused on the role of autophagy-related protein WDR45 in beta-propeller protein-associated neurodegeneration (BPAN).

2) Functions of ATGs in the crosstalk between autophagy and UPS using model organism Dictyostelium discoideum.

Grants:

1. The effect of iron accumulation on the neurons in substantia nigra. Shanxi Scholarship Council of China (Grant No. 2023-021).

2. Investigation into the molecular mechanism of mutation in WDR45 causes β-propeller protein-associated neurodegeneration by activating chaperone-mediated autophagy. National Natural Science Foundation of China (Grant No. 82271905).

3. Preclinical study of gene therapy technology for activated phosphoinositide 3-kinase-δ (APDS) syndrome, The Central Guidance on Local Science and Technology Development Fund of Shanxi Province (Grant No. YDZJSX2022A007).

4. Investigation into the mechanism of decreased proteasomal activity in ATG16 knock out cells in Dictyostelium discoideum, National Natural Science Foundation of China (Grant No. 31801972).

5. The role of autophagy-related protein WDR45 in beta-propeller protein-associated neurodegeneration. Natural Science Foundation of Shanxi Province, China (Grant No.201801D221248).

6. Functional analysis of transferrin receptor in brain iron accumulation in patients with beta-propeller protein-associated neurodegeneration. Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province, China (Grant No.2019L0096).

Publications:

Xiong Q*, Eichinger L*. Model organisms to study autophagy. Cells. 2023, 12(18):2212.

Chen G*, Wen D, Shen L, Feng Y, Xiong Q, Li P, Zhao Z*. Cepharanthine exerts antioxidant and anti-inflammatory effects in lipopolysaccharide (LPS)-induced macrophages and DSS-induced colitis mice. Molecules. 2023, 28(16):6070.

Xiong Q*, Feng R, Fisher S, Karow M, Stumpf M, Meßling S, Nitz L, Müller S, Clemen C, Song N, Li P, Wu C, Eichinger L*. Proteasomes of autophagy-deficient cells exhibit alterations in regulatory proteins and a marked reduction in activity. Cells. 2023, 12(11):1514.

Chen G, Yang Z, Wen D, Li P, Xiong Q, Wu C. Oridonin inhibits Mycobacterium marinum infection induced oxidative stress in vitro and in vivo. Pathogens. 2023, 12(6):799.

Xiong Q*, Sun H, Xing W, Li X, Chen G, Zhao Z, Wu C*, Li P*. WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism. Free Radical Biology and Medicine. 2023, 201:89-97.

Li P*, Lan W, Li J, Zhang Y, Xiong Q, Ye J, Wu C, Xiao H*. Identification and functional evaluation of a novel TBX4 mutation underlies small patella syndrome. International journal of molecular sciences. 2022, 23(4):2075.

Li P*, Wu Y, Wu H, Xiong Q, Zhao N, Chen G, Wu C, Xiao H*. Functional characterization of FH mutation c.557G>A underlies uterine leiomyomas. International journal of molecular sciences. 2022, 23(3):1452.

Wen D, Cui J, Li P, Xiong Q, Chen G*, Wu C*. Syndecan-4 assists Mycobacterium tuberculosis entry into lung epithelial cells by regulating the Cdc42, N-WASP, and Arp2/3 signaling pathways. Microbes and Infection, 2022:104931.

Zhang Y#, Xiao H#, Xiong Q, Wu C*, Li P*. Two novel hydroxymethylbilane synthase splicing mutations predispose to acute intermittent porphyria. International journal of molecular sciences. 2021, 22(20):11008. （# co-first author）

Xiong Q*, Song N, Li P, Fischer S, Konertz R, Wagle P, Glöckner G, Wu C*, Eichinger L*. RNAseq and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16. BMC Genomics. 2021, 22(1):444.

Zhao N, Yang Y, Li P, Xiong Q, Xiao H*, Wu C*. Identification of two novel compound heterozygous EIF2AK3 mutations underlying Wolcott-Rallison Syndrome in a Chinese family. Frontiers in Pediatrics. 2021, 9:679646.

Chen G, Yang Z, Wen D, Guo J, Xiong Q, Li P, Zhao L, Wang J*, Wu C*, Dong L*. Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis. Immunity, Inflammation and Disease. 2021, 9(3):959-970.

Xiong Q*, Li X, Li W, Chen G, Xiao H, Li P*, Wu C*. WDR45 mutation impairs the autophagic degradation of transferrin receptor and promotes ferroptosis. Frontiers in Molecular Biosciences. 2021, 8:645831.

Wang L, Xiong Q, Li P, Chen G, Tariq N, Wu C*. The negative charge of the 343 site is essential for maintaining physiological functions of CXCR4. BMC Molecular and Cell Biology. 2021, 22(1):8.

Han Y, Wang D, Guo J, Xiong Q, Li P, Zhou Y, Zhao B*. A novel splicing pathogenic variant in COL1A1 causing osteogenesis imperfecta (OI) type I in a Chinese family. Molecular Genetics & Genomic Medicine. 2020, 8(9):e1366.

Karow M, Fisher S, Meßling S, Konertz R, Riehl J, Xiong Q, Rijal R, Wagle P, Clemen CS, Eichinger L*. Functional characterization of the autophagy ATG12~5/16 complex in Dictyostelium discoideum. Cells. 2020, 9(5):1179.

Zhou Y, Li P*, Zhang Y, Xiong Q, Li C, Zhao Z, Wang Y, Xiao H*. Identification of a novel compound heterozygous IDUA mutation underlies Mucopolysaccharidoses type I in a Chinese pedigree. Molecular Genetics & Genomic Medicine. 2020, 8(1):e1058.

Xiong Q*, Yang M, Li P, Wu C*. Bacteria exploit autophagy for their own benefit. Infection and Drug Resistance. 2019, 12:3205-3215.

Xiong Q*, Li W, Li P, Zhao Z, Wu C*, Xiao H*. Functional evidence for a de novo mutation in WDR45 leading to BPAN in a Chinese girl. Molecular Genetics & Genomic Medicine. 2019, 7(9):e858.

Li P*, Zhang L, Xiong Q, Wang Z, Cui X, Zhou Y, Wang Y, Xiao H*, Wu C*. Functional evaluation of a novel GLA causative mutation in Fabry disease. Molecular Genetics & Genomic Medicine. 2019, 7(9):e864.

Li P*, Zhang L, Zhao N, Xiong Q, Zhou Y, Wu C*, Xiao H*. A novel α-Galactosidase A splicing mutation predisposes to Fabry disease. Frontiers in Genetics. 2019, 10:60.

Xiong Q, Li W, Li P, Yang M, Wu C*, Eichinger L*. The role of ATG16 in autophagy and the ubiquitin proteasome system. Cells. 2019, 8(1):2.

Xiao H, Xue Y, Liu Y, Li W, Zhao N, Xiong Q, Li P, Wu C*, Yang Y*. Novel de novo mutation in the autophagy gene WDR45 causes BPAN in a Chinese family. Journal of Molecular and Genetic Medicine. 2018, 12(4):381.

Xiong Q, Fischer S, Karow M, Müller R, Meßling S, Eichinger L*. ATG16 mediates the autophagic degradation of the 19S proteasomal subunits PSMD1 and PSMD2. European Journal of Cell Biology. 2018, 97(8):523-532.

Meβling S, Matthias J, Xiong Q, Fisher S, Eichinger L*. The two Dictyostelium discoideum autophagy 8 proteins have distinct autophagic functions. European Journal of Cell Biology. 2017, 96(4):312-324.

Mesquita A, Cardenal-Muñoz E, Dominguez E, Muñoz-Braceras S, Nuñez-Corcuera B, Phillips BA, Tábara LC, Xiong Q, Coria R, Eichinger L, Golstein P, King JS, Soldati T, Vincent O, Escalante R*. Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model. Autophagy. 2017, 13(1): 24-40.

Xiong Q, Ünal C, Matthias J, Steinert M, Eichinger L*. The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions. Open Biology. 2015, 5(4):150008.

Ma TH#, Xiong QH#, Yuan B, Jiang H, Gao Y, Xu JB, Liu SY, Ding Y*, Zhang GL, Zhao YM, Zhang JB*. Luteinizing hormone receptor splicing variants in bovine Leydig cells. Genetics and Molecular Research. 2012, 11(2):1721-30.（# co-first author）

Ma T, Jiang H, Gao Y, Zhao Y, Dai L, Xiong Q, Xu Y, Zhao Z, Zhang J*. Microarray analysis of differentially expressed microRNAs in non-regressed and regressed bovine corpus luteum tissue; microRNA-378 may suppress luteal cell apoptosis by targeting the interferon gamma receptor 1 gene. Journal of Applied Genetics. 2011, 52(4):481-6.