Peng Yang   Ph.D
	Lecturer   Master Supervisor
	Email: peng114011@sxu.edu.cn

Education and work experience

2004–2008 B.Sc. in Bioinformatics, Shanxi Agricultural University, Taigu, China

2008–2011 M.Sc. in Biochemistry and molecular biology, Shanxi University, Taiyuan, China

2012–2015 Ph.D. in Biochemistry and molecular biology, Shanxi University, Taiyuan, China

Academic Appointments

Since 2015–Lecturer of institute of biotechnology, Shanxi University

Main research fields

The mechanism of tumor metastasis, inflammation microenvironment and secretion regulation.

1. The mechanism of PKM2 in tumor inflammatory microenvironment

2. Screening and molecular mechanism of small molecule of Chinese medicine targeting PKM2

Peer-Reviewed Articles

1. Peng Yang, Zongwei Li, Hanqing Li, Yangxu Lu, Haili Wu, Zhuoyu Li^*. Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer. Cellular Signalling, 2015, 27, 1525-1532. IF: 4.315

2. Zongwei Li, Peng Yang, Zhuoyu Li^*. The multifaceted regulation and functions of PKM2 in tumor progression. Biochimica et Biophysica Acta-Reviews on cancer, 2014, 1846, 285-296. IF: 9.433

3. Peng Yang, Zongwei Li, Rong Fu, Haili Wu, Zhuoyu Li^*. Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling. Cellular Signalling, 2014, 26, 1853–1862. IF: 4.315

4. Peng Yang^#, Zongwei Li^#*, Lichao Zhang, Hanqing Li, Zhuoyu Li^*.  Analysis of metabonomic profiling alterations in a mouse model of colitis-associated cancer and 2-deoxy-D-glucose treatment. RSC Advances. 2016, 6, 58862. IF: 3.2

5. Peng Yang, Zongwei Li, Yingying Wang, Lichao Zhang, Haili Wu, Zhuoyu Li^*. Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells. Biochemical and Biophysical Research Communications, 2015, 459(2), 327-332. IF: 2.297

6. Peng Yang, Zhuoyu Li, Hanqing Li^*. Potential Roles of Protease Inhibitors in Cancer Progression. Asian Pacific Journal of Cancer Prevention, 2016, 16 (18), 8047-8052. IF: 2.514

7. Rong Fu^#, Peng Yang^#, Haili Wu, Zongwei Li, Zhuoyu Li^*. GRP78 secreted by colon cancer cells facilitates cell proliferation via PI3K/Akt signaling. Asian Pacific Journal of Cancer Prevention, 2014, 15 (17), 7245-7249. IF: 2.514

8. Haili Wu, Zongwei Li, Peng Yang, Lichao Zhang, Yongsheng Fan, Zhuou Li^*.  PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cells. Cellular Signalling, 2014, 26, 2397-2405. IF: 4.315

9. Yanan Peng, Zongwei Li, Peng Yang, Ian P. Newton, Hua Ren, Lichao Zhang, Haili Wu, Zhuoyu Li^*. Direct contacts with colon cancer cells regulate the differentiation of bone marrow mesenchymal stem cells into tumor associated fibroblasts. Biochemical and Biophysical Research Communications, 2014, 451, 68-73. IF: 2.297

10. Zongwei Li, Yingying Wang, Haili Wu, Lichao Zhang, Peng Yang, Zhuoyu Li. GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the β-catenin signaling. Oncotarget, 2014, 5(14): 5369-5380. IF: 6.359

Research Grants

1. The molecular mechanism of PKM2 regulating autophagy in colon cancer cells. Source: Shanxi Province Science Foundation for Youths (201601D021107), Period: 07/01/2016-12/31/2018.

2. The antitumor mechanism of tanshinone IIA intervening energy metabolism in colon cancer cells via PKM alternative splicing. Source: Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi (2016121), Period: 01/01/2016-12/31/2018.