Lichao Zhang   Ph.D
	Associate professor   Master Supervisor
	Email: zlc@sxu.edu.cn

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Education and work experience

Aug 2017-present     Institutes of Biomedical Sciences Shanxi University, Lecturer

Sep 2012-Jul 2017      Shanxi University, Ph.D

Sep 2008-Jul 2012      Shanxi University, Bioscience

Areas of interests

     My research investigates the molecular biological mechanisms of specific biomolecules (eg, glucose regulator protein 78, GRP78) on tumor progression, and design drug to target  these specific molecules. In addition, I extracte and selecte small molecule anti-tumor drugs from natural product. The current research focuses on:

1. The role of GRP78 in the process of interacting between tumor cells and tumor microenvironment

2. Screening and mechanism-researching of anti-tumor small molecules in natural products

Publications:

1、Lichao Zhang #, Xiaoqing Lu #, Yuanzhi Xu #, Xiaoqin La, Jinmiao Tian, Aiping Li, Hanqing Li, Changxin Wu, Yanfeng Xi, Guisheng Song, Zhaocai Zhou, Wenqi Bai*, Liwei An*, Zhuoyu Li*, Tumor-associated macrophages confer colorectal cancer 5-fluorouracil resistance by promoting MRP1 membrane translocation via an intercellular CXCL17/CXCL22-CCR4-ATF6-GRP78 axis, Cell Death & Disease. 2023 Sep 1;14(9):582.

2、Lichao Zhang*, Ya-ning Liu, Xiao-qin La, Shuai-tao Li, Li-na Wen, Ting Liu, Han-qing Li, Ai-ping Li, Haitao Wu, Chang-xin Wu, Zhuo-yu Li*, The bound polyphenols of foxtail millet (Setaria italica) inner shell inhibit breast cancer by promoting lipid accumulation-induced autophagic death, Food and Chemical Toxicology, 177 (2023) 113855.

3、Yuxuan An#, Xiaoqin La#, Songtao Li, Jinmiao Tian, Xiaxia Fan, Kaili Cui, Lichao Zhang*, Zhuoyu Li*. Polyphenols from whole millet grain(Setaria italica) alleviate glucose and lipid homeostasis in diet-induced-obese mice by increasing endogenous GLP-1, Journal of the Science of Food and Agriculture. 2023 Aug. DOI:10.1002/jsfa.12901.

4、Jinmiao Tian#, Lichao Zhang#*, Xiaoqin La, Xiaxia Fan, Aiping Li, Changxin Wu, Yuxuan An, Shuning Yan, Xiushan Dong, Haitao Wu, Zhuoyu Li*. Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism, Cellular Signalling. 2023 Aug:108:110719.

5、Xiaxia Fan#，Lichao Zhang#*，Xiaoqin La#，Jinmiao Tian，Ghani Israr，Aiping Li，Changxin Wu，Yuxuan An，Songtao Li，Xiushan Dong，Zhuoyu Li*，Salvianolic acid A attenuates inflammation-mediated atherosclerosis by suppressing GRP78 secretion of endothelial cells，Journal of Ethnopharmacology. 2023 May 23:308:116219.

6、Aiping Li，Wenbo Cui，Yirui Zhao，Tingting Luo，Qingyu Zhang，Yuetao Liu，Ke Li，Xuemei Qin*，Lichao Zhang*，Exploration of the main effective constituent and the mechanism in Astragali Radix in the treatment for doxorubicin-induced nephropathy by integrating metabolomics and molecular docking，Journal of Ethnopharmacology，305 (2023) 116074.

7、Kaili Cui#，Lichao Zhang#，Xiaoqin La，Haili Wu，Ruipeng Yang，Hanqing Li，Zhuoyu Li*, Ferulic Acid and P-Coumaric Acid Synergistically Attenuate Non-Alcoholic Fatty Liver Disease through HDAC1/PPARG-Mediated Free Fatty Acid Uptake, International Journal Of Molecular Sciences, 2022, 23(23), 15297.

8、Lichao Zhang，Yaning Liu，Xiaoqin La，Shuning Yan，Yu Chen，Jingyi Liang，Zhuoyu Li*，The potential mechanism of Neu5Gc inducing colorectal cancer based on network pharmacology and experimental validation，Naunyn-Schmiedeberg's Archives of Pharmacology， (2022). https://doi.org/10.1007/s00210-022-02345-w.

9、Lichao Zhang#, Xiaoqin La#, Jinmiao Tian, Hanqing Li, Aiping Li, Yizhi Liu, Changxin Wu, Zhuoyu Li*, The phytochemical vitexin and syringic acid derived from foxtail fillet bran inhibit breast cancer cells proliferation via GRP78/SREBP-1/SCD1 signaling axis, Journal of Functional Foods. 2021, 85, 104620.

10、 Xiaoqing Lu#, Rui Yang#, Lichao Zhang#, Yanfeng Xi, Jiping Zhao, Fusheng Wang, Huanhu Zhang, Zhuoyu Li*, Macrophage Colony-stimulating Factor Mediates the Recruitment of Macrophages in Triple negative Breast Cancer. International Journal of Biological Sciences. 2019; 15(13): 2859-2871.

11、Xiaoqin La#, Lichao Zhang#, Zhuoyu Li*, Hanqing Li, Yufei Yang.(-)-Epigallocatechin Gallate (EGCG) Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU by Inhibiting GRP78/NF-κB/miR-155-5p/MDR1 Pathway. J Agric Food Chem. 2019; 67 (9), 2510-2518.

12、Yufei Yang#, Lichao Zhang#, Xiaoqin La# , Zhuoyu Li*, Hanqing Li, Songjia Guo. Salvianolic acid A inhibits tumor-associated angiogenesis by blocking GRP78 secretion. Naunyn-Schmiedeberg's Archives of Pharmacology. 2019; 392 (4), 467-480.

13、Lichao Zhang, Zongwei Li, Guobin Ding, Xiaoqin La, Peng Yang, Zhuoyu Li*. GRP78 plays an integral role in tumor cell inflammation-related migration induced by M2 macrophages. Cellular Signalling. 2017；37：136-48.

14、Lichao Zhang, Zongwei Li, Tongli Shi, Xiaoqin La, Hanqing Li, Zhuoyu Li*. Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic for targeting cancer cells. BMC biotechnology. 2016; 16:1-13.

15、Lichao Zhang, Zongwei Li, Yongsheng Fan, Hanqing Li, Zhuoyu Li*, Yaoping Li. Overexpressed GRP78 affects EMT and cell-matrix adhesion via autocrine TGF-beta/Smad2/3 signaling. The international journal of biochemistry & cell biology. 2015; 64:202-11.

16、Zongwei Li#,Lichao Zhang#, Hanqin Li, Shuhua Shan, Zhuoyu Li*. Glucose regulated protein 78 promotes cell invasion via regulation of uPA production and secretion in colon cancer cells. BMB Reports. 2014; 47:445-50.

17、Zongwei Li, Lichao Zhang, Yarui Zhao, Hanqing Li, Hong Xiao, Rong Fu, et al. Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion. The international journal of biochemistry & cell biology. 2013; 45:987-94.

18、Zongwei Li, Ming Zhuang, Lichao Zhang, Xingnan Zheng, Peng Yang, Zhuoyu Li*. Acetylation modification regulates GRP78 secretion in colon cancer cells. Scientific reports. 2016; 6:30406.

19、Zongwei Li, Yingying Wang, Haili Wu, Lichao Zhang, Peng Yang. GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the β-catenin signaling. Oncotarget. 2014.

20、Zongwei Li, Yingying Wang, Ian P. Newton, Lichao Zhang, Penyu Ji, Zhuoyu Li*. GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKbeta. Cellular signalling. 2015; 27:1237-45.