Zhonghua Zhao   Ph.D
	Professor   Master Supervisor
	Email: zhzhao@sxu.edu.cn

EDUCATION

Ph.D. Institute of Genetics and Developmental Biology, CAS, China. 2010

M.S.  Institute of Biotechnology, Shanxi University, China. 2006

B.S.   Biology Sciences, Shanxi University, China. 2003

PROFESSIONAL EXPERIENCE

2016-present: Principle Investigator, Institutes of Biomedical Sciences, Shanxi University, Taiyuan, China.

214-2016: Senior Research Fellow, LKCmedicine School, Nanyang Technological University, Singapore.

2010-2014: Research Fellow, Institute of Molecular and Cellular Biology, A*STAR, Singapore.

RESEARCH INTEREST

Hedgehog Signalling pathway. The Hedgehog (Hh) Signalling pathway plays important roles in embryogenesis, organogenesis and homeostasis in adulthood in most of animals. Aberrant Hh activity causes development failure, deformation as well as many diseases. To understand the molecular mechanism of Hh pathway will help us to figure out the related disease pathology and identify new target sites as well as new drugs.

Projects

1. Mechanism of Hh signaling pathway

2. Cilium related signalling pathway and genetic diseases.

3. Molecular screening platform for Hh pathway

Collaboration projects

1. Genetic mechanism of TB susceptibility in vertebrate

2. Establishment of zebrafish model of human rare diseases

publications：

1. Zhonghua Zhao, Raymond Teck Ho Lee, Ganesh Pusapati, Audrey Iyu, Rajat Rohatgi, and Philip Ingham. (2015) An essential Role for Grk2 in Hedgehog signalling downstream of Smoothened. EMBO Reports, doi: 10.15252/embr.201541532. (IF: 9.055)

2. Raymond Tech Ho Lee^*, Zhonghua Zhao^* and Philip W. Ingham. (2015) Development at a glance: Hedgehog signaling. Development, 143(3): 367-372. (Co-first author, IF: 6.462)

3. Ashish K. Maurya^*, Jin Ben^*, Zhonghua Zhao^*, Raymond Lee, Weixin Niah, Ashley Shu Mei Ng, Stone Elworthy, Fredericus JM van Eeden and Philip W. Ingham. (2013) Modulation of Kif7 sub-cellular distribution by Hedgehog activity mediates the regulation of Gli transcription factor activity in the zebrafish. Plos Genetics, 9(12): p e1003955 (Co-first author, IF: 7.528)

4. Andreas van Impel, Zhonghua Zhao, Dorien M. A. Hermkens, M. Guy Roukens, Johanna C. Fischer, Josi Peterson-Maduro, Henricus Duckers, Elke A. Ober, Philip W. Ingham, and Stefan Schulte-Merker. (2014) Divergence of zebrafish and mouse lymphatic cell fate specification pathways. Development,141:1228-1238. (IF: 6.462)

5. Sigrid Nachtergaele, Daniel M. Whalen, Laurel K. Mydock, Zhonghua Zhao, Tomas Malinauskas, Kathiresan Krishnan, Philip W. Ingham, Douglas F. Covey and Christian Siebold. (2013) Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. Elife, 2: p.e01340. (IF: 9.322)

6. Xingang Wang^*, Zhonghua Zhao^*, Julius Muller, Audrey Iyu, Alexis Jiaying Khng, Ernesto Guccione, Yijun Ruan, and Philip W. Ingham. (2013) Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish. Biology open, 2 (11): 1203-1213. (Co-first author, IF: 2.416)

7. Lan Zhao^*, Jian Huang^*, Zhonghua Zhao^*, Qun Li, Yongbiao Xue. (2010) The Skp1-like protein SSK1 is required for cross-pollen compatibility in SRNase- based self-incompatibility. Plant Journal, 62(1):52-63. (Co-first author, IF: 5.972)

8. Guang Chen, Bin Zhang, Zhonghua Zhao, Zhenghua Sui, Hui Zhang and Yongbiao Xue. (2010) A life or death decision' for pollen tubes in S RNasebased self-incompatibility. Journal of Experimental Botany, 61(7):2027-37. (IF: 5.364)

9. Yijing Zhang, Zhonghua Zhao and Yongbiao Xue. (2009) Roles of proteolysis inplant self-incompatibility. Annual Review of Plant Biology, 60:21-42. (IF: 23.654)

10. Zhonghua Zhao, Qun Zeng and Shuqing Zhao. (2006) The Molecular Mechanism of Vernalization in Plants. Chinese Bulletin of botany, 23(1):60-66. (in Chinese)

11. Qun Zeng, Zhonghua Zhao and Shuqing Zhao. (2006) Signal Pathways of Flowering Time Regulation in Plant. Hereditas, 28 (8): 1031-1036. (in Chinese)