|
Changxin Wu Ph.D |
| Professor Doctoral Supervisor | |
| Email: cxw20@sxu.edu.cn |
Education
1983-1988: Bachelor Degree, Clinical Veterinary Medicine, Vet School Yangzhou University;
1988-1991: Master Degree, Preventive Veterinary Medicine, Vet School, Yangzhou University;
2002-2005: Doctor of Philosophy, Infection and Immunity, University of Cambridge
Research Experience
1991-1994: Teaching Assistant, Vet School, Yangzhou University,China
1994-1999: Lecturer, Vet School, Yangzhou University, China
1999-2000: Visiting Scholar, University of Cambridge, UK
2000-2001: Research Assistant, Department of Zoology, University of Cambridge, UK
2002-2005: Welcome Trust International Fellow, University of Cambridge, Institute of Animal Health, UK
2006-2009: Research Associate, Department of Medicine, School of Clinical Medicine, University of Cambridge, UK
2009-20012: Scientist, Department of Medicine, School of Clinical Medicine, University of Cambridge, UK
2012-2015: Senior Scientist, Department of Medicine, School of Clinical Medicine, University of Cambridge, Uk
2015- Professor of Infection and Immunity, Director of the Institutes of Biomedical Sciences, Shanxi University, China
My laboratories have long term interest in infection and immunity in humans and animals, such as mycobacterium tuberculosis, Mtb, in particular；We also interested in primary immunodeficiency in humans.
The mechanisms of susceptibility to infections in humans and domestic animals
My laboratories are investigating the mechanisms of susceptibility to infections in humans and domestic animals. We screen, identify and characterize genes in the host genome that carry sequence variants involved in resistance to infection and predispose to infectious diseases. Discovery of such genes can open new biological pathways and provide new targets for intervention. We use methods of genetics, including genome-wide association studies (GWAS) and the 1st , 2nd and 3rd generation sequencing, establish and apply in vitro and in vivo models of infections and techniques of molecular and cellular biology to understand underlying biological mechanisms protecting from infections.
Investigation into genetics of susceptibility to tuberculosis and elucidation of biological mechanisms involved host susceptibility to TB
We currently focus on susceptibility to tuberculosis (TB) and mycobacterial infection. Our groups consist of TB clinicians in hospitals, scientists in the national or local Center for Disease Control (CDC) and experts in human genetics and other mycobacterial research institutes in China. In collaboration with the labs of infectious disease division in Medicine Department, School of Clinical Medicine and Veterinary Science Center in the Department of Veterinary，Vet School, Cambridge University and related labs in other western universities or institutes, we perform functional analysises of the genes in cellular and animal models to elucidate the mechanisms of genetic variants affecting the susceptibility to TB at molecular and cellular levels after screening human genes associated with TB susceptibility using genetics approaches. These researches will reveal human genes that predispose to or protect from TB and may highlight new pathways that are involved in control of M. tuberculosis infection and progression to pulmonary TB. We will also combine information obtained in these experiments to investigate interaction between human genes that predispose to TB and virulence factors of mycobacteria during TB development. Eventually, our goals are to lead to better understanding of TB pathogenesis and may develop of new interventions and therapeutics to treat infections, and generate new strategies for TB effective prevention, control and therapy.
Genetic analyses of patients with rare diseases and primary Immunodeficiencies
Taking advantage of the highest incidence of rare diseases and very rich biomedical resources in Shanxi , China, we apply genetic approaches to screen genetic variants which are causative to rare diseases. My labs are particularly interested in Primary Immunodeficiencies (PIDs) comprise a heterogeneous group of genetic disorders that affect functions of the immune system and manifest as severe and/or recurrent infections. Mutations in more than human 200 genes are known to cause various PIDs. We study PID patients in collaboration with clinicians and clinical scientists working at hospitals in Shanxi Province and across China. We use whole exome sequencing to search for causative mutations, followed by detailed functional molecular analyses of the affected cellular pathways in vitro and in vivo models in the Institutes of Biomedical Sciences (IBMS), Shanxi University, China.
Collaborators
Dr Han Xiao (Lab of rare disease, IBMS)
Dr Zhonghua Zhao ( Lab of Zebrafish, IBMS )
Dr Qiuhong Xiong (Lab of Infection and immunity, IBMS）
Dr Ping Li (Lab of rare disease, IBMS )
Dr Qinglai Meng (Lab of Infectious Diseases, IBMS)
Professor Yaowu Zheng ( Center for Experimental Animal, IBMS)
Professor Jinpei Ye (Lab Stem Cell biology, IBMS)
Professor Cheng Chuanfu (Division of Animal Infectious Diseases, Shehezi University, China
Professor Nianshu Zhang （Department of Biochemistry, Cambridge)
Professor Ian McConnell (Center for Veterinary Medicine, Cambridge)
Professor Sergey Nejestev (TB Lab, Medical School, Cambridge)
Professor John Sinclair (Division of Infectious Diseases, Cambridge)
Professor Barbara Blacklaws (Division of Infection and Immunity, Cambridge)
Selected Publications
1. Liu, S.; Yang, B.; Hou, Y.; Cui, K.; Yang, X.; Li, X.; Chen, L.; Liu, S.; Zhang, Z.; Jia, Y.; Xie, Y.; Xue, Y.; Li, X.; Yan, B.; Wu, C.; Deng, W.; Qi, J.; Lu, D.; Gao, G. F.; Wang, P.; Shang, G., The mechanism of STING autoinhibition and activation. Mol Cell 2023, 83 (9), 1502-1518.e10.
2. Yang, B.; Jia, Y.; Meng, Y.; Xue, Y.; Liu, K.; Li, Y.; Liu, S.; Li, X.; Cui, K.; Shang, L.; Cheng, T.; Zhang, Z.; Hou, Y.; Yang, X.; Yan, H.; Duan, L.; Tong, Z.; Wu, C.; Liu, Z.; Gao, S.; Zhuo, S.; Huang, W.; Gao, G. F.; Qi, J.; Shang, G., SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry. Proc Natl Acad Sci U S A 2022, 119 (4).
3. Yaigoub, H.; Fath, N.; Tirichen, H.; Wu, C.; Li, R.; Li, Y., Bidirectional crosstalk between dysbiotic gut microbiota and systemic lupus erythematosus: What is new in therapeutic approaches? Clin Immunol 2022, 244, 109109.
4. Wen, D.; Cui, J.; Li, P.; Xiong, Q.; Chen, G.; Wu, C., Syndecan-4 assists Mycobacterium tuberculosis entry into lung epithelial cells by regulating the Cdc42, N-WASP, and Arp2/3 signaling pathways. Microbes Infect 2022, 24 (4), 104931.
5. Yang, C.; Ma, X.; Wu, J.; Han, J.; Zheng, Z.; Duan, H.; Liu, Q.; Wu, C.; Dong, Y.; Dong, L., Low serum calcium and phosphorus and their clinical performance in detecting COVID-19 patients. J Med Virol 2021, 93 (3), 1639-1651.
6. Li, J.; Li, Z.; Cui, X.; Wu, C., Bayesian phylodynamic inference on the temporal evolution and global transmission of SARS-CoV-2. J Infect 2020, 81 (2), 318-356.
7. Cuchet-Lourenço, D.; Eletto, D.; Wu, C.; Plagnol, V.; Papapietro, O.; Curtis, J.; Ceron-Gutierrez, L.; Bacon, C. M.; Hackett, S.; Alsaleem, B.; Maes, M.; Gaspar, M.; Alisaac, A.; Goss, E.; AlIdrissi, E.; Siegmund, D.; Wajant, H.; Kumararatne, D.; AlZahrani, M. S.; Arkwright, P. D.; Abinun, M.; Doffinger, R.; Nejentsev, S., Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation. Science 2018, 361 (6404), 810-813.
8. Curtis, J.; Luo, Y.; Zenner, H. L.; Cuchet-Lourenço, D.; Wu, C.; Lo, K.; Maes, M.; Alisaac, A.; Stebbings, E.; Liu, J. Z.; Kopanitsa, L.; Ignatyeva, O.; Balabanova, Y.; Nikolayevskyy, V.; Baessmann, I.; Thye, T.; Meyer, C. G.; Nürnberg, P.; Horstmann, R. D.; Drobniewski, F.; Plagnol, V.; Barrett, J. C.; Nejentsev, S., Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration. Nat Genet 2015, 47 (5), 523-527.
9. Yang, J.; Li, X.; Al-Lamki, R. S.; Wu, C.; Weiss, A.; Berk, J.; Schermuly, R. T.; Morrell, N. W., Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension. Arterioscler Thromb Vasc Biol 2013, 33 (1), 34-42.
10. Angulo, I.; Vadas, O.; Garçon, F.; Banham-Hall, E.; Plagnol, V.; Leahy, T. R.; Baxendale, H.; Coulter, T.; Curtis, J.; Wu, C.; Blake-Palmer, K.; Perisic, O.; Smyth, D.; Maes, M.; Fiddler, C.; Juss, J.; Cilliers, D.; Markelj, G.; Chandra, A.; Farmer, G.; Kielkowska, A.; Clark, J.; Kracker, S.; Debré, M.; Picard, C.; Pellier, I.; Jabado, N.; Morris, J. A.; Barcenas-Morales, G.; Fischer, A.; Stephens, L.; Hawkins, P.; Barrett, J. C.; Abinun, M.; Clatworthy, M.; Durandy, A.; Doffinger, R.; Chilvers, E. R.; Cant, A. J.; Kumararatne, D.; Okkenhaug, K.; Williams, R. L.; Condliffe, A.; Nejentsev, S., Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Science 2013, 342 (6160), 866-71.
11. Goodall, J. C#.; Wu, C#.; Zhang, Y.; McNeill, L.; Ellis, L.; Saudek, V.; Gaston, J. S., Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Proc Natl Acad Sci U S A 2010, 107 (41), 17698-703.
Publications
1. Zhang, L. C.; Liu, Y. N.; La, X. Q.; Li, S. T.; Wen, L. N.; Liu, T.; Li, H. Q.; Li, A. P.; Wu, H.; Wu, C. X.; Li, Z. Y., The bound polyphenols of foxtail millet (Setaria italica) inner shell inhibit breast cancer by promoting lipid accumulation-induced autophagic death. Food Chem Toxicol 2023, 177, 113855.
2. Xiong, Q.; Sun, H.; Xing, W.; Li, X.; Chen, G.; Zhao, Z.; Wu, C.; Li, P., WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism. Free Radic Biol Med 2023, 201, 89-97.
3. Wang, P. H.; Nawal Bahoussi, A.; Tariq Shah, P.; Guo, Y. Y.; Wu, C.; Xing, L., Genetic comparison of transmissible gastroenteritis coronaviruses. Front Vet Sci 2023, 10, 1146648.
4. Tufail, M.; Wu, C., Wnt3a is a promising target in colorectal cancer. Med Oncol 2023, 40 (3), 86.
5. Tufail, M.; Wu, C., SRPKs: a promising therapeutic target in cancer. Clin Exp Med 2023.
6. Tufail, M.; Wu, C., Exploring the Burden of Cancer in Pakistan: An Analysis of 2019 Data. J Epidemiol Glob Health 2023.
7. Tian, J.; Zhang, L.; La, X.; Fan, X.; Li, A.; Wu, C.; An, Y.; Yan, S.; Dong, X.; Wu, H.; Li, Z., Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism. Cell Signal 2023, 108, 110719.
8. Shah, P. T.; Wang, J.; Liu, Y.; Hussain, B.; Ma, Z. H.; Wu, C.; Xing, L., The phylogenetic and phylogeographic landscape of the beak and feather disease virus, 1996-2022. Infect Genet Evol 2023, 112, 105442.
9. Shah, P. T.; Bahoussi, A. N.; Yang, C.; Yao, G.; Dong, L.; Wu, C.; Xing, L., Genetic Characteristics and Phylogeographic Dynamics of Lagoviruses, 1988-2021. Viruses 2023, 15 (4).
10. Shah, P. T.; Bahoussi, A. N.; Cui, X.; Shabir, S.; Wu, C.; Xing, L., Genetic diversity, distribution, and evolution of chicken anemia virus: A comparative genomic and phylogenetic analysis. Front Microbiol 2023, 14, 1145225.
11. Ma, Z. H.; Nawal Bahoussi, A.; Tariq Shah, P.; Guo, Y. Y.; Dong, L.; Wu, C.; Xing, L., Phylogeographic dynamics and molecular characteristics of Enterovirus 71 in China. Front Microbiol 2023, 14, 1182382.
12. Liu, Y.; Zhu, D.; Liu, J.; Sun, X.; Gao, F.; Duan, H.; Dong, L.; Wang, X.; Wu, C., Pediococcus pentosaceus PR-1 modulates high-fat-died-induced alterations in gut microbiota, inflammation, and lipid metabolism in zebrafish. Front Nutr 2023, 10, 1087703.
13. Liu, S.; Yang, B.; Hou, Y.; Cui, K.; Yang, X.; Li, X.; Chen, L.; Liu, S.; Zhang, Z.; Jia, Y.; Xie, Y.; Xue, Y.; Li, X.; Yan, B.; Wu, C.; Deng, W.; Qi, J.; Lu, D.; Gao, G. F.; Wang, P.; Shang, G., The mechanism of STING autoinhibition and activation. Mol Cell 2023, 83 (9), 1502-1518.e10.
14. Han, J.; Cui, X.; Yuan, T.; Yang, Z.; Liu, Y.; Ren, Y.; Wu, C.; Bian, Y., Plasma-derived exosomal let-7c-5p, miR-335-3p, and miR-652-3p as potential diagnostic biomarkers for stable coronary artery disease. Front Physiol 2023, 14, 1161612.
15. Feng, J.; Li, F.; Sun, L.; Dong, L.; Gao, L.; Wang, H.; Yan, L.; Wu, C., Characterization and genome analysis of phage vB_KpnS_SXFY507 against Klebsiella pneumoniae and efficacy assessment in Galleria mellonella larvae. Front Microbiol 2023, 14, 1081715.
16. Fan, X.; Zhang, L.; La, X.; Tian, J.; Israr, G.; Li, A.; Wu, C.; An, Y.; Li, S.; Dong, X.; Li, Z., Salvianolic acid A attenuates inflammation-mediated atherosclerosis by suppressing GRP78 secretion of endothelial cells. J Ethnopharmacol 2023, 308, 116219.
17. Bahoussi, A. N.; Shah, P. T.; Zhao, J. Q.; Wang, P. H.; Guo, Y. Y.; Wu, C.; Xing, L., Multiple potential recombination events among Newcastle disease virus genomes in China between 1946 and 2020. Front Vet Sci 2023, 10, 1136855.
18. Bahoussi, A. N.; Shah, P. T.; Guo, Y. Y.; Liu, Y.; Wu, C.; Xing, L., Evolutionary adaptation of bovine coronavirus (BCoV): Screening of natural recombinations across the complete genomes. J Basic Microbiol 2023, 63 (5), 519-529.
19. Zhang, Y.; Wang, X.; Li, Z.; Zhang, J.; Wang, Y.; Wu, C.; Chen, C.; Li, J.; Zhang, H., Brucella melitensis outer membrane protein 25 interacts with ferritin heavy polypeptide 1 in human trophoblast cells. Mol Med Rep 2022, 26 (1).
20. Zhang, H.; Huang, Z.; Lv, L.; Xin, Y.; Wang, Q.; Li, F.; Dong, L.; Wu, C.; Ingham, P. W.; Zhao, Z., A transgenic zebrafish for in vivo visualization of cilia. Open Biol 2022, 12 (8), 220104.
21. Yao, X.; Zhang, Z.; Mei, Q.; Li, S.; Xing, L.; Long, Y.; Zhang, D.; Wang, J.; Wang, X.; Xie, B.; Yang, B.; Gao, Y.; Wu, C.; Meng, Q., A highly sensitive bead-based flow cytometric competitive binding assay to detect SARS-CoV-2 neutralizing antibody activity. Front Immunol 2022, 13, 1041860.
22. Yang, B.; Jia, Y.; Meng, Y.; Xue, Y.; Liu, K.; Li, Y.; Liu, S.; Li, X.; Cui, K.; Shang, L.; Cheng, T.; Zhang, Z.; Hou, Y.; Yang, X.; Yan, H.; Duan, L.; Tong, Z.; Wu, C.; Liu, Z.; Gao, S.; Zhuo, S.; Huang, W.; Gao, G. F.; Qi, J.; Shang, G., SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry. Proc Natl Acad Sci U S A 2022, 119 (4).
23. Yaigoub, H.; Tirichen, H.; Xin, X.; Shi, S.; Wu, C.; Li, R.; Li, Y., Isolation of Viable Single Cells With High Yield and Purity Using a Small Amount of Human Kidney Tissue Biopsy. Front Cell Dev Biol 2022, 10, 822275.
24. Yaigoub, H.; Fath, N.; Tirichen, H.; Wu, C.; Li, R.; Li, Y., Bidirectional crosstalk between dysbiotic gut microbiota and systemic lupus erythematosus: What is new in therapeutic approaches? Clin Immunol 2022, 244, 109109.
25. Wen, D.; Cui, J.; Li, P.; Xiong, Q.; Chen, G.; Wu, C., Syndecan-4 assists Mycobacterium tuberculosis entry into lung epithelial cells by regulating the Cdc42, N-WASP, and Arp2/3 signaling pathways. Microbes Infect 2022, 24 (4), 104931.
26. Wang, L.; Li, J.; Xiong, Q.; Zhou, Y. A.; Li, P.; Wu, C., Case Report: A Missense Mutation in Dyskeratosis Congenita 1 Leads to a Benign Form of Dyskeratosis Congenita Syndrome With the Mucocutaneous Triad. Front Pediatr 2022, 10, 834268.
27. Tufail, M.; Wu, C., Targeting the IGF-1R in prostate and colorectal cancer: reasons behind trial failure and future directions. Ther Deliv 2022, 13 (3), 167-186.
28. Tufail, M.; Wu, C., Psychological impact of COVID-19 pandemic on Parkinson's disease patients. Heliyon 2022, 8 (6), e09604.
29. Tufail, M.; Wu, C., RANK pathway in cancer: underlying resistance and therapeutic approaches. J Chemother 2022, 1-14.
30. Tufail, M.; Cui, J.; Wu, C., Breast cancer: molecular mechanisms of underlying resistance and therapeutic approaches. Am J Cancer Res 2022, 12 (7), 2920-2949.
31. Shah, P. T.; Tufail, M.; Wu, C.; Xing, L., THP-1 cell line model for tuberculosis: A platform for in vitro macrophage manipulation. Tuberculosis (Edinb) 2022, 136, 102243.
32. Ma, Y.; Sun, W.; Zhao, L.; Yao, M.; Wu, C.; Su, P.; Yang, L.; Wang, G., Generation of an mESC model with a human hemophilia B nonsense mutation via CRISPR/Cas9 technology. Stem Cell Res Ther 2022, 13 (1), 353.
33. Liu, Y.; Sun, X.; Zhang, J.; Gao, F.; Yu, L.; Dong, L.; Zhang, G.; Wu, C., Isolation and characterisation of Pulsatilla Radix-utilising bacteria Pediococcus pentosaceus PR-1 from human faeces. FEMS Microbiol Lett 2022, 369 (1).
34. Liu, Y.; Bahoussi, A. N.; Wang, P. H.; Wu, C.; Xing, L., Complete genome sequences of classical swine fever virus: Phylogenetic and evolutionary analyses. Front Microbiol 2022, 13, 1021734.
35. Li, P.; Wu, Y.; Wu, H.; Xiong, Q.; Zhao, N.; Chen, G.; Wu, C.; Xiao, H., Functional Characterization of FH Mutation c.557G>A Underlies Uterine Leiomyomas. Int J Mol Sci 2022, 23 (3).
36. Li, P.; Lan, W.; Li, J.; Zhang, Y.; Xiong, Q.; Ye, J.; Wu, C.; Xiao, H., Identification and Functional Evaluation of a Novel TBX4 Mutation Underlies Small Patella Syndrome. Int J Mol Sci 2022, 23 (4).
37. Li, J.; Gao, Z.; Chen, J.; Cheng, R.; Niu, J.; Zhang, J.; Yang, Y.; Yuan, X.; Xia, J.; Mao, G.; Liu, H.; Dong, Y.; Wu, C., Development of a panel of three multiplex allele-specific qRT-PCR assays for quick differentiation of recombinant variants and Omicron subvariants of SARS-CoV-2. Front Cell Infect Microbiol 2022, 12, 953027.
38. Hussain, B.; Xie, Y.; Jabeen, U.; Lu, D.; Yang, B.; Wu, C.; Shang, G., Activation of STING Based on Its Structural Features. Front Immunol 2022, 13, 808607.
39. Cui, X.; Yuan, T.; Ning, P.; Han, J.; Liu, Y.; Feng, J.; Lian, F.; Hao, M.; Dong, L.; Hao, J.; Xing, L.; Wu, C., Polymorphisms in the ASAP1 and SP110 Genes and Its Association with the Susceptibility to Pulmonary Tuberculosis in a Mongolian Population. J Immunol Res 2022, 2022, 2713869.
40. Cheng, T. Y.; Liu, Y. J.; Yan, H.; Xi, Y. B.; Duan, L. Q.; Wang, Y.; Zhang, T. T.; Gu, Y. M.; Wang, X. D.; Wu, C. X.; Gao, S., Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of Tumor Cells via ERK1/2. Cells 2022, 11 (24).
41. Bahoussi, A. N.; Wang, P. H.; Shah, P. T.; Bu, H.; Wu, C.; Xing, L., Evolutionary plasticity of zoonotic porcine Deltacoronavirus (PDCoV): genetic characteristics and geographic distribution. BMC Vet Res 2022, 18 (1), 444.
42. Bahoussi, A. N.; Wang, P. H.; Ma, Z. H.; Rani, N.; Wu, C.; Xing, L., Identification of novel recombinants and proposed standard reference genomes for phylogenetic classification of canine parvovirus-2 (CPV-2): Comprehensive analysis revealing global evolutionary trait. Front Vet Sci 2022, 9, 1030522.
43. Bahoussi, A. N.; Wang, P. H.; Guo, Y. Y.; Rabbani, N.; Wu, C.; Xing, L., Global Distribution and Natural Recombination of Hepatitis D Virus: Implication of Kyrgyzstan Emerging HDVs in the Clinical Outcomes. Viruses 2022, 14 (7).
44. Bahoussi, A. N.; Guo, Y. Y.; Wang, P. H.; Dahdouh, A.; Wu, C.; Xing, L., Genomic characteristics and recombination patterns of swine hepatitis E virus in China. Transbound Emerg Dis 2022, 69 (5), e3273-e3281.
45. Bahoussi, A. N.; Guo, Y. Y.; Shi, R. Z.; Wang, P. H.; Li, Y. Q.; Wu, C. X.; Xing, L., Genetic Characteristics of Porcine Hemagglutinating Encephalomyelitis Coronavirus: Identification of Naturally Occurring Mutations Between 1970 and 2015. Front Microbiol 2022, 13, 860851.
46. Zhao, N.; Yang, Y.; Li, P.; Xiong, Q.; Xiao, H.; Wu, C., Identification of Two Novel Compound Heterozygous EIF2AK3 Mutations Underlying Wolcott-Rallison Syndrome in a Chinese Family. Front Pediatr 2021, 9, 679646.
47. Zhao, N.; Wu, H.; Li, P.; Wang, Y.; Dong, L.; Xiao, H.; Wu, C., A novel pathogenic splice site variation in STK11 gene results in Peutz-Jeghers syndrome. Mol Genet Genomic Med 2021, 9 (8), e1729.
48. Zhang, Y.; Xiao, H.; Xiong, Q.; Wu, C.; Li, P., Two Novel Hydroxymethylbilane Synthase Splicing Mutations Predispose to Acute Intermittent Porphyria. Int J Mol Sci 2021, 22 (20).
49. Zhang, S. S.; Dong, L.; Wang, G. M.; Tian, Y.; Ye, X. F.; Zhao, Y.; Liu, Z. Y.; Zhai, J. Y.; Zhao, Z. L.; Wang, J. H.; Zhang, H. M.; Li, X. L.; Wu, C. X.; Yang, C. T.; Yang, L. J.; Du, H. X.; Wang, H.; Ge, Q. G.; Xiu, D. R.; Shen, N., Progressive liver injury and increased mortality risk in COVID-19 patients: A retrospective cohort study in China. World J Gastroenterol 2021, 27 (9), 835-853.
50. Yao, M.; Su, P.; Li, Z.; Cui, X.; Yang, Q.; Xing, X.; Lei, Y.; Lian, M.; Ren, T.; Wang, X.; Zheng, Y.; Wu, C., Knockout of Dip2c in murine ES cell line IBMSe001-B-1 by CRISPR/Cas9 genome editing technology. Stem Cell Res 2021, 53, 102236.
51. Yang, C.; Ma, X.; Wu, J.; Han, J.; Zheng, Z.; Duan, H.; Liu, Q.; Wu, C.; Dong, Y.; Dong, L., Low serum calcium and phosphorus and their clinical performance in detecting COVID-19 patients. J Med Virol 2021, 93 (3), 1639-1651.
52. Xiong, Q.; Song, N.; Li, P.; Fischer, S.; Konertz, R.; Wagle, P.; Glöckner, G.; Wu, C.; Eichinger, L., RNA(seq) and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16. BMC Genomics 2021, 22 (1), 444.
53. Xiong, Q.; Song, N.; Li, P.; Fischer, S.; Konertz, R.; Wagle, P.; Glöckner, G.; Wu, C.; Eichinger, L., Correction to: RNA(seq) and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16. BMC Genomics 2021, 22 (1), 555.
54. Xiong, Q.; Li, X.; Li, W.; Chen, G.; Xiao, H.; Li, P.; Wu, C., WDR45 Mutation Impairs the Autophagic Degradation of Transferrin Receptor and Promotes Ferroptosis. Front Mol Biosci 2021, 8, 645831.
55. Wang, L.; Xiong, Q.; Li, P.; Chen, G.; Tariq, N.; Wu, C., The negative charge of the 343 site is essential for maintaining physiological functions of CXCR4. BMC Mol Cell Biol 2021, 22 (1), 8.
56. Tirichen, H.; Yaigoub, H.; Xu, W.; Wu, C.; Li, R.; Li, Y., Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress. Front Physiol 2021, 12, 627837.
57. Meng, Q.; Wang, Y.; Long, Y.; Yue, A.; Mecklenburg, M.; Tian, S.; Fu, Y.; Yao, X.; Liu, J.; Song, D.; Wu, C.; Xie, B., Rapid Detection of Multiple Classes of β-Lactam Antibiotics in Blood Using an NDM-1 Biosensing Assay. Antibiotics (Basel) 2021, 10 (9).
58. Meng, Q.; Liu, S.; Meng, J.; Feng, J.; Mecklenburg, M.; Zhu, L.; Zhou, L.; Bülow, L.; Liu, J.; Song, D.; Wu, C.; Xie, B., Rapid personalized AMR diagnostics using two-dimensional antibiotic resistance profiling strategy employing a thermometric NDM-1 biosensor. Biosens Bioelectron 2021, 193, 113526.
59. Meng, Q.; Fu, Y.; Li, S.; Yan, Y.; Duan, D.; Anthony, D. D.; Zhu, Y.; Wu, X.; Qian, F.; Wu, C., Rapid, sensitive and cost-effective determination of immune checkpoint inhibitor activity using a magnetic bead-based binding assay. J Immunol Methods 2021, 498, 113134.
60. Liu, Y.; Wang, J.; Wu, C., Microbiota and Tuberculosis: A Potential Role of Probiotics, and Postbiotics. Front Nutr 2021, 8, 626254.
61. Liu, Y.; Wang, J.; Wu, C., Modulation of Gut Microbiota and Immune System by Probiotics, Pre-biotics, and Post-biotics. Front Nutr 2021, 8, 634897.
62. Han, J.; Ning, P.; Ge, A.; Ma, X.; Burton, J. A.; Yang, C.; Cui, X.; Wu, C.; Hao, J.; Dong, L., Corrigendum to "Association of polymorphisms of innate immunity-related genes and tuberculosis susceptibility in Mongolian population" [Hum. Immunol. 82(4) (2021) 232-239]. Hum Immunol 2021, 82 (9), 712.
63. Han, J.; Ning, P.; Ge, A.; Ma, X.; Alexander Burton, J.; Yang, C.; Cui, X.; Wu, C.; Hao, J.; Dong, L., Association of polymorphisms of innate immunity-related genes and tuberculosis susceptibility in Mongolian population. Hum Immunol 2021, 82 (4), 232-239.
64. Feng, J.; Gao, L.; Li, L.; Zhang, Z.; Wu, C.; Li, F.; Tong, Y., Characterization and genome analysis of novel Klebsiella phage BUCT556A with lytic activity against carbapenemase-producing Klebsiella pneumoniae. Virus Res 2021, 303, 198506.
65. Cui, J.; Chen, G.; Zhao, Z.; Wang, L.; Wen, D.; Xing, L.; Wu, C., ASAP1 regulates the uptake of Mycobacterium tuberculosis H37Ra in THP1-derived macrophages by remodeling actin cytoskeleton. Tuberculosis (Edinb) 2021, 129, 102090.
66. Chen, G.; Yang, Z.; Wen, D.; Guo, J.; Xiong, Q.; Li, P.; Zhao, L.; Wang, J.; Wu, C.; Dong, L., Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis. Immun Inflamm Dis 2021, 9 (3), 959-970.
67. Zhao, N.; Wang, J.; Xiao, H.; Wu, C., [Clinical and genetic characteristics of Chinese patients with Waardenburg syndrome]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020, 37 (10), 1186-1190.
68. Yao, M.; Yang, Q.; Lian, M.; Su, P.; Cui, X.; Ren, T.; Wang, X.; Wu, C.; Zheng, Y., Generation of Dip2a homozygous knockout murine ES cell line IBMSe001-A-1 via CRISPR/Cas9 technology. Stem Cell Res 2020, 45, 101778.
69. Wang, M.; Li, P.; Wang, H.; Dong, L.; Wu, C.; Zhao, Z., Identification and spatiotemporal expression of gpr161 genes in zebrafish. Gene 2020, 730, 144303.
70. Li, J.; Li, Z.; Cui, X.; Wu, C., Bayesian phylodynamic inference on the temporal evolution and global transmission of SARS-CoV-2. J Infect 2020, 81 (2), 318-356.
71. Cui, X.; Zhang, S.; Zhang, Q.; Guo, X.; Wu, C.; Yao, M.; Sun, D., Comprehensive MicroRNA Expression Profile of the Mammary Gland in Lactating Dairy Cows With Extremely Different Milk Protein and Fat Percentages. Front Genet 2020, 11, 548268.
72. Cui, J.; Chen, G.; Wen, D.; Wang, Y.; Zhao, Z.; Wu, C., Asap1 Affects the Susceptibility of Zebrafish to Mycobacterium by Regulating Macrophage Migration. Front Cell Infect Microbiol 2020, 10, 519503.
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74. Xiong, Q.; Li, W.; Li, P.; Zhao, Z.; Wu, C.; Xiao, H., Functional evidence for a de novo mutation in WDR45 leading to BPAN in a Chinese girl. Mol Genet Genomic Med 2019, 7 (9), e858.
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