Guangxin Chen Ph.D
	Lecturer Master Supervisor
	Email: chengx@sxu.edu.cn

Education and work experience

 Jul 2018 – present.  Institutes of Biomedical Science Shanxi University, Lecturer

Sep 2015 – Jun 2018.  Jilin University, Ph.D

Sep 2012 – Jun 2015.  Guangdong Ocean University, Master

Sep 2008 – Jun 2012.  HeBei North University, Bachelor

Areas of interests

My research investigates the effects of GPR109A on intestinal barrier permeability and intestinal inflammation, and explores the relationship between GPR109A and intestinal microbiota. In addition, I screen the chinese medicine monomer which inhibit the neuroinflammation.

Current interests on

Investigation the mechanism of susceptibility to human major diseases. Investigation the biological mechanisms involved host susceptibility to TB.

Publications:

1. Guangxin Chen, Xin Ran, Bai Li, Yuhang Li, Dewei He, Bingxu Huang, Shoupeng Fu, Juxiong Liu, Wei Wang. Sodium Butyrate Inhibits Inflammation andMaintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model. EBioMedicine, 2018, 30.

2. Guangxin Chen, Bingxu Huang, Shoupeng Fu, Bai Li, Xin Ran, Dewei He, Liqiang Jiang, Yuhang Li, Liwei Xie, Juxiong Liu and Wei Wang. G Protein-Coupled Receptor 1 109A and Host Microbiota Modulate Intestinal Epithelial Integrity during Sepsis. Frontiers in Immunology

3. Guangxin Chen, Shoupeng Fu, Wenqian Feng, Bingxu Huang, Shiyao Xu, Wei Wang and Juxiong Liu. AMP010014A09 in Sus Scrofa Encodes an Analog of G Protein-Coupled Receptor 109A, Which Mediates the Anti-Inflammatory Effects of Beta-Hydroxybutyric Acid. Cellular physiology and biochemistry, 2017, 42, 1420-1430.

4. Guangxin Chen, Juxiong Liu, Liqiang Jiang, Xin Ran, Dewei He, Yuhang Li, Bingxu Huang, Wei Wang, Shoupeng Fu. Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson's disease in Rats. International journal of molecular sciences 2017, 19, (1).

5. Guangxin Chen, Juxiong Liu, Bingxu Huang, Xin Ran, Liqiang Jiang, Yuhang Li, Wei Wang, Shoupeng Fu. Peiminine protects dopaminergic neurons frominflammation-induced celldeath by inhibitingthe ERK1/2 and NF-κB signalling pathways. International Journal of Molecular Sciences 2018, 19(3).

6. Guangxin Chen, Zhenhua Gao, Wenhui Chu, Zan Cao, Chunyi Li, Haiping ZhaoZhao. Effects of Chromium Picolinateon Fat Deposition, Activity and Genetic Expression of Lipid Metabolism-Related Enzymes in 21 Day Old Ross Broilers. Asian-Australasian Journal of Animal Science.2017.

7. Wenqian Feng^#, Yancheng Wu^#, Guangxin Chen^#, Shoupeng Fu, Bai Li, BingxuHuang, Dali Wang, Wei Wang and Juxiong Liu. Sodium Butyrate Attenuates Diarrhea in Weaned Piglets and Promotes Tight Junction Protein Expression in Colon in a GPR109A-Dependent Manner.  Cellular physiology and biochemistry, 2018; 47:1617-1629. Co-first author

8. Xin Ran^#, Yuhang Li^#, Guangxin Chen^#, Shoupeng Fu, Dewei He, Bingxu Huang, Libin Wei, Yuanqing Lin, Yingcheng Guo and Guiqiu Hu. Farrerol Ameliorates TNBS-Induced Colonic Inflammation by Inhibiting ERK1/2, JNK1/2, and NF-κB Signaling Pathway. International Journal of Molecular Sciences 2018, 19(7). Co-first author

9. Bingxu Huang, Dewei He, Guangxin Chen, Xin Ran, Wenjin Guo, Xingchi Kan, Wei Wang, Dianfeng Liu, Shoupeng Fu and Juxiong Liu. α-Cyperone inhibits LPS-induced inflammation in BV-2 cells through activation of Akt/Nrf2/HO-1 and suppression of the NF-κB pathway. Food & Function, 2018, 9(5).

10. Bingxu Huang, Juxiong Liu, Dongxu Ma, Guangxin Chen, Wei Wang, Shoupeng Fu. Myricetin prevents dopaminergic neurons from undergoing neuroinflammation-mediated degeneration in a lipopolysaccharide-induced Parkinson's disease model. Journal of Functional Foods, 2018, 45, 452-461.

11. Bingxu Huang, Juxiong Liu, Chen Ju, Dongxue Yang, Guangxin Chen, Shiyao Xu, Yalong Zeng, Xuan Yan, WeiWang, Dianfeng Liu and Shoupeng Fu. Licochalcone A Prevents the Loss of Dopaminergic Neurons by Inhibiting Microglial Activation in Lipopolysaccharide (LPS)-Induced Parkinson’s Disease Models. International Journal of Molecular Sciences 2017, 18(10).

12. Xuan Yan, Dianfeng Liu, Xiangyang Zhang, Dong Liu, Shiyao Xu , Guangxin Chen, Bingxu Huang, Wenzhi Ren, Wei Wang, Shoupeng Fu and Juxiong Liu. Vanillin Protects Dopaminergic Neurons against Inflammation-Mediated Cell Death by Inhibiting ERK1/2, P38 and the NF-κB Signaling Pathway. International Journal of Molecular Sciences 2017, 18(2).

13. Dewei He, Bingxu Huang, Shoupeng Fu, Yuhang Li, Xin Ran, Yandan Liu, Guangxin Chen, Juxiong Liu and Dianfeng Liu. Tubeimoside I Protects Dopaminergic Neurons Against Inflammation-Mediated Damage in Lipopolysaccharide (LPS)-Evoked Model of Parkinson's Disease in Rats. International Journal of Molecular Sciences, 2018, 19(8).

14. Jianhua Sun, Juxiong Liu, Bingxu Huang, Xingchi Kan, Guangxin Chen, Wei Wang and Shoupeng Fu. Kisspeptin-10 Induces-Casein Synthesis via GPR54 and Its Downstream Signaling Pathways in Bovine Mammary Epithelial Cells. International Journal of Molecular Sciences 2017, 18(12).