Mingze Yao
	Professor   Master Supervisor
	Email: yaomz@sxu.edu.cn

Education and Work Experience

  Dr. Mingze Yao received his B. Sc. in School of Life Sciences, Shanxi University, China in 2008. He then went to Institute of Biotechnology, Shanxi University as a Ph.D. student where he obtained his Ph. D. in Biochemistry and Molecular Biology in 2013. From 2014 to 2018, as an assistant professor and associate professor, he worked in the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine. Over the past five years，Dr. Yao devoted himself to the mechanisms of pluripotent maintenance and differentiation of embryonic stem cells and as first or co-author published 10 papers in the international journals including “Nature Communications”, “Cell Stem Cell”, “Nucleic Acids Research”, “Journal of Biological Chemistry” and “Scientific Reports”.

Research Interests:

1. The epigenetic mechanisms of cell fate determination

2. Using stem cell to study and treat human disease 　

Research Grants:

Principal Investigator:

1. Source: National Natural Science Foundation of China (31601050), Amount: ￥ 210,000.

2. The Pearl River S&T Nova Program of Guangzhou, Amount: ￥ 300,000.

3. Source: Guangdong Natural Science Funds (2015A030310041), Amount: ￥ 100，000. (Completed)

Key member:

1. Source: National Science and Technology Major Projects for “New Drugs Innovation and Development” (2018ZX09201002-005), Amount: ￥ 855,000.

2. Source: The Ministry of Science and Technology of the People’s Republic of China (2016YFA0100300), Amount: ￥ 930,000.

Publications:

1. Yao M, Zhou X, Zhou J, Gong S, Hu G, Li J, Huang K, Lai P, Shi G, Sun H, Wang H, Yao H, PCGF5 is required for neural differentiation of embryonic stem cells., Nature Communications, 2018, 9:1463. （IF: 12.353）

2. Peng X, So K, He L, Zhao Y, Zhou J, Li Y, Yao M, Xu B, Zhang S, Yao H, Hu P, Sun H, Wang H, MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation., Nucleic Acids Res (15), 2017, 8785-8805. （IF: 11.561）

3. Li H (#), Lai P (#), Jia Ji (#), Song Y, Xia Q, Huang K, He N, Ping W, Chen J, Yang Z, Li J, Yao M, Dong X, Zhao J, Hou C, Esteban M, Gao S, Pei D, Hutchins A, Yao H, RNA Helicase DDX5 inhibits reprogramming to pluripotency by miRNA-based repression of RYBP and its PRC1-dependent and -independent functions., Cell Stem Cell (20), 2017, 462-477. (#: co-first author) （IF: 23.290）

4. Wang X, Yao M, Yang B, Fu Y, Hu F, Liang A, Enzymology and thermal stability of phytase appA., RSC Advances, 2015, 54 (5):43863-43872. （IF: 2.936）

5. Huang K (#), Zhang X (#), Shi J (#), Yao M, Lin J, Li J, Liu H, Li H, Shi G, Wang Z, Zhang B，Chen J，Pan G，Jiang C，Pei D，Yao H，Dynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells., Scientific Reports, 2015, 5:17691. (#: co-first author) （IF: 4.122）

6. Liu L (#), Xu Y (#), He M, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C, Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins A, Wang D, Tse H, Schambach A, Frampton J, Qin B, Bao X, Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban M，Transcriptional pause release is a rate-limiting step for somatic cell reprogramming., Cell Stem Cell, 2014, 15 (5):574-588. (#: co-first author) （IF: 23.290）

7. Yao M, Lu W, Chen T, Wang W, Fu Y, Yang B, Liang A, Effect of metals ions on thermostable alkaline phytase from Bacillus subtilis YCJS isolated from soybean rhizosphere soil., Annals of Microbiology, 2014, 64 (3):1123-1131. （IF: 1.407）

8. Yao M, Wang X, Wang W, Fu Y, Liang A, Improving the thermostability of Escherichia coli phytase，appA，by enhancement of glycosylation., Biotechnology Letters, 2013, 35 (10):1669-1676. （IF: 1.846）

9. Huang K (#), Jia J (#), Wu C, Li M, Yao M, Jin J, Jiang C, Cai Y, Pei D, Pan G, Yao H, Ribosomal RNA gene transcription mediated by the master genome regulator protein CCCTC-binding factor (CTCF) is negatively regulated by the condensin complex., Journal of Biological Chemistry, 2013, 288 (36):26067-26077. (#: co-first author) （IF: 4.010）

10. Yao M, Zhang Y, Lu W, Hu M, Wang W, Liang A, Phytases: crystal structures, protein engineering and potential biotechnological applications., Journal of Applied Microbiology, 2012, 112 (1):1-14. （IF: 2.160）

Patent:

Liang A, Yao M, Wang W, Chai B, Fu Y, Zhang Z, Shen Q，A highly heat-resistant phytase producing yeast strain and its construction method, China patent 201310125275.3.