Xiaoqin La  Ph.D
	Lecturer  Master Supervisor
	Email：laxiaoqin@sxu.edu.cn

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Education and work experience:

2010.09-2014.07 Bachelor degree, College of Life Science, Shanxi Normal University

2014.09-2019.07 Ph.D., biochemistry and molecular Biology, Institute of Biotechnology, Shanxi University

2019.07-2021.02, Lecturer, School of Life Science, Shanxi University

2021.03-now, Lecturer, Institute of Biomedical Sciences, Shanxi University

Major Research Direction:

Mainly engaged in the research of cell signal transduction and molecular nutritional intervention. Relevant research results have been published in the Journal of Agricultural and Food Chemistry, Journal of Functional Foods, Cellular Signalling and so on. Current research focuses on the following three aspects:

1. The role of Glucose regulated protein 78 (GRP78) in tumor cells and tumor microenvironment

2. Study on the extraction of functional molecules from natural products and the anti-tumor molecular mechanism

3. Identification of nutritional components in natural products and the intervention on gastrointestinal diseases

Major Enrollment:

1. Academic master: Biochemistry and molecular biology, genetics

2. Professional master: Food processing and safety

Representative academic papers:

1. Xiaoqin La, Lichao Zhang, Zhuoyu Li, et al. (-)-Epigallocatechin Gallate (EGCG) Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU by Inhibiting GRP78/NF-κB/miR-155-5p/MDR1 Pathway, Journal of Agricultural and Food Chemistry, 2019,67(9):2510–2518.

2. Xiaoqin La, Lichao Zhang, Zhuoyu Li, et al. Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells, Oncotarget, 2017,8(13):20909-20924.

3. Xiaoqin La, Lichao Zhang, Hanqing Li, et al. Ajuba receptor mediates the internalization of tumor-secreted GRP78 into macrophages through different endocytosis pathways, Oncotarget, 2018,9(21):15464-15479.

4. Lichao Zhang^#, Xiaoqin La^#, Jinmiao Tian, Hanqing Li, Aiping Li, Yizhi Liu, Changxin Wu, Zhuoyu Li*, The phytochemical vitexin and syringic acid derived from foxtail fillet bran inhibit breast cancer cells proliferation via GRP78/SREBP-1/SCD1 signaling axis, Journal of Functional Foods. 2021, 85, 104620.

5. Yufei Yang, Lichao Zhang, Xiaoqin La, et al. Salvianolic acid A inhibits tumor-associated angiogenesis by blocking GRP78 secretion, Naunyn-Schmiedeberg's Archives of Pharmacology, 2018,392(4):467-480.

6. Lichao Zhang, Zongwei Li, Tonglin Shi, Xiaoqin La, et al. Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic for targeting cancer cells, BMC Biotechnology, 2016,16(1):65.

7. Lichao Zhang, Zongwei Li, Guobin Ding, Xiaoqin La, et al. GRP78 plays an integral role in tumor cell inflammation-related migration induced by M2 macrophages, Cellular Signalling, 2017, 37:136-148.

Scientific Research Project:

1. National Natural Science Foundation of China, General Program, 32072220, Molecular mechanism of p-coumaric acid and ferulic acid from Foxtail millet bran regulating GLP-1 to improve glucose and lipid metabolism disorder, 2021-01-2024-12, 580K, Runing Projects, Participated;

2. Scientific and Technological Innovation Project of Colleges and Universities in Shanxi Province, Molecular mechanism of millet bran polyphenols inhibiting breast cancer cell proliferation by regulating lipid metabolism (2020L0045)，2020.03-2022.02, 20K, Runing Projects, Project Director;

3. Key Research and Development Program of Shanxi Province, Mechanism of GRP78 promoting tumor development by regulating fatty acid oxidative metabolism (201903D421055), 2019.12-2022.12, 100K, Runing Projects, Participated;

4. Applied Basic Research Program of Shanxi Province, Study on the mechanism of bound polyphenol of inner shell inhibiting breast cancer cell proliferation by regulating lipid metabolism (201901D211128), 2019.09-2022.09, 30K, Runing Projects, Project Director;

5. Teaching Reform and Innovation Project of Higher Education in Shanxi Province, J2021058, Exploration and practice of cell biology curriculum construction based on "four-dimensional" hybrid teaching reform, 2021/8-2023/8, Runing Projects, Project Director;

6. Applied Basic Research Program of Shanxi Province, Mechanism of tumor secreted GRP78 promoting M2 polarization of macrophages by regulating lipid metabolism (201801D221249), 2018.12-2020.12, 30K, has been finished, Participated;

7. Graduate Education Innovation Project of Shanxi Province, Molecular mechanism of tumor secretory GRP78 through Ca²⁺ binding to macrophage recruitment (2018BY023), 2018.06-2019.06, 10K, has been finished, Project Director.