Lichao Zhang   Ph.D
	Associate professor   Master Supervisor
	Email: zlc@sxu.edu.cn

 

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Education and work experience

Aug 2017-present     Institutes of Biomedical Sciences Shanxi University, Lecturer

Sep 2012-Jul 2017      Shanxi University, Ph.D

Sep 2008-Jul 2012      Shanxi University, Bioscience

 

Areas of interests

      My research investigates the molecular biological mechanisms of specific biomolecules (eg, glucose regulator protein 78, GRP78) on tumor progression, and design drug to target  these specific molecules. In addition, I extracte and selecte small molecule anti-tumor drugs from natural product. The current research focuses on:

1. The role of GRP78 in the process of interacting between tumor cells and tumor microenvironment

2. Screening and mechanism-researching of anti-tumor small molecules in natural products

 

Major Enrollment:

1. Academic master: Biochemistry and molecular biology, genetics

2. Professional master: Bioengineering, Food engineering, Food processing and safety

Publications

1.   Lichao Zhang, Zongwei Li, Guobin Ding, Xiaoqin La, Peng Yang, Zhuoyu Li. GRP78 plays an integral role in tumor cell inflammation-related migration induced by M2 macrophages. Cellular Signalling.2017；37：136-48. IF：4.32

2.   Lichao Zhang, Zongwei Li, Tongli Shi, Xiaoqin La, Hanqing Li, Zhuoyu Li. Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic for targeting cancer cells. BMC biotechnology. 2016; 16:1-13. IF：2.45

3.   Lichao Zhang, Zongwei Li, Yongsheng Fan, Hanqing Li, Zhuoyu Li, Yaoping Li. Overexpressed GRP78 affects EMT and cell-matrix adhesion via autocrine TGF-beta/Smad2/3 signaling. The international journal of biochemistry & cell biology. 2015; 64:202-11. IF：3.91

4.   Xiaoqin La#, Lichao Zhang#, Zhuoyu Li, Peng Yang, Yingying Wang. Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells. Oncotarget. 2017; 8:20909-24. IF：5.99

5.   Zongwei Li#, Lichao Zhang#, Hanqin Li, Shuhua Shan, Zhuoyu Li. Glucose regulated protein 78 promotes cell invasion via regulation of uPA production and secretion in colon cancer cells. BMB Reports. 2014; 47:445-50. IF：2.78

6.   Zongwei Li, Lichao Zhang, Yarui Zhao, Hanqing Li, Hong Xiao, Rong Fu, et al. Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion. The international journal of biochemistry & cell biology. 2013; 45:987-94. IF：3.91

7.   Zongwei Li, Ming Zhuang, Lichao Zhang, Xingnan Zheng, Peng Yang, Zhuoyu Li. Acetylation modification regulates GRP78 secretion in colon cancer cells. Scientific reports. 2016; 6:30406. IF：5.22

8.   Zongwei Li, Yingying Wang, Haili Wu, Lichao Zhang, Peng Yang. GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the β-catenin signaling. Oncotarget. 2014. IF：5.00

9. Zongwei Li, Yingying Wang, Ian P. Newton, Lichao Zhang, Penyu Ji, Zhuoyu Li. GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKbeta. Cellular signalling. 2015; 27:1237-45. IF：4.19