 |
Zhuoyu Li PhD |
| Teach Doctoral Supervisor | |
| Email：lzy@sxu.edu.cn |
Education
2003.02-2009.09 Postdoctor，University Dundee，UK， engaged in research about Wnt signal pathway
1997.09-2002.03 PhD ，Department of Biochemistry ，University Kaiserslautern, Germany
1993.09-1997.09 Master，College of Biotechnology，Shanxi University, China 1982.09-1986.07 Bachelor ，Shanxi University, China
Work Experience
2017-so far President，College of Biotechnology，Shanxi University
2009.09- so far tutor for PhD，Shanxi University
2002.09- so far Professor，Shanxi University
1996.09-2002.09 Associate Professor，Shanxi University
1991.07-1996.08 Lecturer，Shanxi University
1986.07-1991.06 Assistant，Shanxi University
Research Fields
Regulation mechanism of energy metabolism and key proteins of signal transduction in tumor cells;
Extraction of functional molecules and the antitumor molecular mechanism in natural products;
Molecular toxicology and target screening of environmental factors induced tumor
Honors
2017: The first prize of Science and Technology Award in Shanxi Province (natural science)
2017: The first prize of the second national college student life science innovation and entrepreneurship contest
2016: The first prize of University Scientific and Technological Achievements Award in Shanxi Province
2016: China Industry University Cooperation Innovation Award
2014: National Excellent Scientific and Technical Workers
2014: the sixth Shanxi top ten outstanding young and middle-aged scientists and technicians"
2013: the seventh outstanding scientific and technological workers in Shanxi
2013: Zhejiang Qianjiang scholars"
2013: Shanxi "131" leading talent
2012: Shanxi academic and technical leaders
2010: Shanxi hundred people plan to introduce overseas talent
2010: Shanxi science and Technology Award "advanced individual two prize"
2010: the first prize of Natural Science Award of Shanxi province higher education scientific and Technological Achievement Award
2010: the three prize of natural science of Shanxi province (Shanxi science and Technology Department)
Representative Achievements
Research projects
2018.01-2021.12: the National Fund（600 thousand），Item Number: 31770382
2015.11-2018.11: Research Project Supported by Shanxi Scholarship Council of China (300 thousand)
2015.01-2015.12: Host Shanxi Platform Project (150 thousand), Item Number: 2015091015
2013-2016: In charge of the National Fund (850 thousand), Item Number: 31271516
2011-2012: In charge of the National Fund (150 thousand), Item Number: 81150026
2011-2014: Responsible for a Ph.D. Fund of Higher Education (120 thousand), Item Number: 20111401110011
2010-2011: In charge of the National Fund (100 thousand), Item Number: 31040018
2010-2013: Responsible for supporting the project of Shanxi overseas 100 people (1 million), has been a problem
2010-2012: Responsible for Hosting a Fund for Studying in Shanxi Province (100 thousand); Provincial Talent Introduction (300 thousand)
2003-2005: Host Shanxi Platform Project (has been a problem), Item Number: 30270292
1997-2003: Presided over a number of Shanxi Provincial Youth Fund; Shanxi Provincial Natural Science Foundation; Shanxi overseas education fund
Publications:
1. Shuhua Shan, Jiangying Shi, Peng Yang, Bin Jia, Haili Wu, XiaoLi Zhang, Zhuoyu Li*. Apigenin restrains colon cancer cell proliferation via targetedly blocking the PKM2-dependent glycolysis. Journal of Agricultural and Food Chemistry. 2017. DOI: 10.1021/acs.jafc.7b02757. IF: 3.154
2. Wu, H., T. Zhang, F. Pan, C. J. Steer, Zhuoyu Li, X. Chen and Guisheng Song. MicroRNA-206 prevents hepatosteatosis and hyperglycemia by facilitating insulin signaling and impairing lipogenesis. J Hepatol. 2017, 66(4): 816-824. IF: 12.486
3. Wu, H., J. Tao, X. Li, T. Zhang, L. Zhao, Y. Wang, L. Zhang, J. Xiong, Z. Zeng, N. Zhan, C. J. Steer, L. Che, M. Dong, X. Wang, J. Niu, Zhuoyu Li, G. Yan, X. Chen and Guisgeng Song. MicroRNA-206 Prevents the Pathogenesis of Hepatocellular Carcinoma Via Modulating Expression of cMet and Cdk6. Hepatology. 2017, doi: 10.1002/hep.29374. IF: 13.246
4. Jiangying Shi#, Shuhua Shan#, Hanqing Li, Guisheng Song, Zhuoyu Li*. Anti-inflammatory effects of millet bran derived-bound polyphenols in LPS-induced HT-29 cell via ROS / miR-149 / Akt / NF-κB signaling pathway. Oncotarget. 2017. DOI:10.18632/oncotarget. 20216. IF: 5.168
5. Xiaoqin La, Lichao Zhang, Zhuoyu Li, Peng Yang, Yingying Wang. Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells. Oncotarget. 2017, 8 (13): 20909-20924. IF: 5.168
6. Lichao Zhang, Zongwei Li, Guobin Ding, Xiaoqin La, Peng Yang, Zhuoyu Li*. GRP78 plays an integral role in tumor cell inflammation-related migration induced by M2 macrophages. Cellular signalling. 2017, (37): 136-148. IF: 4.4
7. Ruijun Su, Xiaoting Jin, Weifang Zhang, Zhuoyu Li*, Xiaona Liu, Jie Ren. Particulate matter exposure induces the autophagy of macrophages via oxidative stress-mediated PI3K/AKT/mTOR pathway. Chemosphere. 2017, 167, 444-453. IF 3.69
8. Li Song, Linlin Guo, Zhuoyu Li*. Molecular mechanisms of 3,3′4,4′,5-pentachlorobiphenyl-induced epithelial-mesenchymal transition in human hepatocellular carcinoma cells. Toxicology and Applied Pharmacology. 2017, 322, 75-88. IF 3.847
9. Yingying Wang#, Haili Wu#, Peng Yang, Zongwei Li, Zhuoyu Li*. A positive feedback loop between GRP78 and VPS34 is critical for GRP78-mediated autophagy in cancer cells. Experimental Cell Research. 2017, 351 (1): 24-35. IF: 3.378
10. Zongwei Li, Ming Zhuang, Lichao Zhang, Xingnan Zheng, Peng Yang, Zhuoyu Li*. Acetylation modification regulates GRP78 secretion in colon cancer cells. Scientific Reports. 2016; 6: 30406-30417. IF: 5.228
11. Haili Wu, Peng Yang, Wanglai Hu, Yingying Wang, Yangxu Lu,Lichao Zhang, Yongsheng Fan, Hong Xiao, Zhuoyu Li*. Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stability. Oncotarget. 2016, 7 (47): 78069-78082. IF: 5.168
12. Haili Wu, Yingying Wang, Changxin Wu, Peng Yang, Hanqing Li, Zhuoyu Li*. Resveratrol induced cancer cell apoptosis through miR-326/PKM2 mediated ER stress and mitochondrial fission. Journal of Agricultural and Food Chemistry. 2016, 64 (49): 9356-9367. IF: 3.154
13. Haili Wu, Yingying Wang, Peng Yang, Zongrui Li, Hanqing Li, Changxin Wu, Zhuoyu Li*. MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion. American Journal of Cancer Research. 2016, 6 (10): 2221-2234. IF: 3.425
14. Lichao Zhang, Zongwei Li, Tonglin Shi, Xiaoqin La, Hanqing Li, Zhuoyu Li*. Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic for targeting cancer cells. BMC biotechnology. 2016, 16(1): 1-13. IF: 2.45
15. Xiaoting Jin, Ruijun Su, Ruijin Li, Li Song, Meilan Chen, Long Cheng, Zhuoyu Li*. Amelioration of particulate matter-induced oxidative damage by vitamin c and quercetin in human bronchial epithelial cells. Chemosphere. 2016,144,459-466. IF 3.69
16. Xiaoting Jin, Meilan Chen, Ruijin Li, Quan An, Li Song, Yi Zhao, Hong Xiao, Long Cheng, Zhuoyu Li*. Progression and inflammation of human myeloid leukemia induced by ambient PM2.5 exposure. Archives of Toxicology. 2016, 90(8), 1929-1938. IF 6.68
17. Xiaoting Jin, Li Song, Zhuoyu Li*, Ian P. Newton, Meirong Zhao M, Weiping Liu. Dichlorodiphenyldichloroethylene Dichlorodi exposure reduces r-GCS via suppressed Nrf2 in HepG2 cells. Environ Toxicol. 2016, 31(3): 350-359. IF 2.7
18.Min Guo, GuoBin Ding, Peng Yang, Lichao Zhang, Haili Wu, Hanqing Li, Zhuoyu Li*. Migration Suppression of Small Cell Lung Cancer by Polysaccharides from Nostoc commune Vaucher. J. Agric. Food Chem. 2016, 64, 6277-6285. IF 3.154
19. Li Song, Jiao Chang and Zhuoyu Li*.A serine protease extracted from Trichosanthes kirilowii induces apoptosis via the PI3K/AKTmediated mitochondrial pathway in human colorectal adenocarcinoma cells. Food & Function. 2016, 7(2): 843-54. IF 2.791
20. Tonglin Shi, Cao Zhao Zhuoyu Li*, Quanbin Zhang, Xiaoting Jin. Bisphenol A exposure promote the migration of NCM460 cells via estrogen receptor-mediated integrin β1/MMP-9 pathway. Environ Toxicol. 2016, 31(7): 799-807. IF 2.7
21. Peng Yang, Zhuoyu Li, Hanqing Li*, Potential roles of proteases inhibitors in cancer progression. Asian Pac J Cancer Prev. 2015, 16 (18), 8047-8052. IF 2.514
22. Jiangying Shi, Shuhua Shan, Zongwei Li, Hanqing Li, Xinfeng Li, Zhuoyu Li*. Bound polyphenol from foxtail millet bran induces apoptosis in HCT-116 cell through ROS generation. Journal of functional foods. 2015,17: 958-968. IF 3.57
23. Peng Yang, Zongwei Li, Hanqing Li, Yangxu Lu, Haili Wu, Zhuoyu Li*. Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer. Cellular Signalling. 2015, 27: 1525-1532. IF 4.4
24. Peng Yang, Zongwei Li, Yingying Wang, Lichao Zhang, Haili Wu, Zhuoyu Li*. Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells. Biochemical and Biophysical Research Communications, 2015, 459(2), 327-332. IF 2.4
25. Shuhua Shan, Jiangying Shi, Zhen Li, Huixiang Gao, Tonglin Shi, Zongwei Li, Zhuoyu Li*. Targeted anti-colon cancer activities of a millet bran-derived peroxidase were mediated by elevated ROS generation. Food Funct. 2015, 6(7): 2331-2338. IF 2.7
26. Min Guo, Guobin Ding, Songjia Guo, Zhuoyu Li*, Liangqi Zhao, Ke Li, Xiangrong Guo. Isolation and antitumor efficacy evaluation of a polysaccharide from Nostoc commune Vauch. Food Funct. 2015, 6, 3035-3044. IF 2.7
27. Tonglin Shi, Lichao Zhang, Zhuoyu Li*, Ian P Newton Quanbin Zhang. Expression, purification and renaturation of truncated human integrin β1 from inclusion bodies of Escherichia coli. Protein Expr Purif. 2015, 107:13-19. IF 2.8
28. Zongwei Li, YingyingWang, Ian P. Newton, Lichao Zhang, Pengyu Ji, Zhuoyu Li*. GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ. Cellular Signalling. 2015, 27: 1237-1245. IF 4.4
29. Songjia Guo, Shuhua Shan, Xiaoting Jin, Zongwei Li, Zhuoyu Li*, Lichao Zhao, Quan An, Wei Zhang. Water Stress Proteins from Nostoc commune Vauch. Exhibit Anti-Colon cancer activities in Vitro and in Vivo. J Agric Food Chem. 2015, 63(1): 150-159. IF 3.1
30. Lichao Zhang, Zongwei Li, Yongsheng Fan, Hanqing Li*, Zhuoyu Li*,Yaoping Li. Overexpressed GRP78 affects EMT and cell-matrix adhesion viaautocrine TGF-β/Smad2/3 signaling. Int J Biochem Cell Biol. 2015, 64, 202-211. IF 4.5
31. Li Song, Meirong Zhao, Jianxin Liu, Zhuoyu Li*, Hong Xiao, Weiping Liu. p, p’- Dichlorodiphenyltrichloroethane inhibits the apoptosis of colorectal adenocarcinoma DLD1 cells through PI3K/AKT and Hedgehog/Gli1 signaling pathways. Toxicology Research. 2015, 4, 1214-1224. IF 3.983
32. Li Song, Zhuoyu Li*, Wei-Ping Liu, Mei-Rong Zhao. Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy. Cancer Biology & Therapy. 2015, 16, 1-7. IF 3.072
33. Tonglin Shi, Zongwei Li, Quanbin Zhang, Dawen Zheng and Zhuoyu Li*. Pluronic F127 as a drug vehicle used in chick embryo chorioallantoic membrane shell-less model.Pak J Pharm Sci. 2015, 28: 1997-1999. IF 0.682
34. Zongwei Li, Yingying Wang, Haili Wu, Lichao Zhang, Peng Yang, Zhuoyu Li*. GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the β-catenin signaling. Oncotarget. 2014, 30; 5(14): 5369-5380. IF 6.6
35. Li Song, Jianxin Liu, Zhuoyu Li*, Meirong Zhao, Weiping Liu. P’-dichlorodiphenyl-dichloroethylene induces colorectal Adenocarcinoma Cell Proliferation through Oxidative Stress. PLoS One. 2014, 9(11): e112700. doi: 10.1371/. IF 3.7
36. Shuhua Shan, Zongwei Li, Songjia Guo, Zhuoyu Li*, Tonglin Shi, Jiangying Shi. A millet bran-derived peroxidase inhibits cell migration by antagonizing STAT3-mediated epithelial-mesenchymal transition in human colon cancer. Journal of functional foods. 2014, 10: 444-455. IF 4.4
37. Li song, Junyu Zhao, Xiaotiing Jin, Zhuoyu Li*, Ian P Newton, Weiping Liu, Hongxiao, Meirong Zhao. The organochlorine p,p'-dichlorodiphenyltrichloroethane induces colorectal cancer growth through Wnt/β-catenin signaling. Toxicol Lett. 2014, 229(1): 284-91. IF 3.2
38. Li Song, Yuxin Jia, Wensi Zhu, Ian P Newton, Zhuoyu Li*, Wenlin Li. N-terminal trunctions of adenomatous polyposis coli are associated with primary cilia defects. Int J Biochem Cell Biol. 2014, 21(55): 79-86. IF 4.5
39. Yanan Peng, Zongwei li, Peng Yang, Ian P Newton, Hua Ren, Lichao Zhang, Haili Wu, Zhuoyu Li*. Direct contacts with colon cancer cells regulate the differentiation of bone marrow mesenchymal stem cells into tumor associated fibroblasts. Biochem Biophys Res Commun. 2014, 451(1): 68-73. IF 8.8
40. Haili wu, Zongwei Li, Peng Yang, Lichao Zhang, Yongsheng fan, Zhuoyu Li*, PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cells. Cell Signal. 2014, 26(11): 2397-405. IF 4.4
41. Zongwei Li, Peng Yang, Zhuoyu Li*. The multifaceted regulation and functions of PKM2 in tumor progression. BBA-reviews on cancer. 2014, 1846(2): 285-296. IF 8.8
42. Xiaoting Jin, Meilan Chen, Li Song, Hanqing Li, Zhuoyu Li*. The evaluation of p,p'-DDT exposure on cell adhesion of hepatocellular carcinoma. Toxicology, 2014, 322: 99-108. IF 3.8
43. Xiaoting Jin, Li Song, Junyu Zhao, Zhuoyu Li*, Meirong Zhao, Weiping Liu. Dichlorodiphenyltrichloroethane exposure induces the growth of hepatocellular. Toxicology letters. 2014, 225:158-166. IF 3.2
44. Peng Yang, Zongwei Li, Rong Fu, Haili Wu, Zhuoyu Li*. Pyruvate kinase M2 facilites colon cancer migration via the modulation of ATAT3 signaling. Cellular signaling. 2014, 26(9): 1853-1862. IF 4.4
45. Shuahua Shan, Zongwei Li, Ian P. Newton, Chao Zhao, Zhuoyu Li*, Maolin Guo. A novel protein extraxted from foxtail millet bran displays anti-carcinogenic effects in human colon cancer cells. Toxicology letters. 2014, 227: 129-138. IF 3.2
46. Rong Fu, Yang Peng, Haili Wu, Zongwei, Li, Zhuoyu Li*, GRP78 secreted by colon cancer cells facilitates cell proliferation via PI3K/AKT signaling. Asian Pacific Journal of Cancer Prevention. 2014, 15 (17): 7245-7249. IF 1.7
47. Zongwei Li, Lichao Zhang, Hanqing Li, Shuhua Shan, Zhuoyu Li*. Glucose regulated protein 78 promotes cell invasion via regulation of uPA production and secretion in colon cancer cells. BMB Rep. 2014,47(8): 445-450. IF 1.7
48. Zongwei Li, Chao Zhao, Zhuoyu Li*, Yarui Zhao, Shuhua Shan, Tonglin Shi, Jianguo Li. Reconstructed mung bean trypsin inhibitor targeting cell surface GRP78 induces apoptosis and inhibits tumor growth in colorectal cancer. Int J Biochem Cell Biol, 2014, 47: 68-75. IF 4.5
49. Xiaoting Jin, Li Song, Xiangyuan Liu, Meilian Chen, Zhuoyu Li*, Long Cheng, Hua Ren. Protective efficacy of Vitamins C and E on p,p’-DDT-induced cytotoxicity via the ROS –mediated mitochondrial pathway and NF-kB/FasL pathway. PLoS One. 2014 Dec 9(12): e113257. doi: 10.1371/. IF 3.7
50. Yanan Peng, Zongwei Li, Zhuoyu Li*. GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer-associated fibroblasts. Biochemical and Biophysical Research Communications, 2013, 440(4): 558-63. IF 2.5
51. Zongwei Li, Lichao Zhang, Yarui Zhao, Hanqing Li, Hong Xiao, Rong Fu, Zhuoyu Li*. Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion. Int J Biochem Cell Biol, 2013, 45(5): 987-994. IF 4.5
52. Cui Wang, Zhuoyu Li, Quan Zhang, Meirong Zhao, Weipiing Liu. Enantioselective induction of cytotoxicity by o,p'-DDD in PC12 cells: implications of chairality in risk assessment of POPs metabolisms. Environ Sci Technol. 2013, 6; 47(8): 3909-3917. IF 5.1
53. Zhuoyu Li*, Wenling Li, Wensi Li, Li Song, Cilia, adenomatous polyposis coli and associated diseases. Oncogene, 2012, 31(12): 1475-83. IF 8.5
54. Zongwei Li, Zhuoyu Li*. Glucose regulated protein 78: a critical link between tumor microenvironment and cancer hallmarks. BBA-reviews on cancer. 2012, 1826(1): 13-22．IF 8.8
55. Scott A Nelson, Zhuoyu Li, Ian P Newton，David Schiffmann，Cornelis J. Weijer，Paul L. Appleton，Inke S. N?thke，Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems. Disease Models & Mechanisms，2012, 5(5): 1-7. IF 4.5
56. Lixi Niu, Chenyun Guo, Jingming Yuan, Zhuoyu Li*, Potential roles of recombinant acetylcholine receptor α subunit 1-211 in immunoadsorbent and DNA immunization. J Immunol Methods, 2011 30; 372(12): 14-21. IF 2.340
57. Yingqi Li, Zhuoyu Li*, Xueping Zhou, Pin Yang. Detection of Nano Eu2O3 in cells and study of its biological effects. Nano Biomed Eng, 2010, 2(1):32-45. IF 1.3
58. Dina Dikovskaya, Zhuoyu Li, Ian P Newton, Iain Davision, Paul Clacke and Inke S Nathke. Microtubule assmbly by the Apc protein is regulated by importin-β-RanGTP, Journal of Cell Science, 2010, 123: 1242-1253. IF 6.290
59. Zhuoyu Li, Karin Kroboth, Ian P Newton, Inke S Nathke. Novel self-association of NH2-terminal regions of the Adenomatous polyposis coli protein regulates APC cluster formation and cell migration. Journal of Cell Science, 2008, 121: 1916-1925. IF 6.290
60. Zhuoyu Li*, Yanfeng Qu, Hanqing Li, Jingming Yuan. Truncations of gelonin lead to a reduction in its cytotoxicity. Toxicology， 2007, 7; 231(2-3): 129-136. IF 3.641
61. Kroboth, K, Newton, I.P, Zumbrunn, J, Zhuoyu, Li, Kita, K, Waterman-Storer, C.M, N?thke, I.S. Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol. Biol. Cell, 2007,18: 910-918. IF 5.861
62. Martin Hossan; Zhuoyu Li, Yawei Shi, Ulrike Kreilinger, Jorn Butter, Pia D Vogel, Jingming Yuan, John Wise, Wolfgang E. Trommer, Novel immunotoxin: a fusion protein consisting of gelonin and acetylcholine receptor fragment as a potential immunotherapeutic agent for the treatment of Myasthenia gravis. Protein Expression and Purification, 2006, 46: 73-84. IF 1.644
63. Zhuoyu Li, Inke S N?thke. Tumor-associated NH2-terminal fragments are the most stable part of the Adenomatous Polyposis Coli protein and can be regulated by interactions with COOH-terminal domains, Cancer Research, 2005, 65 (12): 5195-5204. IF 9.234
Patent granted
1. The preparation method and the application of 1 malvae protein: 201410238318.3, ranked first
2. One kind of Auricularia auricula anti-tumor polysaccharide and its preparation method and application: 201410459857.X, ranking first
3. The preparation and application of 3, a county water stress protein gene and its recombinant protein was 201310291766.5, ranking first
4. Trypsin inhibitor and its preparation method and application: 201210012186.3, ranking first
5. A kind of antitumor activity of bran protein and preparation method and application thereof: 201210084106, ranked first
6. Trypsin inhibitor active fragment derivative and its preparation method and application: 201110313113.3, ranking first
7. A botanical pesticide and its production method and application: 201010259258.5, ranking second
8. Force growth factor polypeptide and its preparation method and use: 201010224435.6, ranking third
Genebank: a new gene (released in 2013 County water stress protein gene)
Serial number: KF 003026
Address: shanxi taiyuan basin city road 92 zip code: 030006 tel: 0351-7010255 Copyright shanxi university all rights reserved. All rights reserved: shanxi university For examination and approval of non-operational Internet information services (jin) ICP for 05000471 Webmaster@sxu.edu.cn
