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Changxin Wu Ph.D |
| Teach Doctoral Supervisor | |
| Email: cxw20@sxu.edu.cn |
Education
1983-1988: Bachelor Degree, Clinical Veterinary Medicine, Vet School Yangzhou University;
1988-1991: Master Degree, Preventive Veterinary Medicine, Vet School, Yangzhou University;
2002-2005: Doctor of Philosophy, Infection and Immunity, University of Cambridge
Research Experience
1991-1994: Teaching Assistant, Vet School, Yangzhou University,China
1994-1999: Lecturer, Vet School, Yangzhou University, China
1999-2000: Visiting Scholar, University of Cambridge, UK
2000-2001: Research Assistant, Department of Zoology, University of Cambridge, UK
2002-2005: Welcome Trust International Fellow, University of Cambridge, Institute of Animal Health, UK
2006-2009: Research Associate, Department of Medicine, School of Clinical Medicine, University of Cambridge, UK
2009-20012: Scientist, Department of Medicine, School of Clinical Medicine, University of Cambridge, UK
2012-2015: Senior Scientist, Department of Medicine, School of Clinical Medicine, University of Cambridge, Uk
2015- Professor of Infection and Immunity, Director of the Institutes of Biomedical Sciences, Shanxi University, China
My laboratories have long term interest in infection and immunity in humans and animals, such as mycobacterium tuberculosis, Mtb, in particular；We also interested in primary immunodeficiency in humans.
The mechanisms of susceptibility to infections in humans and domestic animals
My laboratories are investigating the mechanisms of susceptibility to infections in humans and domestic animals. We screen, identify and characterize genes in the host genome that carry sequence variants involved in resistance to infection and predispose to infectious diseases. Discovery of such genes can open new biological pathways and provide new targets for intervention. We use methods of genetics, including genome-wide association studies (GWAS) and the 1st , 2nd and 3rd generation sequencing, establish and apply in vitro and in vivo models of infections and techniques of molecular and cellular biology to understand underlying biological mechanisms protecting from infections.
Investigation into genetics of susceptibility to tuberculosis and elucidation of biological mechanisms involved host susceptibility to TB
We currently focus on susceptibility to tuberculosis (TB) and mycobacterial infection. Our groups consist of TB clinicians in hospitals, scientists in the national or local Center for Disease Control (CDC) and experts in human genetics and other mycobacterial research institutes in China. In collaboration with the labs of infectious disease division in Medicine Department, School of Clinical Medicine and Veterinary Science Center in the Department of Veterinary，Vet School, Cambridge University and related labs in other western universities or institutes, we perform functional analysises of the genes in cellular and animal models to elucidate the mechanisms of genetic variants affecting the susceptibility to TB at molecular and cellular levels after screening human genes associated with TB susceptibility using genetics approaches. These researches will reveal human genes that predispose to or protect from TB and may highlight new pathways that are involved in control of M. tuberculosis infection and progression to pulmonary TB. We will also combine information obtained in these experiments to investigate interaction between human genes that predispose to TB and virulence factors of mycobacteria during TB development. Eventually, our goals are to lead to better understanding of TB pathogenesis and may develop of new interventions and therapeutics to treat infections, and generate new strategies for TB effective prevention, control and therapy.
Genetic analyses of patients with rare diseases and primary Immunodeficiencies
Taking advantage of the highest incidence of rare diseases and very rich biomedical resources in Shanxi , China, we apply genetic approaches to screen genetic variants which are causative to rare diseases. My labs are particularly interested in Primary Immunodeficiencies (PIDs) comprise a heterogeneous group of genetic disorders that affect functions of the immune system and manifest as severe and/or recurrent infections. Mutations in more than human 200 genes are known to cause various PIDs. We study PID patients in collaboration with clinicians and clinical scientists working at hospitals in Shanxi Province and across China. We use whole exome sequencing to search for causative mutations, followed by detailed functional molecular analyses of the affected cellular pathways in vitro and in vivo models in the Institutes of Biomedical Sciences (IBMS), Shanxi University, China.
Collaborators
Dr Han Xiao (Lab of rare disease, IBMS)
Dr Zhonghua Zhao ( Lab of Zebrafish, IBMS )
Dr Qiuhong Xiong (Lab of Infection and immunity, IBMS）
Dr Ping Li (Lab of rare disease, IBMS )
Dr Qinglai Meng (Lab of Infectious Diseases, IBMS)
Professor Yaowu Zheng ( Center for Experimental Animal, IBMS)
Professor Jinpei Ye (Lab Stem Cell biology, IBMS)
Professor Cheng Chuanfu (Division of Animal Infectious Diseases, Shehezi University, China
Professor Nianshu Zhang （Department of Biochemistry, Cambridge)
Professor Ian McConnell (Center for Veterinary Medicine, Cambridge)
Professor Sergey Nejestev (TB Lab, Medical School, Cambridge)
Professor John Sinclair (Division of Infectious Diseases, Cambridge)
Professor Barbara Blacklaws (Division of Infection and Immunity, Cambridge)
Selected Publications
1，MiR-106b-mediated MfN2 suppression is critical for PKM2 induced mitochondrial fusion Haili Wu Zhuoyu Li, Yingying Wang, Peng Yang, Zongrui Li, Hangqing Li, Changxin Wu Am J Cancer Research 2016; 6(8）
2 Curtis J, Luo Y, Zenner HL, Cuchet-Louren?o D, Wu C, Lo K, Maes M, Alisaac A, Stebbings E, Liu JZ, Kopanitsa L, Ignatyeva O, Balabanova Y, Nikolayevskyy V, Baessmann I, Thye T, Meyer CG, Nürnberg P, Horstmann RD, Drobniewski F, Plagnol V, Barrett JC, Nejentsev S. Susceptibility to?tuberculosis?is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration. Nat Genet. 2015 May;47(5):523-7.
3 Angulo I1, Vadas O, Gar?on F, Banham-Hall E, Plagnol V, Leahy TR, Baxendale H, Coulter T, Curtis J, Wu C, Blake-Palmer K, Perisic O, Smyth D, Maes M, Fiddler C, Juss J, Cilliers D, Markelj G, Chandra A, Farmer G, Kielkowska A, Clark J, Kracker S, Debré M, Picard C, Pellier I, Jabado N, Morris JA, Barcenas-Morales G, Fischer A, Stephens L, Hawkins P, Barrett JC, Abinun M, Clatworthy M, Durandy A, Doffinger R, Chilvers ER, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe A, Nejentsev S. Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Science 2013 Nov 15;342(6160):866-71.
6 Wu Changxin, Junji Gan, Qiao Jin, Chuangfu Chen, Ping Liang, Li MaXuefan Liu and Fred David. Productive replication of revaccinated Marek’s disease virus and its induction of superior immunity against Marek’s disease. Clinical and Vaccine Immunology. 2009 Feb;16(2):184-93.
7 Wu Changxin, Cyril Barbezange, Ian McConnell and Barbara Blacklaws. Mapping and characterization of visan/maedi virus cytotoxic T-lymphocyte epitopes. J. Gen Virol. 2008 Oct;89:2586-96.
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