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李卓玉
李卓玉 博士
教授 博士生导师
联系方式:lzy@sxu.edu.cn

教育背景

2003.02-2009.09   英国邓迪大学博士后,从事肿瘤细胞Wnt信号的调控研究

1997.09-2002.03   德国凯塞斯劳滕大学,生物化学系,博士

1993.09-1997.09   山西大学生命科学学院,硕士(在职)

1982.09-1986.07   山西大学生命科学学院,学士

 

工作经历

2017-至今         山西大学生命科学学院,院长

2009.09-至今      山西大学,教授,博导

2002.09-至今      山西大学,教授

1996.09-2002.09   山西大学,副教授

1991.07-1996.08   山西大学,讲师

1986.07-1991.06   山西大学,助教

 

主要研究方向

1. 肿瘤发生发展的分子机制及其标靶的研究;

2. 天然产物来源的靶向抗肿瘤功能分子的研发;

3. 环境因子对肿瘤的毒性作用及其分子标靶研究。

 

代表性成果

承担的科研项目

1. 2018.01-2021.12: 负责国家自然科学基金一项(60万),项目编号:31770382

2. 2015.11-2018.11:负责山西省回国留学人员科研资助项目(30万),项目编号:2015-重点2

3. 2015.01-2015.12:主持山西省平台项目(15万), 项目编号:2015091015

4. 2013-2016:负责主持国家自然科学基金一项(85万),项目编号:31271516

5. 2011-2012:负责主持国家基金一项(15万), 项目编号:81150026

6. 2011-2014:负责主持高等学校博导基金一项(12万) 项目编号:20111401110011

7. 2010-2011:负责主持国家基金一项(10万), 项目编号:31040018

8.  2010-2012:负责主持山西省留学基金一项 (10万);省人才引进专项(30万)

9. 2003-2005:负责主持国家基金一项 (20万),已结题,项目编号:30270292

10.  1997-2003:负责主持多个山西省青年基金;山西省自然科学基金;山西省留学基金


 代表学术论文:

1. Shuhua Shan, Jiangying Shi, Peng Yang, Bin Jia, Haili Wu, XiaoLi Zhang, Zhuoyu Li*. Apigenin restrains colon cancer cell proliferation via targetedly blocking the PKM2-dependent glycolysis. Journal of Agricultural and Food Chemistry. 2017. DOI: 10.1021/acs.jafc.7b02757. IF: 3.154

2. Wu, H., T. Zhang, F. Pan, C. J. Steer, Zhuoyu Li, X. Chen and Guisheng Song. MicroRNA-206 prevents hepatosteatosis and hyperglycemia by facilitating insulin signaling and impairing lipogenesis. J Hepatol. 2017, 66(4): 816-824.  IF: 12.486

3. Wu, H., J. Tao, X. Li, T. Zhang, L. Zhao, Y. Wang, L. Zhang, J. Xiong, Z. Zeng, N. Zhan, C. J. Steer, L. Che, M. Dong, X. Wang, J. Niu, Zhuoyu Li, G. Yan, X. Chen and Guisgeng Song. MicroRNA-206 Prevents the Pathogenesis of Hepatocellular Carcinoma Via Modulating Expression of cMet and Cdk6. Hepatology. 2017, doi: 10.1002/hep.29374. IF: 13.246

?4. Jiangying Shi#, Shuhua Shan#, Hanqing Li, Guisheng Song, Zhuoyu Li*. Anti-inflammatory effects  of  millet  bran  derived-bound polyphenols in LPS-induced HT-29 cell via ROS / miR-149 / Akt / NF-κB signaling pathway. Oncotarget. 2017. DOI:10.18632/oncotarget. 20216.  IF: 5.168

5. Xiaoqin La, Lichao Zhang, Zhuoyu Li, Peng Yang, Yingying Wang. Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells. Oncotarget. 2017, 8 (13): 20909-20924. IF: 5.168

6. Lichao Zhang, Zongwei Li, Guobin Ding, Xiaoqin La, Peng Yang, Zhuoyu Li*. GRP78 plays an integral role in tumor cell inflammation-related migration induced by M2 macrophages. Cellular signalling. 2017, (37): 136-148. IF: 4.4

7. Ruijun Su, Xiaoting Jin, Weifang Zhang, Zhuoyu Li*, Xiaona Liu, Jie Ren. Particulate matter exposure induces the autophagy of macrophages via oxidative stress-mediated PI3K/AKT/mTOR pathway. Chemosphere. 2017, 167, 444-453. IF 3.69

?8.  Li Song, Linlin Guo, Zhuoyu Li*. Molecular mechanisms of 3,3′4,4′,5-pentachlorobiphenyl-induced epithelial-mesenchymal transition in human hepatocellular carcinoma cells. Toxicology and Applied Pharmacology. 2017, 322, 75-88. IF 3.847

9. Yingying Wang#, Haili Wu#, Peng Yang, Zongwei Li, Zhuoyu Li*. A positive feedback loop between GRP78 and VPS34 is critical for GRP78-mediated autophagy in cancer cells. Experimental Cell Research. 2017, 351 (1): 24-35. IF: 3.37

10. Zongwei Li, Ming Zhuang, Lichao Zhang, Xingnan Zheng, Peng Yang, Zhuoyu Li*. Acetylation modification regulates GRP78 secretion in colon cancer cells. Scientific Reports. 2016; 6: 30406-30417. IF: 5.228

11. Haili Wu, Peng Yang, Wanglai Hu, Yingying Wang, Yangxu Lu,Lichao Zhang, Yongsheng Fan, Hong Xiao, Zhuoyu Li*. Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stability. Oncotarget. 2016, 7 (47): 78069-78082. IF: 5.168

12. Haili Wu, Yingying Wang, Changxin Wu, Peng Yang, Hanqing Li, Zhuoyu Li*. Resveratrol induced cancer cell apoptosis through miR-326/PKM2 mediated ER stress and mitochondrial fission. Journal of Agricultural and Food Chemistry. 2016, 64 (49): 9356-9367. IF: 3.154

13. Haili Wu, Yingying Wang, Peng Yang, Zongrui Li, Hanqing Li, Changxin Wu, Zhuoyu Li*. MiR-106b-mediated Mfn2 suppression is critical for PKM2 induced mitochondrial fusion. American Journal of Cancer Research. 2016, 6 (10): 2221-2234. IF: 3.425

14. Lichao Zhang, Zongwei Li, Tonglin Shi, Xiaoqin La, Hanqing Li, Zhuoyu Li*. Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic for targeting cancer cells. BMC biotechnology. 2016, 16(1): 1-13. IF: 2.45

15. Xiaoting Jin, Ruijun Su, Ruijin Li, Li Song, Meilan Chen, Long Cheng, Zhuoyu Li*. Amelioration of particulate matter-induced oxidative damage by vitamin c and quercetin in human bronchial epithelial cells. Chemosphere. 2016,144,459-466. IF 3.69

16. Xiaoting Jin, Meilan Chen, Ruijin Li, Quan An, Li Song, Yi Zhao, Hong Xiao, Long Cheng, Zhuoyu Li*. Progression and inflammation of human myeloid leukemia induced by ambient PM2.5 exposure. Archives of Toxicology. 2016, 90(8), 1929-1938. IF 6.68

17. Xiaoting Jin, Li Song, Zhuoyu Li*, Ian P. Newton, Meirong Zhao M, Weiping Liu. Dichlorodiphenyldichloroethylene Dichlorodi exposure reduces r-GCS via suppressed Nrf2 in HepG2 cells. Environ Toxicol. 2016, 31(3): 350-359. IF 2.7

18.Min Guo, GuoBin Ding, Peng Yang, Lichao Zhang, Haili Wu, Hanqing Li, Zhuoyu Li*. Migration Suppression of Small Cell Lung Cancer by Polysaccharides from Nostoc commune Vaucher. J. Agric. Food Chem. 2016, 64, 6277-6285.  IF 3.154

19. Li Song, Jiao Chang and Zhuoyu Li*.A serine protease extracted from Trichosanthes kirilowii induces apoptosis via the PI3K/AKTmediated mitochondrial pathway in human colorectal adenocarcinoma cells. Food & Function. 2016, 7(2): 843-54. IF 2.791

?20. Tonglin Shi, Cao Zhao Zhuoyu Li*,  Quanbin Zhang,  Xiaoting Jin. Bisphenol A exposure promote the migration of NCM460 cells via estrogen receptor-mediated integrin β1/MMP-9 pathway. Environ Toxicol. 2016, 31(7): 799-807. IF 2.7

21. Peng Yang, Zhuoyu Li, Hanqing Li*, Potential roles of proteases inhibitors in cancer progression. Asian Pac J Cancer Prev. 2015, 16 (18), 8047-8052. IF 2.514

22. Jiangying Shi, Shuhua Shan, Zongwei Li, Hanqing Li, Xinfeng Li, Zhuoyu Li*. Bound polyphenol from foxtail millet bran induces apoptosis in HCT-116 cell through ROS generation. Journal of functional foods. 2015,17: 958-968. IF 3.57

23. Peng Yang, Zongwei Li, Hanqing Li, Yangxu Lu, Haili Wu, Zhuoyu Li*. Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer. Cellular Signalling. 2015, 27: 1525-1532. IF 4.4

24. Peng Yang, Zongwei Li, Yingying Wang, Lichao Zhang, Haili Wu, Zhuoyu Li*. Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells. Biochemical and Biophysical Research Communications, 2015, 459(2), 327-332. IF 2.4

25. Shuhua Shan, Jiangying Shi, Zhen Li, Huixiang Gao, Tonglin Shi, Zongwei Li, Zhuoyu Li*. Targeted anti-colon cancer activities of a millet bran-derived peroxidase were mediated by elevated ROS generation. Food Funct. 2015, 6(7): 2331-2338. IF 2.7

26. Min Guo, Guobin Ding, Songjia Guo, Zhuoyu Li*, Liangqi Zhao, Ke Li, Xiangrong Guo. Isolation and antitumor efficacy evaluation of a polysaccharide from Nostoc commune Vauch. Food Funct. 2015, 6, 3035-3044. IF 2.7

27. Tonglin Shi, Lichao Zhang, Zhuoyu Li*, Ian P Newton Quanbin Zhang. Expression, purification and renaturation of truncated human integrin β1 from inclusion bodies of Escherichia coli. Protein Expr Purif. 2015, 107:13-19. IF 2.8

28. Zongwei Li, YingyingWang, Ian P. Newton, Lichao Zhang, Pengyu Ji, Zhuoyu Li*. GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKβ. Cellular Signalling. 2015, 27: 1237-1245. IF 4.4

29. Songjia Guo, Shuhua Shan, Xiaoting Jin, Zongwei Li, Zhuoyu Li*, Lichao Zhao, Quan An, Wei Zhang. Water Stress Proteins from Nostoc commune Vauch. Exhibit Anti-Colon cancer activities in Vitro and in Vivo. J Agric Food Chem. 2015, 63(1): 150-159. IF 3.1

30. Lichao Zhang, Zongwei Li, Yongsheng Fan, Hanqing Li*, Zhuoyu Li*,Yaoping Li. Overexpressed GRP78 affects EMT and cell-matrix adhesion viaautocrine TGF-β/Smad2/3 signaling. Int J Biochem Cell Biol. 2015, 64, 202-211. IF 4.5

31. Li Song, Meirong Zhao, Jianxin Liu, Zhuoyu Li*, Hong Xiao, Weiping Liu. p, p’- Dichlorodiphenyltrichloroethane inhibits the apoptosis of colorectal adenocarcinoma DLD1 cells through PI3K/AKT and Hedgehog/Gli1 signaling pathways. Toxicology Research. 2015, 4, 1214-1224. IF 3.983

32. Li Song, Zhuoyu Li*, Wei-Ping Liu, Mei-Rong Zhao. Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy. Cancer Biology & Therapy. 2015, 16, 1-7. IF 3.072

33. Tonglin Shi, Zongwei Li, Quanbin Zhang, Dawen Zheng and Zhuoyu Li*. Pluronic F127 as a drug vehicle used in chick embryo chorioallantoic membrane shell-less model.Pak J Pharm Sci. 2015, 28: 1997-1999. IF 0.682

34. Zongwei Li, Yingying Wang, Haili Wu, Lichao Zhang, Peng Yang, Zhuoyu Li*. GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the β-catenin signaling. Oncotarget. 2014, 30; 5(14): 5369-5380. IF 6.6

35. Li Song, Jianxin Liu, Zhuoyu Li*, Meirong Zhao, Weiping Liu. P’-dichlorodiphenyl-dichloroethylene induces colorectal Adenocarcinoma Cell Proliferation through Oxidative Stress. PLoS One. 2014, 9(11): e112700. doi: 10.1371/. IF 3.7

36. Shuhua Shan, Zongwei Li, Songjia Guo, Zhuoyu Li*, Tonglin Shi, Jiangying Shi. A millet bran-derived peroxidase inhibits cell migration by antagonizing STAT3-mediated epithelial-mesenchymal transition in human colon cancer. Journal of functional foods. 2014, 10: 444-455. IF 4.4

37. Li song, Junyu Zhao, Xiaotiing Jin, Zhuoyu Li*, Ian P Newton, Weiping Liu, Hongxiao, Meirong Zhao. The organochlorine p,p'-dichlorodiphenyltrichloroethane induces colorectal cancer growth through Wnt/β-catenin signaling. Toxicol Lett. 2014, 229(1): 284-91. IF 3.2

38. Li Song, Yuxin Jia, Wensi Zhu, Ian P Newton, Zhuoyu Li*, Wenlin Li. N-terminal trunctions of adenomatous polyposis coli are associated with primary cilia defects.  Int J Biochem Cell Biol. 2014, 21(55): 79-86. IF 4.5

39. Yanan Peng, Zongwei li, Peng Yang, Ian P Newton, Hua Ren, Lichao Zhang, Haili Wu, Zhuoyu Li*. Direct contacts with colon cancer cells regulate the differentiation of bone marrow  mesenchymal stem cells into tumor associated fibroblasts. Biochem Biophys Res Commun. 2014, 451(1): 68-73. IF 8.8

40. Haili wu, Zongwei Li, Peng Yang, Lichao Zhang, Yongsheng fan, Zhuoyu Li*, PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in  tumor cells. Cell Signal. 2014, 26(11): 2397-405. IF 4.4

41. Zongwei Li, Peng Yang, Zhuoyu Li*. The multifaceted regulation and functions of PKM2 in tumor progression. BBA-reviews on cancer. 2014, 1846(2): 285-296. IF 8.8

42. Xiaoting Jin, Meilan Chen, Li Song, Hanqing Li, Zhuoyu Li*. The evaluation of p,p'-DDT exposure on cell adhesion of hepatocellular carcinoma. Toxicology, 2014, 322: 99-108. IF 3.8

43. Xiaoting Jin, Li Song, Junyu Zhao, Zhuoyu Li*, Meirong Zhao, Weiping Liu. Dichlorodiphenyltrichloroethane exposure induces the growth of hepatocellular. Toxicology letters. 2014, 225:158-166. IF 3.2

44. Peng Yang, Zongwei Li, Rong Fu, Haili Wu, Zhuoyu Li*. Pyruvate kinase M2 facilites colon cancer migration via the modulation of ATAT3 signaling. Cellular signaling. 2014, 26(9): 1853-1862. IF 4.4

45. Shuahua Shan, Zongwei Li, Ian P. Newton, Chao Zhao, Zhuoyu Li*, Maolin Guo. A novel protein extraxted from foxtail millet bran displays anti-carcinogenic effects in human colon cancer cells. Toxicology letters. 2014, 227: 129-138. IF 3.2

46. Rong Fu, Yang Peng, Haili Wu, Zongwei, Li, Zhuoyu Li*, GRP78 secreted by colon cancer cells facilitates cell proliferation via PI3K/AKT signaling. Asian Pacific Journal of Cancer Prevention. 2014, 15 (17): 7245-7249. IF 1.7

47. Zongwei Li, Lichao Zhang, Hanqing Li, Shuhua Shan, Zhuoyu Li*. Glucose regulated protein 78 promotes cell invasion via regulation of uPA production and secretion in colon cancer cells. BMB Rep. 2014,47(8): 445-450. IF 1.7

48. Zongwei Li, Chao Zhao, Zhuoyu Li*, Yarui Zhao, Shuhua Shan, Tonglin Shi, Jianguo Li. Reconstructed mung bean trypsin inhibitor targeting cell surface GRP78 induces apoptosis and inhibits tumor growth in colorectal cancer. Int J Biochem Cell Biol, 2014, 47: 68-75. IF 4.5

49. Xiaoting Jin, Li Song, Xiangyuan Liu, Meilian Chen, Zhuoyu Li*, Long Cheng, Hua Ren. Protective efficacy of Vitamins C and E on p,p’-DDT-induced cytotoxicity via the ROS –mediated mitochondrial pathway and NF-kB/FasL pathway. PLoS One. 2014 Dec 9(12): e113257. doi: 10.1371/. IF 3.7

50. Yanan Peng, Zongwei Li, Zhuoyu Li*. GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer-associated fibroblasts. Biochemical and Biophysical Research Communications, 2013, 440(4): 558-63. IF 2.5

51. Zongwei Li, Lichao Zhang, Yarui Zhao, Hanqing Li, Hong Xiao, Rong Fu, Zhuoyu Li*. Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion. Int J Biochem Cell Biol, 2013, 45(5): 987-994. IF 4.5

52. Cui Wang, Zhuoyu Li, Quan Zhang, Meirong Zhao, Weipiing Liu. Enantioselective induction of cytotoxicity by o,p'-DDD in PC12 cells: implications of  chairality in risk assessment of POPs metabolisms. Environ Sci Technol. 2013, 6; 47(8): 3909-3917. IF 5.1

53. Zhuoyu Li*, Wenling Li, Wensi Li, Li Song, Cilia, adenomatous polyposis coli and associated diseases. Oncogene, 2012, 31(12): 1475-83. IF 8.5

54. Zongwei Li, Zhuoyu Li*. Glucose regulated protein 78: a critical link between tumor microenvironment and cancer hallmarks. BBA-reviews on cancer. 2012, 1826(1): 13-22.IF 8.8

55. Scott A Nelson, Zhuoyu Li, Ian P Newton,David Schiffmann,Cornelis J. Weijer,Paul L. Appleton,Inke S. N?thke,Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems. Disease Models & Mechanisms,2012, 5(5): 1-7. IF 4.5

56. Lixi Niu, Chenyun Guo, Jingming Yuan, Zhuoyu Li*, Potential roles of recombinant acetylcholine receptor α subunit 1-211 in immunoadsorbent and DNA immunization. J Immunol Methods, 2011 30; 372(12): 14-21. IF 2.340

57. Yingqi Li, Zhuoyu Li*, Xueping Zhou, Pin Yang. Detection of Nano Eu2O3 in cells and study of its biological effects. Nano Biomed Eng, 2010, 2(1):32-45. IF 1.3

58. Dina Dikovskaya, Zhuoyu Li, Ian P Newton, Iain Davision, Paul Clacke and Inke S Nathke. Microtubule assmbly by the Apc protein is regulated by importin-β-RanGTP, Journal of Cell Science, 2010, 123: 1242-1253. IF 6.290

59. Zhuoyu Li, Karin Kroboth, Ian P Newton, Inke S Nathke. Novel self-association of NH2-terminal regions of the Adenomatous polyposis coli protein regulates APC cluster formation and cell migration. Journal of Cell Science, 2008, 121: 1916-1925. IF 6.290

60. Zhuoyu Li*, Yanfeng Qu, Hanqing Li, Jingming Yuan. Truncations of gelonin lead to a reduction in its cytotoxicity. Toxicology, 2007, 7; 231(2-3): 129-136. IF 3.641

61. Kroboth, K, Newton, I.P, Zumbrunn, J, Zhuoyu, Li, Kita, K, Waterman-Storer, C.M, N?thke, I.S. Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability. Mol. Biol. Cell, 2007,18: 910-918. IF 5.861

62. Martin Hossan; Zhuoyu Li, Yawei Shi, Ulrike Kreilinger, Jorn Butter, Pia D Vogel, Jingming Yuan, John Wise, Wolfgang E. Trommer, Novel immunotoxin: a fusion protein consisting of gelonin and acetylcholine receptor fragment as a potential immunotherapeutic agent for the treatment of Myasthenia gravis. Protein Expression and Purification, 2006, 46: 73-84. IF 1.644

63. Zhuoyu Li, Inke S N?thke. Tumor-associated NH2-terminal fragments are the most stable part of the Adenomatous Polyposis Coli protein and can be regulated by interactions with COOH-terminal domains, Cancer Research, 2005, 65 (12): 5195-5204. IF 9.234

 

已授权发明专利:

1)  冬葵子活性蛋白的制备方法和应用:201410238318.3,排名第一;

2)  一种地木耳抗肿瘤多糖及其制备方法和应用:201410459857.X,排名第一;

3)  一种地皮菜水应激蛋白基因及其重组蛋白的制备和应用,201310291766.5,排名第一;

4)  一种胰蛋白酶抑制剂及其制备方法和应用:201210012186.3,排名第一;

5)  一种谷糠抗肿瘤活性蛋白及其制备方法和应用:201210084106,排名第一;

6)  一种胰蛋白酶抑制剂活性片段衍生物及其制备方法和应用:201110313113.3,排名第一;

7)  一种植物源农药及其生产方法和应用:201010259258.5,排名第二;

8)  力生长因子多肽及其制备方法和用途:201010224435.6,排名第三。

 

Genebank 发表新基因:

2013年发布地皮菜水应激蛋白基因,序列号为KF 003026。

 

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