Li Dong Ph. D
	Professor & Doctoral Supervisor
	Email：Dongli@sxu.edu.cn

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      Master Enrollment Types：Academic and Professional

Master Enrollment Majors：Genetics, Biotechnology and Engineering

Doctoral Enrollment Type：Academic

Doctoral Enrollment Major：Genetics

 

The research group focuses on the immunopathological mechanisms and prevention and control technologies of pathogen - infectious diseases. In the past five years, Professor Dong has presided over projects such as the National Natural Science Foundation for Young Scientists, the General Program of the National Natural Science Foundation, the Key Research and Development Program of Shanxi Province, the General Program of the Shanxi Provincial Department of Science and Technology, and the Scientific Research Project for Returned Overseas Chinese in Shanxi Province. The specific research directions are as follows:

 

1. Identification of Tuberculosis - Susceptible Genes and Molecular Mechanisms

In view of the differences in the incidence of tuberculosis among different populations, this research takes the natural - history cohort of people with different tuberculosis infection status as the research object. High - throughput sequencing and other methods are used to explore tuberculosis - susceptible genes. On the one hand, these genes can be used as biomarkers combined with risk assessment methods to indicate the value of early screening. On the other hand, molecular biology techniques are used to verify the molecular mechanism by which specific susceptible genes affect the formation of tuberculosis.

 

2. Mechanisms of Mycobacterium Tuberculosis - Regulated Immunometabolic Reprogramming in the Development of Tuberculosis

Centered around the complex immunometabolic balance reprogramming process in the development of tuberculosis, from the "pathogen - host cell" molecular interaction interface, this research integrates clinical case specimens, cell models, and animal experiments to analyze the mechanism by which Mycobacterium tuberculosis induces the development of tuberculosis.

 

3. Research on the Immunomodulatory Mechanisms and Key Technologies of Mesenchymal Stem Cells in the Treatment of Refractory Tuberculosis

Based on the host - oriented treatment strategy for tuberculosis, this research utilizes the immunomodulatory properties and stemness potential of mesenchymal stem cells. It multi - dimensionally empowers mesenchymal stem cells, evaluates their effects on regulating innate immune cells and adaptive T - cell immunity during the development of tuberculosis, and explores the key technologies for their application in treatment through in - vivo animal experiments to tap their clinical transformation value.

 

4. Research on the Role of Exosomes - Mediated Immune and Vascular Microenvironments in the Disease Pathogenesis

In view of the latest discovery that exosomes act as "communication messengers" between cells and between cells and the microenvironment, this research takes cells infected with specific pathogens as the source of exosomes. From the perspectives of the immune microenvironment and the vascular microenvironment, it integrates clinical case specimens, cell models, and animal experiments to explore the molecular mechanisms by which exosomes mediate cell signal transduction pathways and affect the occurrence and development of diseases at multiple levels.

Research Graduate Students
PhD Students

Masters Students

Scientific Research Projects Presided over in the Past Five Years

1. National Natural Science Foundation (General Program): Research on the Role of Exosomal HMGB1 in Promoting Cervical Cancer Progression by Regulating the Immune Microenvironment, 2023 - 2026, Presided over, in progress.

2. National Natural Science Foundation (Young Scientists Program): Cohort Study on the Association between Exosomal Cell Adhesion - Related Membrane Proteins and the Risk of Cervical Cancer, 2019 - 2021, Presided over, completed.

3. Central Guiding Local Science and Technology Development Fund Project of the Shanxi Provincial Department of Science and Technology, No. YDZJSX2024D008: Research on the Influence and Mechanism of APOA1 Protein - Regulated Macrophage Immunometabolic Reprogramming on Tuberculosis Pathogenesis, 2024 - 2027, Presided over, in progress.

4. Key Research and Development Program of the Shanxi Provincial Department of Science and Technology: Research on Key Technologies of Mesenchymal Stem Cells for the Treatment of Drug - Resistant Tuberculosis, 2021 - 2024, Presided over, in progress.

5. "Four - Batch" Scientific and Technological Innovation Project of the Shanxi Provincial Health Commission: Research on the Immunoregulatory Role of Mesenchymal Stem Cells in Anti - Drug - Resistant Tuberculosis, 2021 - 2023, Presided over, completed.

6. Research Project for Returned Overseas Chinese in Shanxi Province: Research on the Role and Mechanism of Exosomal miR - 21 in the Development of Cervical Cancer, 2021 - 2022, Presided over, completed.

7. Scientific and Technological Innovation Project of Higher Education Institutions in Shanxi Province: Research on the Role of Exosomal Membrane Proteins in the Progression from HPV Infection to Cervical Cancer and Their Application in Cervical Cancer Screening, 2019 - 2021, Presided over, completed.

8. Shanxi Provincial Natural Science Foundation (General Program): Research on the Role of Exosomal Survivin Protein in the Progression of Cervical Lesions in HPV - Infected Individuals, 2018 - 2020, Presided over, completed.

 

Representative Papers

1.Yating Zhang, Jie Han, Qianwei Yang, Xiaogang Cui, Huiping Duan, Ting Wu, Changxin Wu, Li Xing, Qunqun Liu, Li Dong. miR-1236-3p targets Toll-like receptor 4 to suppress the anti-Mycobacterium tuberculosis activity of macrophage. iScience. 2025. Accepted.

2.Yang Q, Zhou Y, Farooq W, Liu Q, Duan J, Xing L, Wu C, Dong L. The immunomodulatory effects of Mesenchymal stem cells on THP-1-derived macrophages against Mycobacterium tuberculosis H37Ra infection. Tuberculosis (Edinb). 2025, 150:102593.

3.Yang C, Han J, Liu H, He Y, Zhang Z, Liu X, Waqas F, Zhang L, Duan H, He J, Dong L. Storage of plasma-derived exosomes: evaluation of anticoagulant use and preserving temperatures. Platelets. 2024, 35(1): 2337255.

4.Fan X, He W, Zhang Q, Zhang B, Dong L, Li L, Liu X. Evaluation and Prediction Analysis of 3- and 5-Year Relative Survival Rates of Patients with Cervical Cancer: A Model-Based Period Analysis. Cancer Control. 2024,10732748241232324.

5.Dong L, Xing L. Editorial: The biological mechanism and health effect of co-infection with multiple pathogens. Front Cell Infect Microbiol. 2024,14: 1370067.

6.Wu M, Yang Q, Yang C, Han J, Liu H, Qiao L, Duan H, Xing L, Liu Q, Dong L, Wang Q, Zuo L. Characteristics of plasma exosomes in drug-resistant tuberculosis patients. Tuberculosis (Edinb). 2023,141: 102359.

7.贾晨曦, 刘麒苗, 武琛佳, 董丽等. ApoA-I在结核病形成中的潜在作用及机制研究[J]. 中国细胞生物学学报, 2024, 46(06): 1265-1273.

8.Dong L, Nygård M, Støer NC, Klungsøyr O, Hansen BT. Real-world effectiveness of HPV vaccination against cervical neoplasia among birth cohorts ineligible for routine vaccination. Int J Cancer. 2023,153(2): 399-406.

9.康瑾, 葛安, 薛凯凯, 董丽 等. HPV16 E6通过影响外泌体中β-联蛋白和紧密连接蛋白1表达促进宫颈癌细胞增殖、迁移和侵袭 [J]. 中国生物化学与分子生物学报，2023,39(03): 462-469.

10. Dong L, Nygård M, Nathalie CS, Ole K, Hansen BT. Real-world effectiveness of HPV vaccination against cervical neoplasia among birth cohorts ineligible for routine vaccination. Int J Cancer, 2023, 153(2):399-406.

11. Dong L, Nygård M, Hansen BT. Sociodemographic Correlates of Human Papillomavirus Vaccine Uptake: Opportunistic and Catch-Up Vaccination in Norway. Cancers, 2021, 13(3483): 1-13.

12. Yang C, Ma X, Dong L. Low serum calcium and phosphorus and their clinical performance in detecting COVID-19 patients. J Med Virol. 2021,93(3):1639-1651.

13. Ma XX, Ge A, Han J. Meta‑analysis of downregulated E‑cadherin as a diagnostic biomarker for cervical cancer. Archives of Gynecology and Obstetrics,2021,1(13):14-24.

14. Han J, Ning P, Dong L. Association of polymorphisms of innate immunity-related genes and tuberculosis susceptibility in Mongolian population. Human Immunology, 2021,82(4):232-239

15. Zhang SS, Dong L, Wang GM, et al. Progressive liver injury and increased mortality risk in COVID-19 patients: A retrospective cohort study in China. World J Gastroenterol, 2021,27(9): 835-853.

16. Dong L, Zhang L, Hu SY, et al. Risk stratification of HPV 16 DNA methylation combined with E6 oncoprotein in cervical cancer screening: a ten-year prospective cohort study. Clinical Epigenetics,2020,3(1):1-8

17. Yin J, Dong L, Zhao J, et al. Composition and consistence of the bacterial microbiome in upper, middle and lower esophagus before and after Lugol’s iodine staining in the esophagus cancer screening. Scandinavian Journal of Gastroenterology, 2020, 55(12): 1467-1474.

18. Dong L, Li T, Li L, et al. Clustering patterns of type-type combination in multiple genotypes infections of human papillomavirus in cervical adenocarcinoma. Journal of Medical Virology,2019, 91(11):2001-2008.

19. Dong L, Yin J, Zhao J, et al. Microbial Similarity and Preference for Specific Sites in Healthy Oral Cavity and Esophagus. Frontier in Microbiology, 2018, 9:1603.

20. Dong L, Wang M, Zhao XL, et al. Human papillomavirus viral load as a useful tool for non-16/18 high-risk human papillomavirus positive women: a prospective screening cohort study. Gynecologic Oncology, 2018, 148(1):103-110.

21. Dong L, Hu SY, Zhang Q, et al. Risk prediction of cervical cancer and precancers by type-specific human papillomavirus: evidence from a population-based cohort study in China. Cancer Prevention Research, 2017,10(12):745-751.

22. Dong L, Lin CQ, Li L, et al. An evaluation of clinical performance of FTA cards for HPV 16/18 detection using cobas 4800 HPV Test compared to dry swab and liquid medium[J]. Journal of Clinical Virology, 2017, 94(8):67-71.

23. Dong L, Feng RM, Zhang LX, et al. Prospective comparison of hybrid capture 2 and SPF10-LiPA for carcinogenic human papillomavirus detection and risk prediction of cervical cancer: a population-based cohort study in China. Journal of gynecologic oncology, 2017, 28(5): e66.

24. Zhang Q, Dong L, Hu SY, et al. Risk Stratification and Long-term Risk Prediction of E6 Oncoprotein in a Prospective Screening Cohort in China. International Journal of Cancer, 2017, 141(6):1110-1119.