Qiuhong Xiong   Ph.D
	Associate professor   Doctoral Supervisor
	Email: qxiong@sxu.edu.cn

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Research Projects

Autophagy is the major lysosomal route for the turnover of cytoplasmic components. It involves the sequestration and transport of complete regions of the cytoplasm, including both soluble proteins and entire organelles within double-membrane vacuoles, to the lysosomal system for degradation and recycling by lysosomal hydrolases. It is a highly conserved proteolytic mechanism from yeast to man. Impairment of autophagy is thought to underlie the etiology of numerous diseases such as cancer, inflammation, infectious and neurodegenerative diseases. Our group recently focuses on:

1)      Roles of autophagy in human diseases. Currently we are focused on the role of autophagy-related protein WDR45 in beta-propeller protein-associated neurodegeneration (BPAN).

2)      Functions of ATGs in the crosstalk between autophagy and UPS using model organism Dictyostelium discoideum.

Grants

1.         Shanxi Province Science and Technology Cooperation and Exchange Project.

2.         Shanxi Scholarship Council of China.

3.         National Natural Science Foundation of China.

4.         The Central Guidance on Local Science and Technology Development Fund of Shanxi Province.

5.         National Natural Science Foundation of China.

6.         Natural Science Foundation of Shanxi Province, China.

7.         Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province, China.

Team

Master’s students

Publications

1.  Guangxin Chen, Lin Shen, Hong Hu, Yazhi Feng, Da Wen, Yiyao Liu, Huizhe Zhai, Wei Sun, Meifen Wang, Xinghua Lei, Ping Li, Qiuhong Xiong, Changxin Wu. Sulforaphane inhibits oxidative stress and may exert anti-pyroptotic effects by modulating NRF2/NLRP3 signaling pathway in Mycobacterium tuberculosis-infected macrophages. Microorganisms, 2024, 12(6):1191.

2.  Qiuhong Xiong*, Huimin Sun, Yanlin Wang, Qian Xu, Yu Zhang, Mei Xu, Zhonghua Zhao, Ping Li*, Changxin Wu*. Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn. Lipids in Health and Disease, 2024, 23:91.

3. Ping Li*, Yuqian Xi, Yanping Zhang, Abdus Samad, Wenli Lan, Ya Wu, Jiayu Zhao, Guangxin Chen, Changxin Wu, Qiuhong Xiong*. GLA mutations suppress autophagy and stimulate lysosome generation in Fabry disease. Cells. 2024, 13(5):437.

4.  Qiuhong Xiong*, Huimin Sun, Wenxiu Xing, Xin Li, Guangxin Chen, Zhonghua Zhao, Changxin Wu*, Ping Li*. WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism. Free Radical Biology and Medicine. 2023, 201:89-97.

5. Qiuhong Xiong*, Ludwig Eichinger*. Model organisms to study autophagy. Cells. 2023, 12(18):2212.

6.  Guangxin Chen*, Da Wen, Lin Shen, Yazi Feng, Qiuhong Xiong, Ping Li, Zhonghua Zhao*. Cepharanthine exerts antioxidant and anti-inflammatory effects in lipopolysaccharide (LPS)-induced macrophages and DSS-induced colitis mice. Molecules. 2023, 28(16):6070.

7.   Qiuhong Xiong*, Rong Feng, Sarah Fisher, Malte Karow, Maria Stumpf, Susanne Meßling, Leonie Nitz, Stefan Müller, Christoph S Clemen, Ning Song, Ping Li, Changxin Wu, Ludwig Eichinger*. Proteasomes of autophagy-deficient cells exhibit alterations in regulatory proteins and a marked reduction in activity. Cells. 2023, 12(11):1514.

8.  Guangxin Chen*, Ziyue Yang, Da Wen, Ping Li, Qiuhong Xiong, Changxin Wu*. Oridonin inhibits Mycobacterium marinum infection induced oxidative stress in vitro and in vivo. Pathogens. 2023, 12(6):799.

9. Ping Li*, Wenli Lan#, Jiaying Li#, Zhang Y, Qiuhong Xiong, Jinpei Ye, Changxin Wu, Han Xiao*. Identification and functional evaluation of a novel TBX4 mutation underlies small patella syndrome. International journal of molecular sciences. 2022, 23(4):2075.

10. Ping Li*, Yanru Wu, Huizhi Wu, Qiuhong Xiong, Na Zhao, Guangxin Chen, Changxin Wu, Han Xiao*. Functional characterization of FH mutation c.557G>A underlies uterine leiomyomas. International journal of molecular sciences. 2022, 23(3):1452.

11.  Da Wen, Jia Cui, Ping Li, Qiuhong Xiong, Guangxin Chen*, Changxin Wu*. Syndecan-4 assists Mycobacterium tuberculosis entry into lung epithelial cells by regulating the Cdc42, N-WASP, and Arp2/3 signaling pathways. Microbes and Infection, 2022:104931.

12.  Yanping Zhang#, Han Xiao#, Qiuhong Xiong, Changxin Wu*, Ping Li*. Two novel hydroxymethylbilane synthase splicing mutations predispose to acute intermittent porphyria. International journal of molecular sciences. 2021, 22(20):11008. （# co-first author）

13.  Qiuhong Xiong*, Ning Song, Ping Li, Sarah Fischer, Roman Konertz, Prerana Wagle, Gernot Glöckner, Changxin Wu*, Ludwig Eichinger*. RNAseq and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16. BMC Genomics. 2021, 22(1):444.

14.  Na Zhao, Yanling Yang, Ping Li, Qiuhong Xiong, Han Xiao*, Changxin Wu*. Identification of two novel compound heterozygous EIF2AK3 mutations underlying Wolcott-Rallison Syndrome in a Chinese family. Frontiers in Pediatrics. 2021, 9:679646.

15.  Guangxin Chen, Ziyue Yang, Da Wen, Jian Guo, Qiuhong Xiong, Ping Li, Liping Zhao, Junping Wang*, Changxin Wu*, Lina Dong*. Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis. Immunity, Inflammation and Disease. 2021, 9(3):959-970.

16.  Qiuhong Xiong*, Xin Li, Wenjing Li, Guangxin Chen, Han Xiao, Ping Li*, Changxin Wu*. WDR45 mutation impairs the autophagic degradation of transferrin receptor and promotes ferroptosis. Frontiers in Molecular Biosciences. 2021, 8:645831.

17.  Liqing Wang, Qiuhong Xiong, Ping Li, Guangxin Chen, Nayab Tariq, Changxin Wu*. The negative charge of the 343 site is essential for maintaining physiological functions of CXCR4. BMC Molecular and Cell Biology. 2021, 22(1):8.

18.  Yaxin Han, Dongming Wang, Jinli Guo, Qiuhong Xiong, Ping Li, Yongan Zhou, Bin Zhao*. A novel splicing pathogenic variant in COL1A1 causing osteogenesis imperfecta (OI) type I in a Chinese family. Molecular Genetics & Genomic Medicine. 2020, 8(9):e1366.

19. Malte Karow M, Sarah Fisher, Susanne Meßling, Roman Konertz, Jana Riehl, Qiuhong Xiong, Ramesh Rijal, Prerana Wagle, Christoph S Clemen, Ludwig Eichinger*. Functional characterization of the autophagy ATG12~5/16 complex in Dictyostelium discoideum. Cells. 2020, 9(5):1179.

20. Yongan Zhou, Ping Li*, Yanping Zhang, Qiuhong Xiong, Chao Li, Zhonghua Zhao, Yuxian Wang, Han Xiao*. Identification of a novel compound heterozygous IDUA mutation underlies Mucopolysaccharidoses type I in a Chinese pedigree. Molecular Genetics & Genomic Medicine. 2020, 8(1):e1058.

21.  Qiuhong Xiong*, Min Yang, Ping Li, Changxin Wu*. Bacteria exploit autophagy for their own benefit. Infection and Drug Resistance. 2019, 12:3205-3215.

22.  Qiuhong Xiong*, Wenjing Li, Ping Li, Zhonghua Zhao, Changxin Wu*, Han Xiao*. Functional evidence for a de novo mutation in WDR45 leading to BPAN in a Chinese girl. Molecular Genetics & Genomic Medicine. 2019, 7(9):e858.

23. Ping Li*, Lijuan Zhang, Qiuhong Xiong, Zhe Wang, Xiaodong Cui, Yongan Zhou, Yuxian Wang, Han Xiao*, Changxin Wu*. Functional evaluation of a novel GLA causative mutation in Fabry disease. Molecular Genetics & Genomic Medicine. 2019, 7(9):e864.

24. Ping Li*, Lijuan Zhang, Na Zhao, Qiuhong Xiong, Yongan Zhou, Changxin Wu*, Han Xiao*. A novel α-Galactosidase A splicing mutation predisposes to Fabry disease. Frontiers in Genetics. 2019, 10:60.

25. Qiuhong Xiong, Wenjing Li, Ping Li, Min Yang, Changxin Wu*, Ludwig Eichinger*. The role of ATG16 in autophagy and the ubiquitin proteasome system. Cells. 2019, 8(1):2.

26. Qiuhong Xiong, Sarah Fischer, Malte Karow, Rolf Müller, Susanne Meßling, Ludwig Eichinger*. ATG16 mediates the autophagic degradation of the 19S proteasomal subunits PSMD1 and PSMD2. European Journal of Cell Biology. 2018, 97(8):523-532.

27. Qiuhong Xiong, Yi Liu, Yu Xue, Shichao Liu, Jing Wang, Ping Li, Changxin Wu, Yanling Yang*, Han Xiao*. A novel de novo mutation in COL2A1 leading to spondyloephyseal dysplasia congenita in a Chinese family. Human Genome Variation. 2018, 5:17059.

28. Susanne Meβling, Jan Matthias, Qiuhong Xiong, Sarah Fisher, Ludwig Eichinger*. The two Dictyostelium discoideum autophagy 8 proteins have distinct autophagic functions. European Journal of Cell Biology. 2017, 96(4):312-324.

29. Ana Mesquita, Elena Cardenal-Muñoz, Eunice Dominguez, Sandra Muñoz-Braceras, Beatriz Nuñez-Corcuera, Ben A Phillips, Luis C Tábara, Qiuhong Xiong, Roberto Coria, Ludwig Eichinger, Pierre Golstein, Jason S King, Thierry Soldati, Olivier Vincent, Ricardo Escalante*. Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model. Autophagy. 2017, 13(1): 24-40.

30. Qiuhong Xiong Q, Can Ünal, Jan Matthias, Michael Steinert, Ludwig Eichinger*. The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions. Open Biology. 2015, 5(4):150008.

31. Tenghe Ma#, Qiuhong Xiong#, Bao Yuan, Hao Jiang, Yan Gao, Jingbo Xu, Siyuan Liu, Yu Ding*, Guoliang Zhang, Yumin Zhao, Jiabao Zhang*. Luteinizing hormone receptor splicing variants in bovine Leydig cells. Genetics and Molecular Research. 2012, 11(2):1721-30. （# co-first author）

32.  Tenghe Ma, Hao Jiang, Yan Gao, Yumin Zhao, Lisheng Dai, Qiuhong Xiong, Yanli Xu, Zhihui Zhao, Jiabao Zhang*. Microarray analysis of differentially expressed microRNAs in non-regressed and regressed bovine corpus luteum tissue; microRNA-378 may suppress luteal cell apoptosis by targeting the interferon gamma receptor 1 gene. Journal of Applied Genetics. 2011, 52(4):481-6.