|
Qinglai Meng Ph.D |
| Professor & Master Supervisor | |
| Email: qmeng@sxu.edu.cn |
Educational Background and Work Experience
Bachelor's degree in Biotechnology from Northeast Agricultural University. PhD in Microbiology from the Wuhan Institute of Virology, Chinese Academy of Sciences. During the graduate program, I was engaged in research on the immune protection mechanism of lenti-virus vaccines and bio-microanalysis technology. From 2009 to 2017, I worked as a research associate at the Department of Infectious Diseases, Case Western Reserve University, where I conducted research on the immunopathology and immunotherapy of viral hepatitis C (HCV), HIV, and tuberculosis (TB). In 2017, I joined the Biomedical Research Institute of Shanxi University as a high-level talent and was appointed as a core scientist of the Shanxi Province Hundred People Plan Innovation Team in 2020. Currently, I serve as a national committee member of the Physician Association of the Western Returned Scholars Association, a committee member of the Infection and Immunity Branch of the Chinese Society of Immunology, a national committee member of the Biosensor Branch of the Chinese Society of Biomedical Engineering. I am also a reviewer for SCI journals such as Sensors and Actuators B, Microbiology Spectrum, Infectious Microbes & Diseases, and Plos One.
Main research directions
Dr. Meng Qinglai has been engaged in research related to infection and immunology for a long time. Currently, the research group is mainly focused on developing new detection technologies and studying resistance mechanisms for clinically important β-lactamases. Developing rapid, sensitive, and accurate methods for clinical detection and diagnosis is crucial for timely and effective control of infectious diseases, precise treatment, and reducing the occurrence of AMR. The current main research directions include:
1. Developing new methods for rapid detection and monitoring of clinical pathogen resistance and antibiotic blood concentration
2. Investigating the resistance mechanisms of emerging β-lactamases and their mutants
3. Researching new detection technologies for high-sensitivity, high-standardization, and AI integrated detection of pathogens and immunology
Enrollment majors
1. Academic master's degree: Genetics, Microbiology
2. Professional master's degree: Biology and Medicine
Group members
Fundings
Shanxi Province international cooperation projects, Shanxi Province College of Science and Technology achievements transformation and cultivation projects, Shanxi Province Medical Key Research Project, Shanxi Province overseas returnees science and technology activities preferential funding projects; as a Co-PI participated in two national key research and development projects and national infectious disease major projects; as a co-PI to participate in many national and provincial projects.
Selected Publications
2. Chenchen Song, Xuan Sun, Yao Wang, Leif Bülow, Michael Mecklenburg, Changxin Wu, Qinglai Meng*, Bin Xie2*. Activity fingerprinting of AMR β-lactamase towards a fast and accurate diagnosis. Front Cell Infect Microbiol. 2023. 13:1222156. (as the co-corresponding author)
3. Xiangyu Yao, Zhichao Zhang, Qingmin Mei, Shenwei Li, Li Xing, Yali Long, Demei Zhang, Jing Wang, Xiedong Wang, Bin Xie, Bo Yang, Yong Gao, Changxin Wu1, Qinglai Meng. A highly sensitive bead-based flow cytometric competitive binding assay to detect SARS-CoV-2 neutralizing antibody activity. Frontiers in Immunology. 2022, 13:1041860. (as the corresponding author)
4. Qinglai Meng#,*, Yao Wang#, Yali Long#, Aiping Yue, Michael Mecklenburg, Shuaiyan Tian, Yujia Fu, Xiangyu Yao, Jianyi Liu, Dewei Song*, Changxin Wu* and Bin Xie*. Rapid Detection of Multiple Classes of β-Lactam Antibiotics in Blood Using an NDM-1 Biosensing Assay. Antibiotics. 2021, 10(9), 1110. (as the first and the corresponding author)
5. Qinglai Meng*, Yujia Fu, Shenzhi Li, Yujuan Yan, Danli Duan, Donald D Anthony, Yueping Zhu, Xuehua Wu, Feng Qian* and Changxin Wu*. Rapid, sensitive and cost-effective determination of immune checkpoint inhibitor activity using a magnetic bead-based binding assay. Journal of Immunological Methods. November 498 (2021), 113134. (as the first and the corresponding author)
6. Qinglai Meng#,*, Shichao Liu#, Jinhua Meng#, Jiao Feng, Michael Mecklenburg, Lei Zhu, Lifang Zhou, Leif Bülow, Jianyi Liu, Dewei Song*, Changxin Wu*, Bin Xie*. Rapid personalized AMR diagnostics using two-dimensional antibiotic resistance profiling strategy employing a thermometric NDM-1 biosensor. Biosensors and Bioelectronics. 193 (2021) 113526. (as the first and the corresponding author)
8. Josefin Adlerberth#, Qinglai Meng#, Michael Mecklenburg，Zengmin Tian*, Yikai Zhou, Leif Bülow, Bin Xie*. Journal of Thermal Analysis and Calorimetry. Thermometric analysis of blood metabolites in ICU patients. 2020. 140:763–771. (as the co-first author)
9、Qinglai Meng#, Asifa K#. Zaidi, John Sedy, Armand Bensussan, Daniel L*. Soluble Fc-Disabled Herpes Virus Entry Mediator Augments Activation and Cytotoxicity of NK Cells by Promoting Cross-Talk between NK Cells and Monocytes. The Journal of Immunology, 2019, 202(7): 2057-2068
10、Qinglai Meng*, Ismail Sayin, David H. Canaday, Harriet Mayanja-Kizza, Joy Baseke, Zahra Toossi*. Immune Activation at Sites of HIV/TB Co-infection contributes to the pathogenesis of HIV-1 disease. Plos One. 2016 Nov 21; 11 (11): e0166954
11、Qinglai Meng, David H. Canaday, David J. McDonald, Harriet Mayanja-Kizza, Joy Baseke, Zahra Toossi*. Productive HIV-1 infection is enriched in CD4-CD8- double negative (DN) T cells at pleural sites of dual HIV/TB infection. Archives of Virology. 2016 Jan; 161 (1):181-187. (as the first and the corresponding author)
12、Qinglai Meng, M R Sandhya Rani, Julia M Sugalski, Chelsey J. Judge, Sarah Phat, Ronald E Blanton, Benigno Rodriguez and Donald D. Anthony*. Natural Cytotoxicity Receptor-Dependent Natural Killer Cytolytic Activity Directed at Hepatitis C Virus (HCV) Is Associated With Liver Inflammation, African American Race, IL28B Genotype, and Response to Pegylated Interferon/Ribavirin Therapy in Chronic HCV Infection. J Infect Dis. 2014. 290 (10): 1591-1601
13、Sara J Conry#, Qinglai Meng#, Gareth Hardy, Nicole L Yonkers, Julia M Sugalski, Amy Hirsch, Perica Davitkov, Anita Compan, Yngve Falck-Ytter, Ronald E. Blanton, Benigno Rodriguez, Clifford V Harding and Donald D. Anthony*. Genetically associated CD16+56- NK-cell IFN-aR expression regulates signaling and is implicated in IFN-a-induced HCV decline. J Infect Dis. 2012. 205(7):1131-41. (as the co-first author)
14、Qinglai Meng# Yuezhi Lin#, Jian Ma, Yan Ma, Liping Zhao, Shenwei Li, Kai Yang, Jianhua Zhou, Rongxian Shen, Xiaoyan Zhang* and Yiming Shao*. A pilot study comparing the development of EIAV Env-specific antibodies induced by DNA/recombinant vaccinia-vectored vaccines and an attenuated Chinese EIAV vaccine. Viral Immunol. 2012. 25(6):477-84
15、Meng Qinglai#, Lin Y#, Ma J, Ma Y, Zhao L, Li S, Liang H, Zhou J, Shen R, Zhang X* and Shao Y*. 2011. A pilot study on an attenuated Chinese EIAV vaccine inducing broadly neutralizing antibodies. Arch Virol. 2011. 156(8):1455-62
16. Meng Q, Li S, Liu L, Xu J, Liu Y, Zhang Y, Zhang X* and Shao Y*. Truncation of cytoplasmic tail of EIAV Env increases the pathogenic necrosis. Virus Research. 2008. 133(2):201-210.
17. Meng Q, Mecklenburg M, Danielsson B and Xie B*. Development of a tRNA-Synthetase Microarray for Protein Analysis. Sensors and Materials. 2004. Vol 16. No.8 401-412
Authorized Patents
Qinglai Meng, Shuaiyan Tian, Changxin Wu, Xiedong Wang. A novel method for detecting pathogen antibodies and its application in detecting new coronavirus antibodies，Authorized at May/27/2024，China Invention Patent, Patent No. ZL 2021 1 1668292.2
Qinglai Meng, Xiangyu Yao, Changxin Wu, Yujia Fu. Novel Coronavirus Neutralizing Antibody Magnetic Bead Fluorescence Detection Kit and Its Detection Method，Authorized at April/13/2023，China Invention Patent， Patent No. ZL202111022211.1
Qinglai Meng, Yujia Fu, Shenzhi Li, Changxin Wu. Magnetic bead assay for evaluating immune checkpoint molecule blocking antibody blocking activity，Authorized at March/30/2021, China Invention Patent，Patent No. ZL2020 1 0005802.7
Bin Xie, Qinglai Meng, Weihong Xie. “Method of a tRNA-Synthetase Microarray Preparation”. Authorized at Jan/4/2006, China patent, ZL02139106.8
Research Awards
1. 2021 Shanxi Province Science and Technology Worker Double Innovation Competition, Gold Award, "Immune checkpoint inhibitor blocking activity magnetic bead fluorescence detection method and PD-1 inhibitor activity detection kit", Meng Qinglai (1/1)
2. 2022 "Star of Innovation" China Experimental Medicine Excellent Paper Award, "Rapid personalized AMR diagnostics using two-dimensional antibiotic resistance profiling strategy employing a thermometric NDM-1 biosensor". Awardee: Meng Qinglai
3. Infectious Microbes & Diseases journal 2019-2023 Excellent Reviewer Award, 2024, Awardee: Meng Qinglai
Education Awards
1. The 8th National University Student Life Science Competition (Innovation and Entrepreneurship Category), won the Third Prize for Instructor, with the project "Precise Detection Tool - High-Cost Performance Functional Antibody Flow Cytometry Detection Technology and Detection Kit". Served as the first instructor.
2. The 5th China University Student 5-minute Scientific Research (English) Speech Contest, research student Song Chenchen from the research group won the Third Prize. Awarded as an Excellent Instructor and the first instructor.
3. The 8th "Internet +" University Student Innovation and Entrepreneurship Competition in Shanxi Province, won the Silver Prize, with the project "Precise Anti-epidemic Tool-High Sensitivity New Coronavirus Neutralizing Antibody Detection Kit". Research students Yan Xiayu, Song Chenchen, and Wang Yao from the research group ranked first, second, and third respectively among the winners. Awarded as an Excellent Instructor and the first instructor.
4. The 7th "Internet +" University Student Innovation and Entrepreneurship Competition in Shanxi Province, won the Copper Prize, with the project "Magnetic Bead Evaluation of Immune Checkpoint Blocking Antibody Activity Detection Kit". Research students Yan Xiayu and Wang Yao from the research group ranked first and second respectively among the winners. Awarded as an Excellent Instructor and the first instructor.
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