Changxin Wu   Ph.D
	Professor Doctoral Supervisor
	Email: cxw20@sxu.edu.cn Tel：+86 351 7018958

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Administrative Positions

Head	Head of the Institutes of Biomedical Sciences,   Shanxi University, China
Director	Academic Director of the Institutes of Biomedical   Sciences, Shanxi University, China

General Information

Professor Changxin WU primarily engages in fundamental research on infection and immunity as well as the genetics of human diseases, focusing on the pathological mechanisms of regionally significant diseases and the development of novel intervention technologies. Before and after returning to China, he has led and participated in various projects, including grants sponsored by Nature Science Foundation, China, the National 973 Program, the National Support Plan, the National Key Technology R&D Program, Wellcome Trust, the UK Biotechnology and Biological Sciences Research Council, and major projects under the EU Seventh Framework Program. His significant scientific and academic achievements in the fields of infection and immunity have been published in journals such as Science, Nature Genetics, PNAS, Molecular Cell, Cell Death &   Disease, Biosensors & Bioelectronics, Stem Cell Research & Therapy, Frontiers in Immunology, and Clinical Immunology etc. He has been honored awards from home county and international organizations, such as the Wellcome Trust International Young Career Scientist Award and is a lifetime honorary member of the Cambridge University Overseas Scholarship Committee.

After nearly twenty years of study and work at the University of Cambridge, he accepted an invitation from Shanxi University. Supported by talent programs such as the Shanxi Provincial High-Level Overseas Talent Program, the Shanxi Provincial High-Level Talent Innovation Team, and the Shanxi Provincial "San Jin Elite" Support Program. In 2018, he officially joined Shanxi University to establish the Institutes of Biomedical Sciences, acting as the Director of the Institute and Chief Scientist of the team focused on the pathological mechanisms of significant human diseases and novel intervention technologies. Currently, he serves as a distinguished expert in Shanxi Province, a strategic scientist in Shanxi Province, and Chief Scientist of the National and Local University "Pathological Mechanisms and New Intervention Technologies of Regionally Significant Diseases" Intelligence Base, as well as a council member and executive council member of several local and national academic organizations in fields of life sciences and medicine.

Research Fields

Professor Changxin Wu heading a team consisting different groups focuses on three main fields of research: infection and immunity, rare diseases, and stem cell and its technology.

Infection and Immunity

The team focuses on the pathological mechanisms of tuberculosis (TB) and new intervention technologies, exploring the interactions between tuberculosis pathogens (Mycobacterium tuberculosis, Mtb) and host proteins that contribute to the pathology and progression of TB. They also investigate the molecular and cellular biology mechanisms of the host's immune response and clearance against Mtb. Using natural hosts as model organisms, the team develops host-directed strategies to prevent and treat TB, particularly drug-resistant TB and difficult-to-treat TB. Additionally, they are engaged in developing new diagnostic and detection technologies for other infectious diseases. The principal investigators in this field include Professor Guijun Shang, Professor Li Xing, Professor Li Dong, Professor Qinglai Meng, Associate Professor Jianguo Li, Associate Professor Jiao Feng, Associate Professor Guangxin Chen, Dr. Xiaogang Cui, Dr. Caiting Yang, Dr. Yue Liu, Dr. Zhiqiang Yang, Dr. Yina An, and Dr. Peipei Cao.

Pathological Mechanisms and New Intervention Technologies for Rare Diseases

The groups of my team focus on the pathological mechanisms and new intervention technologies for regionally significant rare diseases, particularly neurological and metabolic rare diseases. They conduct in-depth research by establishment of mouse and zebrafish models to study the molecular and cellular biological mechanisms underlying the rare diseases caused by gene defects. They also attempt to develop new intervention technologies for gene therapy of rare diseases using gene editing technologies and small nucleic acid molecules. The principal investigators in this fields include Professor Zhonghua Zhao, Associate Professor Qiuhong Xiong, Associate Professor Ping Li, and Dr. Ting Liu.

Stem Cell differentiation and Stem Cell Technology

The groups of my team in this field focus on the molecular and cellular biological mechanisms of stem cell differentiation and new intervention technologies in the context of infectious diseases and rare diseases. Particularly, the research investigates the early differentiation mechanisms of embryonic stem cells and the development of new therapeutic techniques using pluripotent stem cells for drug-resistant TB, neurodegenerative diseases, and metabolic rare diseases. The team also conducts preliminary foundational research on the mechanisms of stemness of tumor stem cell and the effects of bioactive small molecules on stemness of tumor stem cell. The principal investigators in this area include Professor Mingze Yao, Professor Li Dong, Associate Professor Lichao Zhang, and Dr. Xiaoqin La.

The team undertakes a series of national major research and development projects, National Natural Science Foundation projects, Shanxi Province overseas high-level talent introduction innovation projects, Shanxi Province overseas high-level talent introduction innovation team projects, key research and development projects in Shanxi Province, and other national and provincial special projects.

The team supervise and train doctoral and master degrees of graduates, while also train professional master degree graduates in bioengineering at Shanxi University.

Research Graduate Students

PhD Students：

Master's Students：

Significant Publications

1．Liu, S.; Yang, B.; Hou, Y.; Cui, K.; Yang, X.; Li, X.; Chen, L.; Liu, S.; Zhang, Z.; Jia, Y.; Xie, Y.; Xue, Y.; Li, X.; Yan, B.; Wu, C.; Deng, W.; Qi, J.; Lu, D.; Gao, G. F.; Wang, P.; Shang, G., The mechanism of STING autoinhibition and activation. Mol Cell 2023, 83 (9), 1502-1518.e10.

2．Yang, B.; Jia, Y.; Meng, Y.; Xue, Y.; Liu, K.; Li, Y.; Liu, S.; Li, X.; Cui, K.; Shang, L.; Cheng, T.; Zhang, Z.; Hou, Y.; Yang, X.; Yan, H.; Duan, L.; Tong, Z.; Wu, C.; Liu, Z.; Gao, S.; Zhuo, S.; Huang, W.; Gao, G. F.; Qi, J.; Shang, G., SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry. Proc Natl Acad Sci U S A 2022, 119 (4).

3．Yaigoub, H.; Fath, N.; Tirichen, H.; Wu, C.; Li, R.; Li, Y., Bidirectional crosstalk between dysbiotic gut microbiota and systemic lupus erythematosus: What is new in therapeutic approaches? Clin Immunol 2022, 244, 109109.

4．Wen, D.; Cui, J.; Li, P.; Xiong, Q.; Chen, G.; Wu, C., Syndecan-4 assists Mycobacterium tuberculosis entry into lung epithelial cells by regulating the Cdc42, N-WASP, and Arp2/3 signaling pathways. Microbes Infect 2022, 24 (4), 104931.

5．Yang, C.; Ma, X.; Wu, J.; Han, J.; Zheng, Z.; Duan, H.; Liu, Q.; Wu, C.; Dong, Y.; Dong, L., Low serum calcium and phosphorus and their clinical performance in detecting COVID-19 patients. J Med Virol 2021, 93 (3), 1639-1651.

6．Li, J.; Li, Z.; Cui, X.; Wu, C., Bayesian phylodynamic inference on the temporal evolution and global transmission of SARS-CoV-2. J Infect 2020, 81 (2), 318-356.

7．Cuchet-Lourenço, D.; Eletto, D.; Wu, C.; Plagnol, V.; Papapietro, O.; Curtis, J.; Ceron-Gutierrez, L.; Bacon, C. M.; Hackett, S.; Alsaleem, B.; Maes, M.; Gaspar, M.; Alisaac, A.; Goss, E.; AlIdrissi, E.; Siegmund, D.; Wajant, H.; Kumararatne, D.; AlZahrani, M. S.; Arkwright, P. D.; Abinun, M.; Doffinger, R.; Nejentsev, S., Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation. Science 2018, 361 (6404), 810-813.

8．Curtis, J.; Luo, Y.; Zenner, H. L.; Cuchet-Lourenço, D.; Wu, C.; Lo, K.; Maes, M.; Alisaac, A.; Stebbings, E.; Liu, J. Z.; Kopanitsa, L.; Ignatyeva, O.; Balabanova, Y.; Nikolayevskyy, V.; Baessmann, I.; Thye, T.; Meyer, C. G.; Nürnberg, P.; Horstmann, R. D.; Drobniewski, F.; Plagnol, V.; Barrett, J. C.; Nejentsev, S., Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration. Nat Genet 2015, 47 (5), 523-527.

9．Yang, J.; Li, X.; Al-Lamki, R. S.; Wu, C.; Weiss, A.; Berk, J.;  Schermuly, R. T.; Morrell, N. W., Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension. Arterioscler Thromb Vasc Biol 2013, 33 (1), 34-42.

10．Angulo, I.; Vadas, O.; Garçon, F.; Banham-Hall, E.; Plagnol, V.; Leahy, T. R.; Baxendale, H.; Coulter, T.; Curtis, J.; Wu, C.; Blake-Palmer, K.; Perisic, O.; Smyth, D.; Maes, M.; Fiddler, C.; Juss, J.; Cilliers, D.; Markelj, G.; Chandra, A.; Farmer, G.; Kielkowska, A.; Clark, J.; Kracker, S.; Debré, M.; Picard, C.; Pellier, I.; Jabado, N.; Morris, J. A.; Barcenas-Morales, G.; Fischer, A.; Stephens, L.; Hawkins, P.; Barrett, J. C.; Abinun, M.; Clatworthy, M.; Durandy, A.; Doffinger, R.; Chilvers, E. R.; Cant, A. J.; Kumararatne, D.; Okkenhaug, K.; Williams, R. L.; Condliffe, A.; Nejentsev, S., Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Science 2013, 342 (6160), 866-71.

11．Goodall, J. C^#.; Wu, C^#.; Zhang, Y.; McNeill, L.; Ellis, L.; Saudek, V.; Gaston, J. S., Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Proc Natl Acad Sci U S A 2010, 107 (41), 17698-703.

Publications

1．Zhang, M.; Wu, C.; Lu, D.; Wang, X.; Shang, G. cGAS-STING: mechanisms and therapeutic opportunities. Science China. Life sciences 2025.

2．Feng, J.; Wu, C.; Zhou, D.; Hu, L.; Mu, K.; Yin, Z. Insights into incompatible plasmids in multidrug-resistant Raoultella superbugs. BMC microbiology2025, 25(1), 55.

3．Zhao, N.; Xiong, Q.; Li, P.; Chen, G.; Xiao, H.; Wu, C. TSC complex decrease the expression of mTOR by regulated miR-199b-3p. Scientific reports2025, 15(1), 1892.

4．La, X.; Zhang, Z.; Liang, J.; Li, H.; Pang, Y.; He, X.; Kang, Y.; Wu, C.; Li, Z. Isolation and purification of flavonoids from quinoa whole grain and its inhibitory effect on lipid accumulation in nonalcoholic fatty liver disease by inhibiting the expression of CD36 and FASN. Journal of the science of food and agriculture2025, 105(2), 1330–1342.

5．Cui, X.; Zhang, F.; Meng, H.; Yuan, T.; Li, M.; Yuan, D.; Fan, X.; Jia, X.; Wang, Q.; Xing, L.;Wu, C. Transport of miR-766-3p to A549 cells by plasma-derived exosomes and its effect on intracellular survival of Mycobacterium tuberculosis by regulating NRAMP1 expression in A549 cells. Microbiological research2025, 290, 127943.

6．Ma, D.; Yao, H.; Liu, Y.; Gong, W.; Zhao, Y.; Wang, R.; Wu, C.; Wang, W.; Wang, H. The reduced interaction between SufS and SufU in Mycoplasma penetrans results in diminished sulfotransferase activity. International journal of biological macromolecules2025, 284(Pt 2), 138181.

7．Yang, Q.; Zhou, Y.; Farooq, W.; Liu, Q.; Duan, J.; Xing, L.; Wu, C.; Dong, L. The immunomodulatory effects of Mesenchymal stem cells on THP-1-derived macrophages against Mycobacterium tuberculosis H37Ra infection. Tuberculosis (Edinburgh, Scotland)2025, 150, 102593.

8．Li, P.; Wu, Y.; Deng, Z.; Samad, A.; Xi, Y.; Song, J.; Zhang, Y.; Li, J.; Zhou, Y. A.; Xiong, Q.; Wu, C. Two novel SH3TC2 mutations predispose to Charcot-Marie-Tooth disease type 4C by mistargeting away from TFRC. Cellular signalling2025, 130, 111669.

9．Li, P.; Xi, Y.; Zhang, Y.; Samad, A.; Lan, W.; Wu, Y.; Zhao, J.; Chen, G.; Wu, C.; Xiong, Q. GLA Mutations Suppress Autophagy and Stimulate Lysosome Generation in Fabry Disease. Cells2024, 13(5), 437.

10．Yang, C.; Wang, H.; Shao, M.; Chu, F.; He, Y.; Chen, X.; Fan, J.; Chen, J.; Cai, Q.; Wu, C. Brain-Type Glycogen Phosphorylase (PYGB) in the Pathologies of Diseases: A Systematic Review. Cells2024, 13(3), 289.

11．Xiong, Q.; Sun, H.; Wang, Y.; Xu, Q.; Zhang, Y.; Xu, M.; Zhao, Z.; Li, P.; Wu, C. Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn. Lipids in health and disease2024, 23(1), 91.

12．Chen, G.; Shen, L.; Hu, H.; Feng, Y.; Wen, D.; Liu, Y.; Zhai, H.; Sun, W.; Wang, M.; Lei, X.; Li, P.; Xiong, Q.; Wu, C. Sulforaphane Inhibits Oxidative Stress and May Exert Anti-Pyroptotic Effects by Modulating NRF2/NLRP3 Signaling Pathway in Mycobacterium tuberculosis-Infected Macrophages. Microorganisms2024, 12(6), 1191.

13．Wang, P. H.; Wang, Y.; Guo, Y. Y.; Ma, Z. H.; Wu, C.; Xing, L. Ibuprofen modulates macrophage polarization by downregulating poly (ADP-ribose) polymerase 1. International immunopharmacology2024, 143(Pt 3), 113502.

14．Han, J.; Kang, X.; Su, Y.; Wang, J.; Cui, X.; Bian, Y.; Wu, C. Plasma exosomes from patients with coronary artery disease promote atherosclerosis via impairing vascular endothelial junctions. Scientific reports2024, 14(1), 29813.

15．Li, J.; Cheng, R.; Bian, Z.; Niu, J.; Xia, J.; Mao, G.; Liu, H.; Wu, C.; Hao, C. Development of multiplex allele-specific RT-qPCR assays for differentiation of SARS-CoV-2 Omicron subvariants. Applied microbiology and biotechnology2024, 108(1), 35.

16．Cui, X.; Meng, H.; Li, M.; Chen, X.; Yuan, D.; Wu, C. Exosomal Small RNA Sequencing Profiles in Plasma from Subjects with Latent Mycobacterium tuberculosis Infection. Microorganisms2024, 12(7), 1417.

17．La, X.; Zhang, Z.; Dong, C.; Li, H.; He, X.; Kang, Y.; Wu, C.; Li, Z.. Isorhamnetin in Quinoa Whole-Grain Flavonoids Intervenes in Non-Alcoholic Fatty Liver Disease by Modulating Bile Acid Metabolism through Regulation of FXR Expression. Foods (Basel, Switzerland)2024, 13(19), 3076.

18．Meng, C.; Chen, G.; Liu, Y.; Wen, D.; Cui, J.; Dong, L.; Yang, Z.; Meng, H.; Gao, Y.; Feng, J.; Cui, X.; Wu, C. miR-4687-5p Affects Intracellular Survival of Mycobacterium tuberculosis through Its Regulation of NRAMP1 Expression in A549 Cells. Microorganisms2024, 12(1), 227.

19．Nie, R.; Zhang, W.; Tian, H.; Li, J.; Ling, Y.; Zhang, B.; Zhang, H.; Wu, C. Proteo-transcriptomic profiles reveal key regulatory pathways and functions of LDHA in the ovulation of domestic chickens (Gallus gallus). Journal of animal science and biotechnology2024, 15(1), 68.

20．Nie, R.; Zhang, W.; Tian, H.; Li, J.; Ling, Y.; Zhang, B.; Zhang, H.; Wu, C. Regulation of Follicular Development in Chickens: WIF1 Modulates Granulosa Cell Proliferation and Progesterone Synthesis via Wnt/β-Catenin Signaling Pathway. International journal of molecular sciences2024, 25(3), 1788.

21．La, X.; He, X.; Liang, J.; Zhang, Z.; Li, H.; Liu, Y.; Liu, T.; Li, Z.; Wu, C. Gastroprotective Effect of Isoferulic Acid Derived from Foxtail Millet Bran against Ethanol-Induced Gastric Mucosal Injury by Enhancing GALNT2 Enzyme Activity. Nutrients2024, 16(13), 2148. Isolation and purification of flavonoids from quinoa whole grain and its inhibitory effect on lipid accumulation in nonalcoholic fatty liver disease by inhibiting the expression of CD36 and FASN. Journal of the science of food and agriculture2025, 105(2), 1330–1342.

22．Cui, X.; Zhang, F.; Meng, H.; Yuan, T.; Li, M.; Yuan, D.; Fan, X.; Jia, X.; Wang, Q.; Xing, L.; Wu, C. Transport of miR-766-3p to A549 cells by plasma-derived exosomes and its effect on intracellular survival of Mycobacterium tuberculosis by regulating NRAMP1 expression in A549 cells. Microbiological research2025, 290, 127943.

23．Ma, D.; Yao, H.; Liu, Y.; Gong, W.; Zhao, Y.; Wang, R.; Wu, C.; Wang, W.; Wang, H.The reduced interaction between SufS and SufU in Mycoplasma penetrans results in diminished sulfotransferase activity. International journal of biological macromolecules2025, 284(Pt 2), 138181.

24．Tufail, M.; Wu, C.; Hussain, M. S. Dietary, addictive and habitual factors, and risk of colorectal cancer. Nutrition (Burbank, Los Angeles County, Calif.)2024, 120, 112334.

25．Wen, D.; Meng, C.; Feng, Y.; Shen, L.; Liu, Y.; Sun, W.; Chen, G.; Wu, C. Syringaldehyde Exhibits Antibacterial and Antioxidant Activities against Mycobacterium marinum Infection. Microorganisms2024, 12(2), 348.

26．Zhang, J.; Xu, W.; Xu, D.; Wu, C.; Xing, L. Diagnosis of a cystic lymphocyte-rich thymoma in a young cat. Veterinary research forum : an international quarterly journal2024, 15(8), 439–443.

27．Chang, Y.; Wu, S.; Li, J.; Bao, H.; Wu, C. Identification of Candidate Genes for Red-Eyed (Albinism) Domestic Guppies Using Genomic and Transcriptomic Analyses. International journal of molecular sciences2024, 25(4), 2175.

28．Chen, L.; Jin, J.; Shao, K.; Xu, Z.; Lv, L.; Wu, C.; Wang, Y. Mixture toxic mechanism of phoxim and prochloraz in the hook snout carp Opsariichthysbidens. Chemosphere2024, 364, 143217.

29．Yang, Q.; Zhou, Y.; Farooq, W.; Liu, Q.; Duan, J.; Xing, L.; Wu, C.; Dong, L. The immunomodulatory effects of Mesenchymal stem cells on THP-1-derived macrophages against Mycobacterium tuberculosis H37Ra infection. Tuberculosis (Edinburgh, Scotland)2025, 150, 102593.

30．Meng, Q.; Wang, Y.; Long, Y.; Wang, Q.; Gao, Y.; Tian, J.; Wu, C.; Xie, B. The New Delhi metallo-β-lactamase-1 biosensor rapidly and accurately detected antibiotic plasma concentrations in cefuroxime-treated patients. International journal of antimicrobial agents2024, 64(2), 107229.

31．Bahoussi, A. N.; Shah, P. T.; Liu, Y.; Guo, Y. Y.; Bu, H.; Wu, C.; & Xing, L. (2024). Evolutionary History and Genetic Variation of Zika Virus: Connection Between Thailand Zika Viruses and Global Outbreaks Strains. Vector borne and zoonotic diseases (Larchmont, N.Y.)2024, 24(2), 122–128.

32．Hussain, B.; Wu, C. Evolutionary and Phylogenetic Dynamics of SARS-CoV-2 Variants: A Genetic Comparative Study of Taiyuan and Wuhan Cities of China. Viruses2024, 16(6), 907.

33．Zhang, L. C.; Liu, Y. N.; La, X. Q.; Li, S. T.; Wen, L. N.; Liu, T.; Li, H. Q.; Li, A. P.; Wu, H.; Wu, C. X.; Li, Z. Y.; The bound polyphenols of foxtail millet (Setaria italica) inner shell inhibit breast cancer by promoting lipid accumulation-induced autophagic death. Food Chem Toxicol 2023, 177, 113855

34．Xiong, Q.; Sun, H.; Xing, W.; Li, X.; Chen, G.; Zhao, Z.; Wu, C.; Li, P.; WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism. Free Radic Biol Med 2023, 201, 89-97.

35．Wang, P. H.; Nawal Bahoussi, A.; Tariq Shah, P.; Guo, Y. Y.; Wu, C.; Xing, L.; Genetic comparison of transmissible gastroenteritis coronaviruses. Front Vet Sci 2023, 10, 1146648.

36．Tufail, M.; Wu, C.; Wnt3a is a promising target in colorectal cancer. Med Oncol 2023, 40 (3), 86.

37．Tufail, M.; Wu, C.; SRPKs: a promising therapeutic target in cancer. Clin Exp Med 2023.

38．Tufail, M.; Wu, C.; Exploring the Burden of Cancer in Pakistan: An Analysis of 2019 Data. J Epidemiol Glob Health 2023.

39．Tian, J.; Zhang, L.; La, X.; Fan, X.; Li, A.; Wu, C.; An, Y.; Yan, S.; Dong, X.; Wu, H.; Li, Z.; Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism. Cell Signal 2023, 108, 110719.

40．Shah, P. T.; Wang, J.; Liu, Y.; Hussain, B.; Ma, Z. H.; Wu, C.; Xing, L.; The phylogenetic and phylogeographic landscape of the beak and feather disease virus, 1996-2022. Infect Genet Evol 2023, 112, 105442.

41．Shah, P. T.; Bahoussi, A. N.; Yang, C.; Yao, G.; Dong, L.; Wu, C.; Xing, L.; Genetic Characteristics and Phylogeographic Dynamics of Lagoviruses, 1988-2021. Viruses 2023, 15 (4).

42．Shah, P. T.; Bahoussi, A. N.; Cui, X.; Shabir, S.; Wu, C.; Xing, L.; Genetic diversity, distribution, and evolution of chicken anemia virus: A comparative genomic and phylogenetic analysis. Front Microbiol 2023, 14, 1145225.

43．Ma, Z. H.; Nawal Bahoussi, A.; Tariq Shah, P.; Guo, Y. Y.; Dong, L.; Wu, C.; Xing, L.; Phylogeographic dynamics and molecular characteristics of Enterovirus 71 in China. Front Microbiol 2023, 14, 1182382.

44．Liu, Y.; Zhu, D.; Liu, J.; Sun, X.; Gao, F.; Duan, H.; Dong, L.; Wang, X.; Wu, C.; Pediococcus pentosaceus PR-1 modulates high-fat-died-induced alterations in gut microbiota, inflammation, and lipid metabolism in zebrafish. Front Nutr 2023, 10, 1087703.

45．Liu, S.; Yang, B.; Hou, Y.; Cui, K.; Yang, X.; Li, X.; Chen, L.; Liu, S.; Zhang, Z.; Jia, Y.; Xie, Y.; Xue, Y.; Li, X.; Yan, B.; Wu, C.; Deng, W.; Qi, J.; Lu, D.; Gao, G. F.; Wang, P.; Shang, G.; The mechanism of STING autoinhibition and activation. Mol Cell 2023, 83 (9), 1502-1518.e10.

46．Han, J.; Cui, X.; Yuan, T.; Yang, Z.; Liu, Y.; Ren, Y.; Wu, C.; Bian, Y.; Plasma-derived exosomal let-7c-5p, miR-335-3p, and miR-652-3p as potential diagnostic biomarkers for stable coronary artery disease. Front Physiol 2023, 14, 1161612.

47．Feng, J.; Li, F.; Sun, L.; Dong, L.; Gao, L.; Wang, H.; Yan, L.; Wu, C.; Characterization and genome analysis of phage vB_KpnS_SXFY507 against Klebsiella pneumoniae and efficacy assessment in Galleria mellonella larvae. Front Microbiol 2023, 14, 1081715.

48．Fan, X.; Zhang, L.; La, X.; Tian, J.; Israr, G.; Li, A.; Wu, C.; An, Y.; Li, S.; Dong, X.; Li, Z.; Salvianolic acid A attenuates inflammation-mediated atherosclerosis by suppressing GRP78 secretion of endothelial cells. J Ethnopharmacol 2023, 308, 116219.

49．Bahoussi, A. N.; Shah, P. T.; Zhao, J. Q.; Wang, P. H.; Guo, Y. Y.; Wu, C.; Xing, L.; Multiple potential recombination events among Newcastle disease virus genomes in China between 1946 and 2020. Front Vet Sci 2023, 10, 1136855.

50．Bahoussi, A. N.; Shah, P. T.; Guo, Y. Y.; Liu, Y.; Wu, C.; Xing, L.; Evolutionary adaptation of bovine coronavirus (BCoV): Screening of natural recombinations across the complete genomes. J Basic Microbiol 2023, 63 (5), 519-529.

51．Zhang, Y.; Wang, X.; Li, Z.; Zhang, J.; Wang, Y.; Wu, C.; Chen, C.; Li, J.; Zhang, H.; Brucella melitensis outer membrane protein 25 interacts with ferritin heavy polypeptide 1 in human trophoblast cells. Mol Med Rep 2022, 26 (1).

52．Zhang, H.; Huang, Z.; Lv, L.; Xin, Y.; Wang, Q.; Li, F.; Dong, L.; Wu, C.; Ingham, P. W.; Zhao, Z.; A transgenic zebrafish for in vivo visualization of cilia. Open Biol 2022, 12 (8), 220104.

53．Yao, X.; Zhang, Z.; Mei, Q.; Li, S.; Xing, L.; Long, Y.; Zhang, D.; Wang, J.; Wang, X.; Xie, B.; Yang, B.; Gao, Y.; Wu, C.; Meng, Q.; A highly sensitive bead-based flow cytometric competitive binding assay to detect SARS-CoV-2 neutralizing antibody activity. Front Immunol 2022, 13, 1041860.

54．Yang, B.; Jia, Y.; Meng, Y.; Xue, Y.; Liu, K.; Li, Y.; Liu, S.; Li, X.; Cui, K.; Shang, L.; Cheng, T.; Zhang, Z.; Hou, Y.; Yang, X.; Yan, H.; Duan, L.; Tong, Z.; Wu, C.; Liu, Z.; Gao, S.; Zhuo, S.; Huang, W.; Gao, G. F.; Qi, J.; Shang, G.; SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry. Proc Natl Acad Sci U S A 2022, 119 (4).

55．Yaigoub, H.; Tirichen, H.; Xin, X.; Shi, S.; Wu, C.; Li, R.; Li, Y.; Isolation of Viable Single Cells With High Yield and Purity Using a Small Amount of Human Kidney Tissue Biopsy. Front Cell Dev Biol 2022, 10, 822275.

56．Yaigoub, H.; Fath, N.; Tirichen, H.; Wu, C.; Li, R.; Li, Y.; Bidirectional crosstalk between dysbiotic gut microbiota and systemic lupus erythematosus: What is new in therapeutic approaches? Clin Immunol 2022, 244, 109109.

57．Wen, D.; Cui, J.; Li, P.; Xiong, Q.; Chen, G.; Wu, C.; Syndecan-4 assists Mycobacterium tuberculosis entry into lung epithelial cells by regulating the Cdc42, N-WASP, and Arp2/3 signaling pathways. Microbes Infect 2022, 24 (4), 104931.

58．Wang, L.; Li, J.; Xiong, Q.; Zhou, Y. A.; Li, P.; Wu, C.; Case Report: A Missense Mutation in Dyskeratosis Congenita 1 Leads to a Benign Form of Dyskeratosis Congenita Syndrome With the Mucocutaneous Triad. Front Pediatr 2022, 10, 834268.

59．Tufail, M.; Wu, C.; Targeting the IGF-1R in prostate and colorectal cancer: reasons behind trial failure and future directions. Ther Deliv 2022, 13 (3), 167-186.

60．Tufail, M.; Wu, C.; Psychological impact of COVID-19 pandemic on Parkinson's disease patients. Heliyon 2022, 8 (6), e09604.

61．Tufail, M.; Wu, C.; RANK pathway in cancer: underlying resistance and therapeutic approaches. J Chemother 2022, 1-14.

62．Tufail, M.; Cui, J.; Wu, C.; Breast cancer: molecular mechanisms of underlying resistance and therapeutic approaches. Am J Cancer Res 2022, 12 (7), 2920-2949.

63．Shah, P. T.; Tufail, M.; Wu, C.; Xing, L.; THP-1 cell line model for tuberculosis: A platform for in vitro macrophage manipulation. Tuberculosis (Edinb) 2022, 136, 102243.

64．Ma, Y.; Sun, W.; Zhao, L.; Yao, M.; Wu, C.; Su, P.; Yang, L.; Wang, G.; Generation of an mESC model with a human hemophilia B nonsense mutation via CRISPR/Cas9 technology. Stem Cell Res Ther 2022, 13 (1), 353.

65．Liu, Y.; Sun, X.; Zhang, J.; Gao, F.; Yu, L.; Dong, L.; Zhang, G.; Wu, C.; Isolation and characterisation of Pulsatilla Radix-utilising bacteria Pediococcus pentosaceus PR-1 from human faeces. FEMS Microbiol Lett 2022, 369 (1).

66．Liu, Y.; Bahoussi, A. N.; Wang, P. H.; Wu, C.; Xing, L.; Complete genome sequences of classical swine fever virus: Phylogenetic and evolutionary analyses. Front Microbiol 2022, 13, 1021734.

67．Li, P.; Wu, Y.; Wu, H.; Xiong, Q.; Zhao, N.; Chen, G.; Wu, C.; Xiao, H.; Functional Characterization of FH Mutation c.557G>A Underlies Uterine Leiomyomas. Int J Mol Sci 2022, 23 (3).

68．Li, P.; Lan, W.; Li, J.; Zhang, Y.; Xiong, Q.; Ye, J.; Wu, C.; Xiao, H.; Identification and Functional Evaluation of a Novel TBX4 Mutation Underlies Small Patella Syndrome. Int J Mol Sci 2022, 23 (4).

69．Li, J.; Gao, Z.; Chen, J.; Cheng, R.; Niu, J.; Zhang, J.; Yang, Y.; Yuan, X.; Xia, J.; Mao, G.; Liu, H.; Dong, Y.; Wu, C.; Development of a panel of three multiplex allele-specific qRT-PCR assays for quick differentiation of recombinant variants and Omicron subvariants of SARS-CoV-2. Front Cell Infect Microbiol 2022, 12, 953027.

70．Hussain, B.; Xie, Y.; Jabeen, U.; Lu, D.; Yang, B.; Wu, C.; Shang, G.; Activation of STING Based on Its Structural Features. Front Immunol 2022, 13, 808607.

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