Jianguo Li  Ph.D
	Associate Professor & Master Supervisor
	Email：lijg@sxu.edu.cn

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Research Interests

Gut microbiota has been associated with almost all spectrum of human diseases, and has been proved to be causative agents of several diseases including obesity, depressive disorder etc. However, which member of gut microbiota is responsible for such key functions and what is the underlying mechanisms are largely unknown. My group is trying to expand the association and causative relationship between gut microbiota and disease, and explore the key member and key working mechanisms, especially in airway infectious disease.

Research Graduate Student

Current Projects

1. Study the role of gut microbita in airway infectious diseases, including influenza and mycobacterium tuberculosis infections. Explore the key members and key mechanisms of gut microbita.

2. Study the role of gut microbiota in hypertension, especially in metabolic hypertension, gestational hypertension and sleep-disordered breathing syndrome complicated with hypertension. Explore the key members and key mechanisms of gut microbita.

Selected publications

1. Li J(#)(*), Cheng R, Bian Z, Niu J, Xia J, Mao G, Liu H, Wu C, Hao C(*). Development of multiplex allele-specific RT-qPCR assays for differentiation of SARS-CoV-2 Omicron subvariants. Applied Microbiology and Biotechnology, 2024, 108(1): 1-17. (SCI二区Top，IF=5.56)

2. Li J(#)(*), Gao Z, Chen J, Cheng R, Niu J, Zhang J, Yang Y, Yuan X, Xia J, Mao G, Liu H, Dong Y, Wu C(*). Development of a panel of three multiplex allele-specific qRT-PCR assays for quick differentiation of recombinant variants and Omicron subvariants of SARS-CoV-2. Frontiers in Cellular and Infection Microbiology, 2022, 12: 953027. (SCI二区，IF=6.07)

3. Xiao Y(#), Li Z(#), Wang X, Wang Y, Wang Y, Wang G, Ren L(*), Li J(*). Comparison of three TaqMan real-time reverse transcription-PCR assays in detecting SARS-CoV-2. Journal of Virological Methods, 2021, 288: 114030. (SCI四区，IF=2.1）

4. Li J(#)(*), Li Z, Cui X, Wu C(*). Bayesian phylodynamic inferences on the temporal evolution and global transmission of SARS-CoV-2. Journal of Infection, 2020, 81(2): 318-356. (SCI二区，IF=6.1)

5. Liu Y, Wang Y, Wang X, Xiao Y, Chen L, Guo L, Li J(*), Ren L(*), Wang J. Development of two TaqMan real-time reverse transcription-PCR assays for the detection of severe acute respiratory syndrome coronavirus-2. Biosafety and Health, 2020, 2(4): 232-237.

6. Li X(#), Huang Y(#), Song L, Xiao Y, Lu S, Xu J, Li J(*), Ren Z(*). Lactobacillus plantarum prevents obesity via modulation of gut microbiota and metabolites in high-fat feeding mice. Journal of Functional Foods, 2020, 73: 104103. （SCI二区，IF=4.5）

7. Zhao C (#), Ge J(#), Jiao R, Li X, Li Y, Quan H, Xu X, Li J(*), Guo Q(*), Wang W(*). 1H-NMR based metabolomic profiling of cord blood in gestation hypothyroidism. Annals of Translational Medicine, 2020, 8(6): 296. (SCI二区， IF=3.7)

8. Li J(#)(*), Jia X, Wang C, Wu C, Qin X(*). Altered gut metabolome contributes to depression-like behaviors in rats exposed to chronic unpredictable mild stress. Translational Psychiatry, 2019, 9: 40.（SCI二区，IF=5.2）

9. Li J(#)(*), Hou L, Wang C, Jia X, Qin X(*), Wu C. Short Term Intrarectal Administration of Sodium Propionate Induces Antidepressant-Like Effects in Rats Exposed to Chronic Unpredictable Mild Stress. Frontiers in Psychiatry, 2018, 9: 454.（SCI二区，IF=3.1）

10. Li J(#), Hao C(#), Liu X, Qin X(*). Differential evolutionary dynamics of Enterovirus D68 from countries of different continents. Future virology, 2017, 12 (1): 29-35. (SCI四区，IF=1.1）

11. Hao C(#), Hao C(#), Luo J, Li J(*). Genomic features of coxsackievirus A6 correlate with herpangina and hand, foot and mouth disease. Future Virology, 2016, 11 (4): 259-271. （SCI四区，IF=1.1）

12. Lu G(#), Li J(#), Xie Z, Liu C, Guo L, Guy V , Shen K, Wang J(*). Human Metapneumovirus Associated with Community-acquired Pneumonia in Children in Beijing, China. Journal of Medical Virology, 2013, 85 (1):138-143. （SCI四区，IF=2.4）

13. Li J(#), Wang Z(#), Gonzale R, Xiao Y, Zhou H, Zhang J, Paranhos-Baccalà G, Vernet G, Jin Q, Wang J(*), Hung T(*). Prevalence of human metapneumovirus in adults with acute respiratory tract infection in Beijing, China. Journal of Infection, 2012, 64(1):96-103. （SCI二区，IF=3.8）

14. 侯璐文(#)、吴长新、秦雪梅、李建国(*). 肠道微生物功能宏基因组学与代谢组学关联分析分方法研究进展. 微生物学报. 2019, 58(9): 1813-1822. (一级主学报)

15. 贾雪洋(#)，任红宇，聂旭冬，秦天(*)，李建国(*). 下呼吸道感染病原体检测方法研究进展. 2019, 35(3): 263-270.（二级主学报）

16. 王翠(#)，贾雪洋，侯璐文，秦雪梅，李建国(*). 基于GC-MS代谢组学研究抑郁大鼠血浆代谢物变化规律. 药学学报，2018, 53(6): 980-986. (一级主学报)