Ting Liu, PhD
	Lecturer, Master Advisor
	Email: tingliu@sxu.edu.cn

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Ting Liu, female, master supervisor, graduated from Auburn University in the United States. A lecturer at the Institutes of Biomedical Sciences, and the Secretary of the Fourth Party Branch of Postgraduate Students in the School of Life Science.

Research：

GPCRs (G protein-coupled receptors) are widely expressed in various tissues of the body and regulate multiple signaling pathways. They are one of the important targets for drug development. In different diseases, such as obesity, diabetes, and some rare diseases, the signals mediated by most GPCRs are dysregulated, which severely hinders cellular physiology. Therefore, our research group, through studying the pharmacological and physiological functions of GPCRs related to diseases (including rare diseases), and combining with the characteristics of their structural variations, further reveals the molecular mechanisms of diseases.

1. Study on the pharmacological functions of CXCR4 mutants related to WHIM syndrome.

2. Study on the pharmacological and physiological functions of melanocortin receptors related to energy metabolism.

Master students:

Research Projects:

1. Basic Research Program of Shanxi Province, Youth Project, 202303021222033, Study on the allosteric regulation of the pharmacological and physiological functions of CXCR4^WHIM Mutants by heterodimerization, from January 2024 to December 2026, with a funding of 50,000 yuan, currently in progress, the principal investigator.

Publications：

1. Liu T, Ji R, and Tao Y*. Naturally occurring mutant GPCRs associated with obesity and type 2 diabetes mellitus. Pharmacol Ther. 2022 Jun; 234: 108044.

2. Liu T, Yi T, Yang D, and Tao Y*. Regulation of melanocortin-5 receptor pharmacology by two isoforms of MRAP2 in ricefield eel (Monopterus albus). Gen Comp Endocrinol. 2021 Dec 1; 314:113928.

3. Wen Z^#, Liu T^#, Qin C, Zou Y, Wang J, Li R, and Tao Y*. MRAP2 interaction with melanocortin-4 receptor in snakehead (Channa argus). Biomolecules. 2021 Mar 23; 11(3): 481.

4. Ji R^#, Liu T^#, Hou Z, Wen H, Tao Y*. Divergent pharmacology and biased signaling of the four melanocortin-4 receptor isoforms in rainbow trout (Oncorhynchus mykiss), Biomolecules. 2023 Aug 16; 13(8): 1248.

5. Ji R^#, Huang L^#, Wang Y, Liu T, Fan S, Tao M, and Tao Y*. Topmouth culter melanocortin-3 receptor: regulation by two isoforms of melanocortin-2 receptor accessory protein 2. Endocr Connect. 2021 Nov 15; 10(11):1489-1501.

6. Tao M^#, Ji R^#, Huang L, Fan S, Liu T, Liu S and Tao Y*. Regulation of melanocortin-4 receptor pharmacology by two isoforms of melanocortin receptor accessory protein 2 in topmouth culter (Culter alburnus). Front Endocrinol. 2020 Aug 14; 11:538.

7. Liu T, Li Q*, Kong L and Yu H. Comparison of microsatellites and SNPs for pedigree analysis in the Pacific oyster Crassostrea gigas. Aquacult Int. 2017 Mar 9; 25:1507-1519.

8. Liu T, Li Q*, Song J and Yu H. Development of genomic microsatellite multiplex PCR using dye-labeled universal primer and its validation in pedigree analysis of Pacific oyster (Crassostrea gigas). J Ocean Univ China. 2017 Jan 8; 16(1):151-160.

9. Wan S, Li Q*, Liu T, Yu H and Kong L. Heritability estimates for shell color-related traits in the golden shell strain of Pacific oyster (Crassostrea gigas) using a molecular pedigree. Aquaculture. 2017 Jul 1; 476:65-71.

Patents：

Li Q, Liu T, Yu H. The microsatellite multiplex PCR method used for pedigree analysis of Pacific oyster (Crassostrea gigas). CN201610018599.0.