Guangxin Chen Ph.D
	Lecturer Master & Supervisor
	Email: chengx@sxu.edu.cn

---

Research interests

The research group is dedicated to the research on the immunopathological pathogenesis of pathogen infectious diseases and also conducts studies on intestinal immunity. Over the past five years, it has presided over the Youth Project of the National Natural Science Foundation, the General Project of the Postdoctoral Science Foundation, the Central Guiding Local Science and Technology Development Fund Project, etc. The specific research directions are as follows:

1、Interaction between Mycobacterium tuberculosis proteins and host proteins:

This research mainly focuses on identifying Mycobacterium tuberculosis proteins involved in the pyroptosis of host cells. Meanwhile, it also delves into the interaction mechanisms between Mycobacterium tuberculosis proteins and host proteins.

2、Intestinal immunity:

At present, the core of the research lies in elucidating the functions and underlying mechanisms of key molecules (such as BTNL2, NRF2, NLPR6, NLRP3, GPR120) and cells (specifically γδ T lymphocytes) in intestinal oxidative stress and inflammatory injury. Additionally, investigations are being carried out on nutrients that target these key molecules to preserve intestinal homeostasis.

Major Enrollment

Genetics，Bioengineering and Biotechnology

Research Graduate Students

Funding

1. Project funded by the Central Government's Guiding Fund for Local Scientific and Technological Development from the Science and Technology Department of Shanxi Province. Project No.: YDZJSX20231A005. Title: Research on the Mechanism of BTNL2 in Inhibiting the Infection of Intestinal Tissues by Mycobacterium tuberculosis. Duration: September 2023 - September 2026. Funding: 400,000 RMB. Role: Principal Investigator.

2. Youth Fund of the National Natural Science Foundation of China. Project No.: 32202698. Title: Mechanism of BTNL2 in Inhibiting Intestinal Inflammatory Damage in IUGR Piglets Mediated by γδT Lymphocyte Activation and Its Nutritional Regulation. Duration: January 2023 - December 2025. Funding: 300,000 RMB. Role: Principal Investigator.

3. General Program of the 71st Batch of China Postdoctoral Science Foundation. Project No.: 2022M710476. Title: Screening of Nutrients for Targeted Regulation of BTNL2 to Inhibit Intestinal Inflammatory Damage in IUGR Piglets. Duration: July 2022 - October 2023. Funding: 80,000 RMB. Role: Principal Investigator.

4. Youth Fund of the Natural Science Foundation of Shanxi Province. Project No.: 201901D211142. Title: Research on the Influence and Mechanism of SDC4 on the Invasion of Lung Epithelial Cells by M. tuberculosis. Duration: September 2019 - September 2022. Funding: 30,000 RMB. Role: Principal Investigator.

5. Scientific and Technological Innovation Project of Higher Education Institutions in Shanxi Province. Project No.: 2019L0035. Title: Research on the Mechanism of ASAP1 in Inhibiting the Escape of Mtb from Macrophages. Duration: January 2020 - December 2021. Funding: 20,000 RMB. Role: Principal Investigator.

6. Career Startup Funding for Chen Guangxin from the Central Government. Duration: January 2019 - December 2022. Funding: 230,000 RMB. Role: Principal Investigator.

Publications

1. Guangxin Chen^#, Lin Shen^#, Hong Hu, Yazhi Feng, Da Wen, Yiyao Liu, Huizhe Zhai, Wei Sun, Meifen Wang, Xinghua Lei, Ping Li, Qiuhong Xiong, Changxin Wu. (2024) Sulforaphane Inhibits Oxidative Stress and May Exert Anti-Pyroptotic Effects by Modulating NRF2/NLRP3 Signaling Pathway in Mycobacterium tuberculosis-Infected Macrophages. Microorganisms, 12(6):1191.

2. Guangxin Chen^#, Da Wen^#, Lin Shen, Yazhi Feng, Qiuhong Xiong, Ping Li, Zhonghua Zhao*. Cepharanthine exerts antioxidant and anti-Inflammatory effects in lipopolysaccharide (LPS)-induced macrophages and DSS-induced colitis mice. Molecules, 2023, 28.

3. Guangxin Chen, Ziyue Yang, Da Wen, Ping Li, Qiuhong Xiong, Changxin Wu*. (2023) Oridonin inhibits Mycobacterium marinum infection induced oxidative stress in vitro and in vivo. Pathogens, 12, (6).

4. Yang Liu, Yuxin Lei, Jianwei Li, Yuze Ma, Xueyin Wang, Fanhua Meng, Yujing Wu, Na Wang, Jing Liang, Caiquan Zhao, Yang Yang, Guangxin Chen*, Shuixing Yu*.G protein-coupled receptor 120 mediates host defense against clostridium perfringens infection through regulating NOD-like receptor family pyrin domain-containing 3 inflammasome activation. Journal of Agricultural and Food Chemistry, 2023,71, (18), 7119-7130. 并列通讯作者.

5. Da Wen, Jia Cui, Ping Li, Qiuhong Xiong, Guangxin Chen*, Changxin Wu*. Syndecan-4 assists Mycobacterium tuberculosis entry into lung epithelial cells by regulating the Cdc42, N-WASP, and Arp2/3 signaling pathways. Microbes and Infection, 2022, 24(4): 104931. 并列通讯作者.

6. Guangxin Chen^#, Ziyue Yang^#, Da Wen^#, Jian Guo, Qiuhong Xiong, Ping Li, Liping Zhao, Junping Wang*, Changxin Wu*, Lina Dong*. Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis. Immunity inflammation and disease, 2021, 9 (3), 959-970.

7. Guangxin Chen, Xin Ran, Bai Li, Yuhang Li, Dewei He, Bingxu Huang, Shoupeng Fu, Juxiong Liu, Wei Wang. Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model. EBioMedicine, 2018, 30.

8. Guangxin Chen, Bingxu Huang, Shoupeng Fu, Bai Li, Xin Ran, Dewei He, Liqiang Jiang, Yuhang Li, Liwei Xie, Juxiong Liu and Wei Wang. G Protein-Coupled Receptor 1 109A and Host Microbiota Modulate Intestinal Epithelial Integrity during Sepsis. Frontiers in Immunology.

9. Guangxin Chen, Shoupeng Fu, Wenqian Feng, Bingxu Huang, Shiyao Xu, Wei Wang and Juxiong Liu. AMP010014A09 in Sus Scrofa Encodes an Analog of G Protein-Coupled Receptor 109A, Which Mediates the Anti-Inflammatory Effects of Beta-Hydroxybutyric Acid. Cellular physiology and biochemistry, 2017, 42, 1420-1430.

10. Guangxin Chen, Juxiong Liu, Liqiang Jiang, Xin Ran, Dewei He, Yuhang Li, Bingxu Huang, Wei Wang, Shoupeng Fu. Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson's Disease in Rats. International journal of molecular sciences 2017, 19, (1).

11. Guangxin Chen, Juxiong Liu, Bingxu Huang, Xin Ran, Liqiang Jiang, Yuhang Li, Wei Wang, Shoupeng Fu. Peiminine protects dopaminergic neurons from inflammation-induced cell death by inhibiting the ERK1/2 and NF-κB signalling pathways. International Journal of Molecular Sciences 2018, 19(3).

12. Guangxin Chen, Zhenhua Gao, Wenhui Chu, Zan Cao, Chunyi Li, Haiping ZhaoZhao. Effects of Chromium Picolinate on Fat Deposition, Activity and Genetic Expression of Lipid Metabolism-Related Enzymes in 21 Day Old Ross Broilers. Asian-Australasian Journal of Animal Science.2017.

13. Wenqian Feng^#, Yancheng Wu^#, Guangxin Chen^#, Shoupeng Fu, Bai Li, Bingxu Huang, Dali Wang, Wei Wang and Juxiong Liu. Sodium Butyrate Attenuates Diarrhea in Weaned Piglets and Promotes Tight Junction Protein Expression in Colon in a GPR109A-Dependent Manner.  Cellular physiology and biochemistry, 2018; 47:1617-1629. (SCI, IF=5.104). 并列第一作者

14. Xin Ran^#, Yuhang Li^#, Guangxin Chen^#, Shoupeng Fu, Dewei He, Bingxu Huang, Libin Wei, Yuanqing Lin, Yingcheng Guo and Guiqiu Hu. Farrerol Ameliorates TNBS-Induced Colonic Inflammation by Inhibiting ERK1/2, JNK1/2, and NF-κB Signaling Pathway. International Journal of Molecular Sciences 2018, 19(7). (IF=5.6). 并列第一作者.