Xiaoqin La  Ph.D
	Lecturer & Master Supervisor
	Email：laxiaoqin@sxu.edu.cn

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      Xiaoqin La, female, holds a doctorate degree and serves as a lecturer and a supervisor for master's degree candidates. She is the counselor for the 2024 postgraduate students of the School of Life Sciences and the secretary of the Third Party Branch of Postgraduate Students in the School of Life Sciences. She once served as the counselor for the postgraduate students of the classes of 2019 and 2021, and has been awarded the honorary title of "Excellent Counselor" several times. The classes she was in charge of have all been honored with the title of "Advanced Postgraduate Class Collective".

   In recent years, she has presided over one national-level scientific research project, three provincial-level scientific research projects, and one provincial-level teaching reform project. She has been responsible for teaching undergraduates courses such as "Cell Biology" and "Comprehensive Biotechnology Experiment", as well as teaching "Medical Cell Biology" to postgraduate students majoring in relevant fields. As the primary instructor, she has guided students to win multiple national and provincial competition awards, including those in the National College Students' Life Science Competition (Scientific Inquiry Category).

Major Research Direction:

Conduct research focusing on the regulation of the stemness of tumor cells and targeted intervention, opening up new paths for solving the problem of tumor drug resistance and developing innovative anti-tumor drugs. The current research mainly focuses on:

The application of probiotics and prebiotics in the prevention and control of chronic diseases;

The potential intervention efficacy of postbiotics in the process of regulating the stemness of colorectal cancer;

The potential value and mechanism of action of characteristic plant resources in Shanxi Province in the regulation and intervention of the stemness of colorectal cancer.

Major Enrollment:

1. Academic master: Biochemistry and molecular biology, genetics

2. Professional master: Food processing and safety

Research Graduate Students

Representative academic papers:

1. Xiaoqin La, Xiaoting He, Jingyi Liang, Zhaoyan Zhang, Hanqing Li, Yizhi Liu, Ting Liu, Zhuoyu Li, Changxin Wu. Gastroprotective Effect of Isoferulic Acid Derived from Foxtail Millet Bran against Ethanol-Induced Gastric Mucosal Injury by Enhancing GALNT2 Enzyme Activity [J]. Nutrients, 2024, 16(13):2148.

2. Xiaoqin La, Zhaoyan Zhang, Jingyi Liang, Hanqing Li, Yan Pang, Xiaoting He, Yurui Kang, Changxin Wu, Zhuoyu Li. Isolation and purification of flavonoids from quinoa whole grain and its inhibitory effect on lipid accumulation in nonalcoholic fatty liver disease by inhibiting the expression of CD36 and FASN [J]. The Journal of the Science of Food and Agriculture, 2024,105(2):1330-1342.

3. Xiaoqin La, Zhaoyan Zhang, Cunli Dong, Hanqing Li, Xiaoting He, Yurui Kang, Changxin Wu, Zhuoyu Li. Isorhamnetin in Quinoa Whole-Grain Flavonoids Intervenes in Non-Alcoholic Fatty Liver Disease by Modulating Bile Acid Metabolism through Regulation of FXR Expression [J]. Foods, 2024, 13:3076.

4. Xiaoqin La, Lichao Zhang, Zhuoyu Li, Hanqing Li, Yufei Yang. (-)-Epigallocatechin Gallate (EGCG) Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU by Inhibiting GRP78/NF-κB/miR-155-5p/MDR1 Pathway [J]. Journal of Agricultural and Food Chemistry, 2019,67(9):2510–2518.

5. Xiaoqin La, Lichao Zhang, Zhuoyu Li, Peng Yang, Yingying Wang. Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells [J]. Oncotarget, 2017,8(13):20909-20924.

6. Xiaoqin La, Lichao Zhang, Hanqing Li, Zhuoyu Li, Guisheng Song, Peng Yang, Yufei Yang. Ajuba receptor mediates the internalization of tumor-secreted GRP78 into macrophages through different endocytosis pathways [J]. Oncotarget, 2018,9(21):15464-15479.

7. Lichao Zhang^#, Xiaoqin La^#, Jinmiao Tian, Hanqing Li, Aiping Li, Yizhi Liu, Changxin Wu, Zhuoyu Li*, The phytochemical vitexin and syringic acid derived from foxtail fillet bran inhibit breast cancer cells proliferation via GRP78/SREBP-1/SCD1 signaling axis [J]. Journal of Functional Foods. 2021, 85, 104620.

8. Yuxuan An, Xiaoqin La, Songtao Li, Jinmiao Tian, Xiaxia Fan, Kaili Cui, Lichao Zhang, Zhuoyu Li. Polyphenols from whole millet grain (Setaria italica) alleviate glucose and lipid homeostasis in diet-induced-obese mice by increasing endogenous GLP-1 [J]. The Journal of the Science of Food and Agriculture, 2023, 103(15):7785-7797.

9. Xiaoqin La, Yizhi Liu, Lichao Zhang, Hanqing Li, Zhuoyu Li. Protective Effect of Polyphenols from Rice Bran on Alcohol-induced Gastric Mucosal Injury [J]. Food Science, 2022, 43(13): 64-71.

10. Xiaoqin La, Xiaodi Jin, Lichao Zhang, Zhuoyu Li. Berberine Enhances the Sensitivity of Colorectal Cancer Cells to 5-Fluorouracil by Targeting GRP78 [J]. Journal of Shanxi University (Natural Science Edition), 2020, 43(1): 164-172.

Scientific Research Project:

1. National Natural Science Foundation of China, Young Scientists Fund Project, Discovery of Wnt3a Antagonists in the Peptide Components of Quinoa and the Mechanism of Their Action in Reversing the Chemoresistance of Colorectal Cancer Mediated by Stemness (32300328), 2024-01-2026-12, 300,000 yuan, Runing Projects, Project Director.

2. Natural Science Foundation of Shanxi Province, General Program, Active Ingredients and Action Mechanism of Flavonoids from Foxtail Millet in Reversing Metabolic Reprogramming by Regulating Succinate Dehydrogenase and Their Antitumor Activity against Breast Cancer (202203021221024), 2023-01-2025-12, 90,000 yuan, Runing Projects, Project Director.

3. Scientific and Technological Innovation Project of Higher Education Institutions in Shanxi Province. Molecular Mechanism of Polyphenols from Rice Bran in Inhibiting the Proliferation of Breast Cancer Cells by Regulating Lipid Metabolism (2020L0045), 2020-03-2022-02, 20,000 yuan, has been finished, Project Director.

4. Applied Basic Research Program of Shanxi Province, Study on the mechanism of bound polyphenol of inner shell inhibiting breast cancer cell proliferation by regulating lipid metabolism (201901D211128), 2019.09-2022.09, 30,000 yuan, has been finished, Project Director.

5. Teaching Reform and Innovation Project of Higher Education in Shanxi Province, , Exploration and practice of cell biology curriculum construction based on "four-dimensional" hybrid teaching reform (J2021058), 2021.08-2023.08, has been finished, Project Director.