Guijun Shang  Ph.D
	Professor   Doctoral Supercisor
	Email： guijun.shang@sxu.edu.cn

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Personal Profile

Prof. Guijun Shang earned his bachelor's degree from Northwest A&F University and his Ph.D. from the State Key Laboratory of Microbial Technology at Shandong University. He subsequently completed his postdoctoral training in the Department of Pharmacology at the University of Texas Southwestern Medical Center (UTSW) in the United States.

 

He is currently a principal investigator at the Institute of Biomedical Research, Shanxi University. Dr. Shang's research group is dedicated to unraveling the mechanisms of innate immune signal transduction and pathogen-host interactions. His work integrates multidisciplinary approaches, including biophysics, cell biology, and biochemistry, with the ultimate goal of providing a critical foundation for discovering new targets in infection immunology and developing innovative strategies for anti-infection immunity and tumor immunotherapy.

 

Research Directions

The innate immune system is the host's first line of defense against pathogen invasion. Dr. Shang's research focuses on how host innate immune molecules recognize genetic materials (DNA and RNA) from viruses or pathogenic bacteria to initiate immune responses. Key research directions include:

 1. Molecular Mechanisms: Elucidating the structural and functional intricacies of the innate immune cGAS-STING signaling pathway.

 2. Translational Applications: Conducting drug development and exploration of therapeutic applications based on the cGAS-STING pathway.

 3. Host-Pathogen Interface: Investigating the complex mechanisms of pathogen-host interactions.

 

Funding Sources National Natural Science Foundation of China (NSFC); the National Key R&D Program of the Ministry of Science and Technology; Shanxi Provincial Key Laboratory; Shanxi Provincial Fund for Distinguished Young Scholars; Shanxi Provincial Major Science and Technology Projects; International Cooperation Projects.

 

Selected publications (#: co-corresponding author; *: co-first author)：

1. Yang Y, Liu Y, Ma X, Zhao X, Cao J, Liu Y, Li S, Wu J, Gao Y, Chen L, Wu C, Shang G#, Liu S#, Lu D#. Structural insights into distinct filamentation states reveal a regulatory mechanism for bacterial STING activation. mBio. 2025 Sep 10;16(9):e0038825. doi: 10.1128/mbio.00388-25.

 2. Xun J, Zhang Z, Lv B, Lu D, Yang H, Shang G#, and Tan X#. A conserved ion channel function of STING mediates non-canonical autophagy and cell death. EMBO reports. 2024 Feb;25(2):544-569.

 3. Liu S, Yang B, Hou Y, Cui K, Yang X, Li X, Chen L, Liu S, Zhang Z, Jia Y, Xie Y, Xue Y, Li X, Yan B, Wu C, Deng W, Qi J, Lu D#, Gao F#, Wang P#, and Shang G#. The mechanism of STING autoinhibition and activation. Molecular Cell. 2023 May 4;83(9):1502-1518.e10

 4, Lu D*, Shang G*, Li J, Lu Y, Bai X-C, Zhang X. Activation of STING by targeting a binding site in the transmembrane region. Nature. 2022 Apr;604(7906):557-562.

 5, Yang B, Jia Y, Meng Y, Xue Y, Liu K, Li Y, Liu S, Li X, Cui K, Shang L, Cheng T, Zhang Z, Hou Y, Yang X, Yan H, Duan L, Tong Z, Wu C, Liu Z, Gao S, Zhuo S, Huang W#, Gao GF#, Qi J#, Shang G#. SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2117576119.

 6, Cong X, Yuan Z, Du Y, Wu B, Lu D, Wu X, Zhang Y, Li F, Wei B, Li J, Wu J, Xu S, Wang J, Qi J#, Shang G#, Gu L#. Crystal structures of porcine STING^CBD-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins. J Biol Chem. 2019 Jul 26;294(30):11420-11432.

 7, Shang G*, Zhang C*, Chen ZJ, Bai XC, Zhang X. Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP. Nature. 2019 Mar;567(7748):389-393. 

 8, Zhang C*, Shang G*, Gui X, Zhang X, Bai XC, Chen ZJ. Structural basis of STING binding with and phosphorylation by TBK1. Nature. 2019 Mar;567(7748):394-398.

 9, Zhu D*, Wang L*, Shang G*, Liu X*, Zhu J*, Lu D, Wang L, Kan B, Zhang JR, Xiang Y. Structural biochemistry of a Vibrio cholerae dinucleotide cyclase reveals cyclase activity regulation by folates. Mol Cell. 2014 Sep 18;55(6):931-937.

 10, Shang G*, Zhu D*, Li N*, Zhang J*, Zhu C, Lu D, Liu C, Yu Q, Zhao Y, Xu S, Gu L. Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP. Nat Struct Mol Biol. 2012 Jun 24;19(7):725-7.