熊秋宏   博士
	副教授   博士生导师
	Email：qxiong@sxu.edu.cn

　

---

教育和工作经历：

2004.09-2008.06 山西师范大学   本科

2008.09-2011.06 吉林大学   硕士

2011.10-2015.06 德国科隆大学   博士（国家公派留学奖学金）

2015.07-2016.03 德国科隆大学   博士后

2016.08-2019.11 山西大学生物医学研究院  讲师

2019.12-今 山西大学生物医学研究院 副教授

主要研究方向：

  自噬（autophagy）作为细胞内主要的溶酶体降解途径，对细胞稳态和细胞正常生理功能的维持具有十分重要的作用，自噬异常导致众多疾病的发生，例如神经退行性疾病等。自噬与细胞内另一降解途径--蛋白酶体（proteasome）之间存在Crosstalk，它们之间相互联系，相互影响，共同维持蛋白和细胞稳态。本课题组主要研究自噬与蛋白酶体的相互关系，以及自噬相关蛋白在人类疾病发生过程中的作用，阐明相关疾病的病理生理机制，为新药研发和临床治疗奠定基础。

研究方向：

1. 自噬与蛋白酶体的关系

2. 自噬相关蛋白在人类疾病发生发展中的作用

主持项目：

1.  BPAN病人大脑黑质部位铁沉积对黑质神经细胞的影响及机制研究，山西省回国留学人员科研教研资助项目（2023-021），2023.08-2026.07。

2. WDR45突变激活分子伴侣介导的自噬促进β-螺旋蛋白相关性神经变性病发生发展的分子机制研究，国家自然科学基金面上项目（82271905），2023.01-2026.12。

3. PI3Kδ过度活化综合征基因治疗技术临床前研究，中央引导地方科技发展资金项目（YDZJSX2022A007），2022.07-2025.06。

4. 原生动物盘基网柄菌自噬相关蛋白ATG16敲除导致蛋白酶体活性降低的机制研究，国家自然科学基金青年基金（31801972），2019.01-2021.12。

5. 自噬相关蛋白WDR45在神经退行性疾病BPAN中的功能研究，山西省自然科学基金青年基金（201801D221248），2018.12-2020.12。

6. 转铁蛋白受体TfR在神经退行性疾病BPAN病人脑铁沉积中的功能研究，山西省高等学校科技创新项目（2019L0096），2019.06-2021.06。

招生专业：

博士研究生：遗传学

学术型硕士：遗传学、生物化学与分子生物学、微生物学

专业型硕士：生物与医药（生物工程）

发表论文：

Xiong Q*, Eichinger L*. Model organisms to study autophagy. Cells. 2023, 12(18):2212. (SCI二区)

Chen G*, Wen D, Shen L, Feng Y, Xiong Q, Li P, Zhao Z*. Cepharanthine exerts antioxidant and anti-inflammatory effects in lipopolysaccharide (LPS)-induced macrophages and DSS-induced colitis mice. Molecules. 2023, 28(16):6070. (SCI二区)

Xiong Q*, Feng R, Fisher S, Karow M, Stumpf M, Meßling S, Nitz L, Müller S, Clemen C, Song N, Li P, Wu C, Eichinger L*. Proteasomes of autophagy-deficient cells exhibit alterations in regulatory proteins and a marked reduction in activity. Cells. 2023, 12(11):1514. (SCI二区)

Chen G, Yang Z, Wen D, Li P, Xiong Q, Wu C. Oridonin inhibits Mycobacterium marinum infection induced oxidative stress in vitro and in vivo. Pathogens. 2023, 12(6):799. (SCI三区)

Xiong Q*, Sun H, Xing W, Li X, Chen G, Zhao Z, Wu C*, Li P*. WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism. Free Radical Biology and Medicine. 2023, 201:89-97. (SCI一区Top)

Li P*, Lan W, Li J, Zhang Y, Xiong Q, Ye J, Wu C, Xiao H*. Identification and functional evaluation of a novel TBX4 mutation underlies small patella syndrome. International journal of molecular sciences. 2022, 23(4):2075. (SCI二区)

Li P*, Wu Y, Wu H, Xiong Q, Zhao N, Chen G, Wu C, Xiao H*. Functional characterization of FH mutation c.557G>A underlies uterine leiomyomas. International journal of molecular sciences. 2022, 23(3):1452. (SCI二区)

Wen D, Cui J, Li P, Xiong Q, Chen G*, Wu C*. Syndecan-4 assists Mycobacterium tuberculosis entry into lung epithelial cells by regulating the Cdc42, N-WASP, and Arp2/3 signaling pathways. Microbes and Infection, 2022:104931. (SCI四区)

Zhang Y#, Xiao H#, Xiong Q, Wu C*, Li P*. Two novel hydroxymethylbilane synthase splicing mutations predispose to acute intermittent porphyria. International journal of molecular sciences. 2021, 22(20):11008. （# co-first author）(SCI二区)

Xiong Q*, Song N, Li P, Fischer S, Konertz R, Wagle P, Glöckner G, Wu C*, Eichinger L*. RNAseq and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16. BMC Genomics. 2021, 22(1):444. (SCI三区)

Zhao N, Yang Y, Li P, Xiong Q, Xiao H*, Wu C*. Identification of two novel compound heterozygous EIF2AK3 mutations underlying Wolcott-Rallison Syndrome in a Chinese family. Frontiers in Pediatrics. 2021, 9:679646. (SCI三区)

Chen G, Yang Z, Wen D, Guo J, Xiong Q, Li P, Zhao L, Wang J*, Wu C*, Dong L*. Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis. Immunity, Inflammation and Disease. 2021, 9(3):959-970. (SCI三区)

Xiong Q*, Li X, Li W, Chen G, Xiao H, Li P*, Wu C*. WDR45 mutation impairs the autophagic degradation of transferrin receptor and promotes ferroptosis. Frontiers in Molecular Biosciences. 2021, 8:645831. (SCI二区)

Wang L, Xiong Q, Li P, Chen G, Tariq N, Wu C*. The negative charge of the 343 site is essential for maintaining physiological functions of CXCR4. BMC Molecular and Cell Biology. 2021, 22(1):8. (SCI三区)

李昕，李平，熊秋宏*. 自噬和铁死亡的相互联系. 中国细胞生物学学报. 2021, 43(1):144-151.

Han Y, Wang D, Guo J, Xiong Q, Li P, Zhou Y, Zhao B*. A novel splicing pathogenic variant in COL1A1 causing osteogenesis imperfecta (OI) type I in a Chinese family. Molecular Genetics & Genomic Medicine. 2020, 8(9):e1366. (SCI三区)

Karow M, Fisher S, Meßling S, Konertz R, Riehl J, Xiong Q, Rijal R, Wagle P, Clemen CS, Eichinger L*. Functional characterization of the autophagy ATG12~5/16 complex in Dictyostelium discoideum. Cells. 2020, 9(5):1179. (SCI二区)

Zhou Y, Li P*, Zhang Y, Xiong Q, Li C, Zhao Z, Wang Y, Xiao H*. Identification of a novel compound heterozygous IDUAmutation underlies Mucopolysaccharidoses type I in a Chinese pedigree. Molecular Genetics & Genomic Medicine. 2020, 8(1):e1058. (SCI三区)

Xiong Q*, Yang M, Li P, Wu C*. Bacteria exploit autophagy for their own benefit. Infection and Drug Resistance. 2019, 12:3205-3215. (SCI二区)

Xiong Q*, Li W, Li P, Zhao Z, Wu C*, Xiao H*. Functional evidence for a de novo mutation in WDR45 leading to BPAN in a Chinese girl. Molecular Genetics & Genomic Medicine. 2019, 7(9):e858. (SCI三区)

Li P*, Zhang L, Xiong Q, Wang Z, Cui X, Zhou Y, Wang Y, Xiao H*, Wu C*. Functional evaluation of a novel GLA causative mutation in Fabry disease. Molecular Genetics & Genomic Medicine. 2019, 7(9):e864. (SCI三区)

Li P*, Zhang L, Zhao N, Xiong Q, Zhou Y, Wu C*, Xiao H*. A novel α-Galactosidase A splicing mutation predisposes to Fabry disease. Frontiers in Genetics. 2019, 10:60. (SCI二区)

Xiong Q, Li W, Li P, Yang M, Wu C*, Eichinger L*. The role of ATG16 in autophagy and the ubiquitin proteasome system. Cells. 2019, 8(1):2. (SCI二区)

Xiao H, Xue Y, Liu Y, Li W, Zhao N, Xiong Q, Li P, Wu C*, Yang Y*. Novel de novo mutation in the autophagy gene WDR45 causes BPAN in a Chinese family. Journal of Molecular and Genetic Medicine. 2018, 12(4):381.

Xiong Q, Fischer S, Karow M, Müller R, Meßling S, Eichinger L*. ATG16 mediates the autophagic degradation of the 19S proteasomal subunits PSMD1 and PSMD2. European Journal of Cell Biology. 2018, 97(8):523-532. (SCI二区)

熊秋宏*，李文静，吴长新. 自噬和泛素-蛋白酶体系统的交联. 中国生物化学与分子生物学报. 2018, 34(11):1154-1159.

Xiong Q, Liu Y, Xue Y, Liu S, Wang J, Li P, Wu C, Yang Y*, Xiao H*. A novel de novo mutation in COL2A1 leading to spondyloephyseal dysplasia congenita in a Chinese family. Human Genome Variation. 2018, 5:17059.

Meβling S, Matthias J, Xiong Q, Fisher S, Eichinger L*. The two Dictyostelium discoideum autophagy 8 proteins have distinct autophagic functions. European Journal of Cell Biology. 2017, 96(4):312-324. (SCI二区)

Mesquita A, Cardenal-Muñoz E, Dominguez E, Muñoz-Braceras S, Nuñez-Corcuera B, Phillips BA, Tábara LC, Xiong Q, Coria R, Eichinger L, Golstein P, King JS, Soldati T, Vincent O, Escalante R*. Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model. Autophagy. 2017, 13(1): 24-40. (SCI一区)

Xiong Q, Ünal C, Matthias J, Steinert M, Eichinger L*. The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions. Open Biology. 2015, 5(4):150008.  (SCI二区)

Ma TH#, Xiong QH#, Yuan B, Jiang H, Gao Y, Xu JB, Liu SY, Ding Y*, Zhang GL, Zhao YM, Zhang JB*. Luteinizing hormone receptor splicing variants in bovine Leydig cells. Genetics and Molecular Research. 2012, 11(2):1721-30.（#共同第一作者，SCI四区）

Ma T, Jiang H, Gao Y, Zhao Y, Dai L, Xiong Q, Xu Y, Zhao Z, Zhang J*. Microarray analysis of differentially expressed microRNAs in non-regressed and regressed bovine corpus luteum tissue; microRNA-378 may suppress luteal cell apoptosis by targeting the interferon gamma receptor 1 gene. Journal of Applied Genetics. 2011, 52(4):481-6. (SCI四区)