熊秋宏  博士
	副教授   博士生导师
	Email：qxiong@sxu.edu.cn

　

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主要研究方向

自噬（autophagy）作为细胞内主要的溶酶体降解途径，对细胞稳态和细胞正常生理功能的维持具有十分重要的作用，自噬异常导致众多疾病的发生，例如神经退行性疾病等。自噬与细胞内另一降解途径--蛋白酶体（proteasome）之间存在Crosstalk，它们之间相互联系，相互影响，共同维持蛋白和细胞稳态。本课题组主要研究自噬与蛋白酶体的相互关系，以及自噬相关蛋白在人类疾病发生过程中的作用，阐明相关疾病的病理生理机制，为新药研发和临床治疗奠定基础。

研究方向：

1. 自噬与蛋白酶体的关系

2. 自噬相关蛋白在人类疾病发生发展中的作用

主持项目

1. 山西省科技合作交流专项。

2. 山西省回国留学人员科研资助项目。

3. 国家自然科学基金面上项目。

4. 中央引导地方科技发展资金项目。

5. 国家自然科学基金青年基金。

6. 山西省自然科学基金青年基金。

7. 山西省高等学校科技创新项目。

招生专业

博士研究生：遗传学

学术型硕士：遗传学

专业型硕士：生物与医药（生物技术与工程）

在读硕士研究生

发表论文

1. Qiuhong Xiong*, Huimin Sun, Yanlin Wang, Qian Xu, Yu Zhang, Mei Xu, Zhonghua Zhao, Ping Li*, Changxin Wu*. Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn. Lipids in Health and Disease, 2024, 23:91. (SCI二区)

2. Ping Li*, Yuqian Xi, Yanping Zhang, Abdus Samad, Wenli Lan, Ya Wu, Jiayu Zhao, Guangxin Chen, Changxin Wu, Qiuhong Xiong*. GLA mutations suppress autophagy and stimulate lysosome generation in Fabry disease. Cells. 2024, 13(5):437. (SCI二区)

3. Qiuhong Xiong*, Huimin Sun, Wenxiu Xing, Xin Li, Guangxin Chen, Zhonghua Zhao, Changxin Wu*, Ping Li*. WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism. Free Radical Biology and Medicine. 2023, 201:89-97. (SCI一区Top)

4. Qiuhong Xiong*, Ludwig Eichinger*. Model organisms to study autophagy. Cells. 2023, 12(18):2212. (SCI二区)

5. Qiuhong Xiong*, Rong Feng, Sarah Fisher, Malte Karow, Maria Stumpf, Susanne Meßling, Leonie Nitz, Stefan Müller, Christoph S Clemen, Ning Song, Ping Li, Changxin Wu, Ludwig Eichinger*. Proteasomes of autophagy-deficient cells exhibit alterations in regulatory proteins and a marked reduction in activity. Cells. 2023, 12(11):1514. (SCI二区)

6. Qiuhong Xiong*, Ning Song, Ping Li, Sarah Fischer, Roman Konertz, Prerana Wagle, Gernot Glöckner, Changxin Wu*, Ludwig Eichinger*. RNAseq and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16. BMC Genomics. 2021, 22(1):444. (SCI三区)

7. Qiuhong Xiong*, Xin Li, Wenjing Li, Guangxin Chen, Han Xiao, Ping Li*, Changxin Wu*. WDR45 mutation impairs the autophagic degradation of transferrin receptor and promotes ferroptosis. Frontiers in Molecular Biosciences. 2021, 8:645831. (SCI二区)

8. Qiuhong Xiong*, Min Yang, Ping Li, Changxin Wu*. Bacteria exploit autophagy for their own benefit. Infection and Drug Resistance. 2019, 12:3205-3215. (SCI二区)

9. Qiuhong Xiong*, Wenjing Li, Ping Li, Zhonghua Zhao, Changxin Wu*, Han Xiao*. Functional evidence for a de novo mutation in WDR45 leading to BPAN in a Chinese girl. Molecular Genetics & Genomic Medicine. 2019, 7(9):e858. (SCI三区)

10. Qiuhong Xiong, Wenjing Li, Ping Li, Min Yang, Changxin Wu*, Ludwig Eichinger*. The role of ATG16 in autophagy and the ubiquitin proteasome system. Cells. 2019, 8(1):2. (SCI二区)

11. Qiuhong Xiong, Sarah Fischer, Malte Karow, Rolf Müller, Susanne Meßling, Ludwig Eichinger*. ATG16 mediates the autophagic degradation of the 19S proteasomal subunits PSMD1 and PSMD2. European Journal of Cell Biology. 2018, 97(8):523-532. (SCI二区)

12. Qiuhong Xiong Q, Can Ünal, Jan Matthias, Michael Steinert, Ludwig Eichinger*. The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions. Open Biology. 2015, 5(4):150008.  (SCI二区)

13. Tenghe Ma^#, Qiuhong Xiong^#, Bao Yuan, Hao Jiang, Yan Gao, Jingbo Xu, Siyuan Liu, Yu Ding*, Guoliang Zhang, Yumin Zhao, Jiabao Zhang*. Luteinizing hormone receptor splicing variants in bovine Leydig cells. Genetics and Molecular Research. 2012, 11(2):1721-30.（^#共同第一作者，SCI四区）

14. 李昕，李平，熊秋宏*. 自噬和铁死亡的相互联系. 中国细胞生物学学报. 2021, 43(1):144-151.

15. 熊秋宏*，李文静，吴长新. 自噬和泛素-蛋白酶体系统的交联. 中国生物化学与分子生物学报. 2018, 34(11):1154-1159.