山西大学生物医学研究院

人才队伍

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吴长新

	吴长新博士
	教授博士生导师
	Email：cxw20@sxu.edu.cn

教育背景：

学士 1983.09-1988.07 临床兽医学中国扬州大学

硕士 1988.09-1991.06 预防兽医学中国扬州大学

博士 2002.01-2005.12 感染与免疫英国剑桥大学

工作经历：

全日职务

助教 1991.09-1994.08 中国扬州大学

讲师 1994.09-1999.04 中国扬州大学

教授 2003.09-2005.12 中国扬州大学

访问学者 1999.05-2000.08 英国剑桥大学

兼职研究员 2001.01-2003.12 英国动物健康研究所

助理研究员 2001.01-2003.12 英国剑桥大学

副研究员 2006.01-2009.02 英国剑桥大学

研究员 2009.03-2013.02 英国剑桥大学

高级研究员 2013.03-2018.06 英国剑桥大学 (终身)

教授 2018.06 至今中国山西大学

访问研究员 2018.06至今英国剑桥大学医学系和兽医学系

行政任职：

实验室副主任 2009.03-2015.05 英国剑桥大学医学系人类疾病遗传学实验室创始人

院长 2015.06至今中国山西大学生物医学研究院院长创始人

研究领域：

吴长新教授主要从事感染与免疫和人类疾病遗传学基础研究，聚焦地域性重大疾病病理机制与新干预技术研究。回国前后主持和参与国家基金项目、国家973项目、国家支撑计划、国家重点科技计划、Wellcome Trust、英国生物技术理事会和欧盟第七框架重大项目等项目。有关感染与免疫方面的主要科学与学术成就在《科学》、《自然》和《美国科学院学报》等期刊发表。获得Wellcome Trust国际青年科学家发展奖荣誉和剑桥大学海外奖学金委员会终生荣誉会员。

在英国剑桥大学学习和工作近二十年后，应山西大学邀请，在山西省海外高层次人才、山西省高层次引进人才创新团队、和山西省“三晋英才”支持计划等人才支持计划资助下，辞去剑桥大学工作职位，担任剑桥大学访问科学家，2018年正式加盟山西大学，组建山西大学生物医学研究员，担任生物医学研究院院长和人类重要疾病病理机制与新干预技术团队首席科学家，此后兼任剑桥大学医学院和兽医学院终身访问研究员。目前担任并山西省特聘专家、山西省干细胞产业创新联盟理事长、山西省生物工程学会常务理事、中国防痨协会标准委员会常务委员和山西省战略科学家。

代表作：

1. Liu, S.; Yang, B.; Hou, Y.; Cui, K.; Yang, X.; Li, X.; Chen, L.; Liu, S.; Zhang, Z.; Jia, Y.; Xie, Y.; Xue, Y.; Li, X.; Yan, B.; Wu, C.; Deng, W.; Qi, J.; Lu, D.; Gao, G. F.; Wang, P.; Shang, G., The mechanism of STING autoinhibition and activation. Mol Cell 2023, 83 (9), 1502-1518.e10.

2. Yang, B.; Jia, Y.; Meng, Y.; Xue, Y.; Liu, K.; Li, Y.; Liu, S.; Li, X.; Cui, K.; Shang, L.; Cheng, T.; Zhang, Z.; Hou, Y.; Yang, X.; Yan, H.; Duan, L.; Tong, Z.; Wu, C.; Liu, Z.; Gao, S.; Zhuo, S.; Huang, W.; Gao, G. F.; Qi, J.; Shang, G., SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry. Proc Natl Acad Sci U S A 2022, 119 (4).

3. Yaigoub, H.; Fath, N.; Tirichen, H.; Wu, C.; Li, R.; Li, Y., Bidirectional crosstalk between dysbiotic gut microbiota and systemic lupus erythematosus: What is new in therapeutic approaches? Clin Immunol 2022, 244, 109109.

4. Wen, D.; Cui, J.; Li, P.; Xiong, Q.; Chen, G.; Wu, C., Syndecan-4 assists Mycobacterium tuberculosis entry into lung epithelial cells by regulating the Cdc42, N-WASP, and Arp2/3 signaling pathways. Microbes Infect 2022, 24 (4), 104931.

5. Yang, C.; Ma, X.; Wu, J.; Han, J.; Zheng, Z.; Duan, H.; Liu, Q.; Wu, C.; Dong, Y.; Dong, L., Low serum calcium and phosphorus and their clinical performance in detecting COVID-19 patients. J Med Virol 2021, 93 (3), 1639-1651.

6. Li, J.; Li, Z.; Cui, X.; Wu, C., Bayesian phylodynamic inference on the temporal evolution and global transmission of SARS-CoV-2. J Infect 2020, 81 (2), 318-356.

7. Cuchet-Lourenço, D.; Eletto, D.; Wu, C.; Plagnol, V.; Papapietro, O.; Curtis, J.; Ceron-Gutierrez, L.; Bacon, C. M.; Hackett, S.; Alsaleem, B.; Maes, M.; Gaspar, M.; Alisaac, A.; Goss, E.; AlIdrissi, E.; Siegmund, D.; Wajant, H.; Kumararatne, D.; AlZahrani, M. S.; Arkwright, P. D.; Abinun, M.; Doffinger, R.; Nejentsev, S., Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation. Science 2018, 361 (6404), 810-813.

8. Curtis, J.; Luo, Y.; Zenner, H. L.; Cuchet-Lourenço, D.; Wu, C.; Lo, K.; Maes, M.; Alisaac, A.; Stebbings, E.; Liu, J. Z.; Kopanitsa, L.; Ignatyeva, O.; Balabanova, Y.; Nikolayevskyy, V.; Baessmann, I.; Thye, T.; Meyer, C. G.; Nürnberg, P.; Horstmann, R. D.; Drobniewski, F.; Plagnol, V.; Barrett, J. C.; Nejentsev, S., Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration. Nat Genet 2015, 47 (5), 523-527.

9. Yang, J.; Li, X.; Al-Lamki, R. S.; Wu, C.; Weiss, A.; Berk, J.; Schermuly, R. T.; Morrell, N. W., Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension. Arterioscler Thromb Vasc Biol 2013, 33 (1), 34-42.

10. Angulo, I.; Vadas, O.; Garçon, F.; Banham-Hall, E.; Plagnol, V.; Leahy, T. R.; Baxendale, H.; Coulter, T.; Curtis, J.; Wu, C.; Blake-Palmer, K.; Perisic, O.; Smyth, D.; Maes, M.; Fiddler, C.; Juss, J.; Cilliers, D.; Markelj, G.; Chandra, A.; Farmer, G.; Kielkowska, A.; Clark, J.; Kracker, S.; Debré, M.; Picard, C.; Pellier, I.; Jabado, N.; Morris, J. A.; Barcenas-Morales, G.; Fischer, A.; Stephens, L.; Hawkins, P.; Barrett, J. C.; Abinun, M.; Clatworthy, M.; Durandy, A.; Doffinger, R.; Chilvers, E. R.; Cant, A. J.; Kumararatne, D.; Okkenhaug, K.; Williams, R. L.; Condliffe, A.; Nejentsev, S., Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Science 2013, 342 (6160), 866-71.

11. Goodall, J. C^#.; Wu, C^#.; Zhang, Y.; McNeill, L.; Ellis, L.; Saudek, V.; Gaston, J. S., Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Proc Natl Acad Sci U S A 2010, 107 (41), 17698-703.

发表的文章：

1. Zhang, L. C.; Liu, Y. N.; La, X. Q.; Li, S. T.; Wen, L. N.; Liu, T.; Li, H. Q.; Li, A. P.; Wu, H.; Wu, C. X.; Li, Z. Y., The bound polyphenols of foxtail millet (Setaria italica) inner shell inhibit breast cancer by promoting lipid accumulation-induced autophagic death. Food Chem Toxicol 2023, 177, 113855.

2. Xiong, Q.; Sun, H.; Xing, W.; Li, X.; Chen, G.; Zhao, Z.; Wu, C.; Li, P., WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism. Free Radic Biol Med 2023, 201, 89-97.

3. Wang, P. H.; Nawal Bahoussi, A.; Tariq Shah, P.; Guo, Y. Y.; Wu, C.; Xing, L., Genetic comparison of transmissible gastroenteritis coronaviruses. Front Vet Sci 2023, 10, 1146648.

4. Tufail, M.; Wu, C., Wnt3a is a promising target in colorectal cancer. Med Oncol 2023, 40 (3), 86.

5. Tufail, M.; Wu, C., SRPKs: a promising therapeutic target in cancer. Clin Exp Med 2023.

6. Tufail, M.; Wu, C., Exploring the Burden of Cancer in Pakistan: An Analysis of 2019 Data. J Epidemiol Glob Health 2023.

7. Tian, J.; Zhang, L.; La, X.; Fan, X.; Li, A.; Wu, C.; An, Y.; Yan, S.; Dong, X.; Wu, H.; Li, Z., Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism. Cell Signal 2023, 108, 110719.

8. Shah, P. T.; Wang, J.; Liu, Y.; Hussain, B.; Ma, Z. H.; Wu, C.; Xing, L., The phylogenetic and phylogeographic landscape of the beak and feather disease virus, 1996-2022. Infect Genet Evol 2023, 112, 105442.

9. Shah, P. T.; Bahoussi, A. N.; Yang, C.; Yao, G.; Dong, L.; Wu, C.; Xing, L., Genetic Characteristics and Phylogeographic Dynamics of Lagoviruses, 1988-2021. Viruses 2023, 15 (4).

10. Shah, P. T.; Bahoussi, A. N.; Cui, X.; Shabir, S.; Wu, C.; Xing, L., Genetic diversity, distribution, and evolution of chicken anemia virus: A comparative genomic and phylogenetic analysis. Front Microbiol 2023, 14, 1145225.

11. Ma, Z. H.; Nawal Bahoussi, A.; Tariq Shah, P.; Guo, Y. Y.; Dong, L.; Wu, C.; Xing, L., Phylogeographic dynamics and molecular characteristics of Enterovirus 71 in China. Front Microbiol 2023, 14, 1182382.

12. Liu, Y.; Zhu, D.; Liu, J.; Sun, X.; Gao, F.; Duan, H.; Dong, L.; Wang, X.; Wu, C., Pediococcus pentosaceus PR-1 modulates high-fat-died-induced alterations in gut microbiota, inflammation, and lipid metabolism in zebrafish. Front Nutr 2023, 10, 1087703.

13. Liu, S.; Yang, B.; Hou, Y.; Cui, K.; Yang, X.; Li, X.; Chen, L.; Liu, S.; Zhang, Z.; Jia, Y.; Xie, Y.; Xue, Y.; Li, X.; Yan, B.; Wu, C.; Deng, W.; Qi, J.; Lu, D.; Gao, G. F.; Wang, P.; Shang, G., The mechanism of STING autoinhibition and activation. Mol Cell 2023, 83 (9), 1502-1518.e10.

14. Han, J.; Cui, X.; Yuan, T.; Yang, Z.; Liu, Y.; Ren, Y.; Wu, C.; Bian, Y., Plasma-derived exosomal let-7c-5p, miR-335-3p, and miR-652-3p as potential diagnostic biomarkers for stable coronary artery disease. Front Physiol 2023, 14, 1161612.

15. Feng, J.; Li, F.; Sun, L.; Dong, L.; Gao, L.; Wang, H.; Yan, L.; Wu, C., Characterization and genome analysis of phage vB_KpnS_SXFY507 against Klebsiella pneumoniae and efficacy assessment in Galleria mellonella larvae. Front Microbiol 2023, 14, 1081715.

16. Fan, X.; Zhang, L.; La, X.; Tian, J.; Israr, G.; Li, A.; Wu, C.; An, Y.; Li, S.; Dong, X.; Li, Z., Salvianolic acid A attenuates inflammation-mediated atherosclerosis by suppressing GRP78 secretion of endothelial cells. J Ethnopharmacol 2023, 308, 116219.

17. Bahoussi, A. N.; Shah, P. T.; Zhao, J. Q.; Wang, P. H.; Guo, Y. Y.; Wu, C.; Xing, L., Multiple potential recombination events among Newcastle disease virus genomes in China between 1946 and 2020. Front Vet Sci 2023, 10, 1136855.

18. Bahoussi, A. N.; Shah, P. T.; Guo, Y. Y.; Liu, Y.; Wu, C.; Xing, L., Evolutionary adaptation of bovine coronavirus (BCoV): Screening of natural recombinations across the complete genomes. J Basic Microbiol 2023, 63 (5), 519-529.

19. Zhang, Y.; Wang, X.; Li, Z.; Zhang, J.; Wang, Y.; Wu, C.; Chen, C.; Li, J.; Zhang, H., Brucella melitensis outer membrane protein 25 interacts with ferritin heavy polypeptide 1 in human trophoblast cells. Mol Med Rep 2022, 26 (1).

20. Zhang, H.; Huang, Z.; Lv, L.; Xin, Y.; Wang, Q.; Li, F.; Dong, L.; Wu, C.; Ingham, P. W.; Zhao, Z., A transgenic zebrafish for in vivo visualization of cilia. Open Biol 2022, 12 (8), 220104.

21. Yao, X.; Zhang, Z.; Mei, Q.; Li, S.; Xing, L.; Long, Y.; Zhang, D.; Wang, J.; Wang, X.; Xie, B.; Yang, B.; Gao, Y.; Wu, C.; Meng, Q., A highly sensitive bead-based flow cytometric competitive binding assay to detect SARS-CoV-2 neutralizing antibody activity. Front Immunol 2022, 13, 1041860.

22. Yang, B.; Jia, Y.; Meng, Y.; Xue, Y.; Liu, K.; Li, Y.; Liu, S.; Li, X.; Cui, K.; Shang, L.; Cheng, T.; Zhang, Z.; Hou, Y.; Yang, X.; Yan, H.; Duan, L.; Tong, Z.; Wu, C.; Liu, Z.; Gao, S.; Zhuo, S.; Huang, W.; Gao, G. F.; Qi, J.; Shang, G., SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry. Proc Natl Acad Sci U S A 2022, 119 (4).

23. Yaigoub, H.; Tirichen, H.; Xin, X.; Shi, S.; Wu, C.; Li, R.; Li, Y., Isolation of Viable Single Cells With High Yield and Purity Using a Small Amount of Human Kidney Tissue Biopsy. Front Cell Dev Biol 2022, 10, 822275.

24. Yaigoub, H.; Fath, N.; Tirichen, H.; Wu, C.; Li, R.; Li, Y., Bidirectional crosstalk between dysbiotic gut microbiota and systemic lupus erythematosus: What is new in therapeutic approaches? Clin Immunol 2022, 244, 109109.

25. Wen, D.; Cui, J.; Li, P.; Xiong, Q.; Chen, G.; Wu, C., Syndecan-4 assists Mycobacterium tuberculosis entry into lung epithelial cells by regulating the Cdc42, N-WASP, and Arp2/3 signaling pathways. Microbes Infect 2022, 24 (4), 104931.

26. Wang, L.; Li, J.; Xiong, Q.; Zhou, Y. A.; Li, P.; Wu, C., Case Report: A Missense Mutation in Dyskeratosis Congenita 1 Leads to a Benign Form of Dyskeratosis Congenita Syndrome With the Mucocutaneous Triad. Front Pediatr 2022, 10, 834268.

27. Tufail, M.; Wu, C., Targeting the IGF-1R in prostate and colorectal cancer: reasons behind trial failure and future directions. Ther Deliv 2022, 13 (3), 167-186.

28. Tufail, M.; Wu, C., Psychological impact of COVID-19 pandemic on Parkinson's disease patients. Heliyon 2022, 8 (6), e09604.

29. Tufail, M.; Wu, C., RANK pathway in cancer: underlying resistance and therapeutic approaches. J Chemother 2022, 1-14.

30. Tufail, M.; Cui, J.; Wu, C., Breast cancer: molecular mechanisms of underlying resistance and therapeutic approaches. Am J Cancer Res 2022, 12 (7), 2920-2949.

31. Shah, P. T.; Tufail, M.; Wu, C.; Xing, L., THP-1 cell line model for tuberculosis: A platform for in vitro macrophage manipulation. Tuberculosis (Edinb) 2022, 136, 102243.

32. Ma, Y.; Sun, W.; Zhao, L.; Yao, M.; Wu, C.; Su, P.; Yang, L.; Wang, G., Generation of an mESC model with a human hemophilia B nonsense mutation via CRISPR/Cas9 technology. Stem Cell Res Ther 2022, 13 (1), 353.

33. Liu, Y.; Sun, X.; Zhang, J.; Gao, F.; Yu, L.; Dong, L.; Zhang, G.; Wu, C., Isolation and characterisation of Pulsatilla Radix-utilising bacteria Pediococcus pentosaceus PR-1 from human faeces. FEMS Microbiol Lett 2022, 369 (1).

34. Liu, Y.; Bahoussi, A. N.; Wang, P. H.; Wu, C.; Xing, L., Complete genome sequences of classical swine fever virus: Phylogenetic and evolutionary analyses. Front Microbiol 2022, 13, 1021734.

35. Li, P.; Wu, Y.; Wu, H.; Xiong, Q.; Zhao, N.; Chen, G.; Wu, C.; Xiao, H., Functional Characterization of FH Mutation c.557G>A Underlies Uterine Leiomyomas. Int J Mol Sci 2022, 23 (3).

36. Li, P.; Lan, W.; Li, J.; Zhang, Y.; Xiong, Q.; Ye, J.; Wu, C.; Xiao, H., Identification and Functional Evaluation of a Novel TBX4 Mutation Underlies Small Patella Syndrome. Int J Mol Sci 2022, 23 (4).

37. Li, J.; Gao, Z.; Chen, J.; Cheng, R.; Niu, J.; Zhang, J.; Yang, Y.; Yuan, X.; Xia, J.; Mao, G.; Liu, H.; Dong, Y.; Wu, C., Development of a panel of three multiplex allele-specific qRT-PCR assays for quick differentiation of recombinant variants and Omicron subvariants of SARS-CoV-2. Front Cell Infect Microbiol 2022, 12, 953027.

38. Hussain, B.; Xie, Y.; Jabeen, U.; Lu, D.; Yang, B.; Wu, C.; Shang, G., Activation of STING Based on Its Structural Features. Front Immunol 2022, 13, 808607.

39. Cui, X.; Yuan, T.; Ning, P.; Han, J.; Liu, Y.; Feng, J.; Lian, F.; Hao, M.; Dong, L.; Hao, J.; Xing, L.; Wu, C., Polymorphisms in the ASAP1 and SP110 Genes and Its Association with the Susceptibility to Pulmonary Tuberculosis in a Mongolian Population. J Immunol Res 2022, 2022, 2713869.

40. Cheng, T. Y.; Liu, Y. J.; Yan, H.; Xi, Y. B.; Duan, L. Q.; Wang, Y.; Zhang, T. T.; Gu, Y. M.; Wang, X. D.; Wu, C. X.; Gao, S., Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of Tumor Cells via ERK1/2. Cells 2022, 11 (24).

41. Bahoussi, A. N.; Wang, P. H.; Shah, P. T.; Bu, H.; Wu, C.; Xing, L., Evolutionary plasticity of zoonotic porcine Deltacoronavirus (PDCoV): genetic characteristics and geographic distribution. BMC Vet Res 2022, 18 (1), 444.

42. Bahoussi, A. N.; Wang, P. H.; Ma, Z. H.; Rani, N.; Wu, C.; Xing, L., Identification of novel recombinants and proposed standard reference genomes for phylogenetic classification of canine parvovirus-2 (CPV-2): Comprehensive analysis revealing global evolutionary trait. Front Vet Sci 2022, 9, 1030522.

43. Bahoussi, A. N.; Wang, P. H.; Guo, Y. Y.; Rabbani, N.; Wu, C.; Xing, L., Global Distribution and Natural Recombination of Hepatitis D Virus: Implication of Kyrgyzstan Emerging HDVs in the Clinical Outcomes. Viruses 2022, 14 (7).

44. Bahoussi, A. N.; Guo, Y. Y.; Wang, P. H.; Dahdouh, A.; Wu, C.; Xing, L., Genomic characteristics and recombination patterns of swine hepatitis E virus in China. Transbound Emerg Dis 2022, 69 (5), e3273-e3281.

45. Bahoussi, A. N.; Guo, Y. Y.; Shi, R. Z.; Wang, P. H.; Li, Y. Q.; Wu, C. X.; Xing, L., Genetic Characteristics of Porcine Hemagglutinating Encephalomyelitis Coronavirus: Identification of Naturally Occurring Mutations Between 1970 and 2015. Front Microbiol 2022, 13, 860851.

46. Zhao, N.; Yang, Y.; Li, P.; Xiong, Q.; Xiao, H.; Wu, C., Identification of Two Novel Compound Heterozygous EIF2AK3 Mutations Underlying Wolcott-Rallison Syndrome in a Chinese Family. Front Pediatr 2021, 9, 679646.

47. Zhao, N.; Wu, H.; Li, P.; Wang, Y.; Dong, L.; Xiao, H.; Wu, C., A novel pathogenic splice site variation in STK11 gene results in Peutz-Jeghers syndrome. Mol Genet Genomic Med 2021, 9 (8), e1729.

48. Zhang, Y.; Xiao, H.; Xiong, Q.; Wu, C.; Li, P., Two Novel Hydroxymethylbilane Synthase Splicing Mutations Predispose to Acute Intermittent Porphyria. Int J Mol Sci 2021, 22 (20).

49. Zhang, S. S.; Dong, L.; Wang, G. M.; Tian, Y.; Ye, X. F.; Zhao, Y.; Liu, Z. Y.; Zhai, J. Y.; Zhao, Z. L.; Wang, J. H.; Zhang, H. M.; Li, X. L.; Wu, C. X.; Yang, C. T.; Yang, L. J.; Du, H. X.; Wang, H.; Ge, Q. G.; Xiu, D. R.; Shen, N., Progressive liver injury and increased mortality risk in COVID-19 patients: A retrospective cohort study in China. World J Gastroenterol 2021, 27 (9), 835-853.

50. Yao, M.; Su, P.; Li, Z.; Cui, X.; Yang, Q.; Xing, X.; Lei, Y.; Lian, M.; Ren, T.; Wang, X.; Zheng, Y.; Wu, C., Knockout of Dip2c in murine ES cell line IBMSe001-B-1 by CRISPR/Cas9 genome editing technology. Stem Cell Res 2021, 53, 102236.

51. Yang, C.; Ma, X.; Wu, J.; Han, J.; Zheng, Z.; Duan, H.; Liu, Q.; Wu, C.; Dong, Y.; Dong, L., Low serum calcium and phosphorus and their clinical performance in detecting COVID-19 patients. J Med Virol 2021, 93 (3), 1639-1651.

52. Xiong, Q.; Song, N.; Li, P.; Fischer, S.; Konertz, R.; Wagle, P.; Glöckner, G.; Wu, C.; Eichinger, L., RNA(seq) and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16. BMC Genomics 2021, 22 (1), 444.

53. Xiong, Q.; Song, N.; Li, P.; Fischer, S.; Konertz, R.; Wagle, P.; Glöckner, G.; Wu, C.; Eichinger, L., Correction to: RNA(seq) and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16. BMC Genomics 2021, 22 (1), 555.

54. Xiong, Q.; Li, X.; Li, W.; Chen, G.; Xiao, H.; Li, P.; Wu, C., WDR45 Mutation Impairs the Autophagic Degradation of Transferrin Receptor and Promotes Ferroptosis. Front Mol Biosci 2021, 8, 645831.

55. Wang, L.; Xiong, Q.; Li, P.; Chen, G.; Tariq, N.; Wu, C., The negative charge of the 343 site is essential for maintaining physiological functions of CXCR4. BMC Mol Cell Biol 2021, 22 (1), 8.

56. Tirichen, H.; Yaigoub, H.; Xu, W.; Wu, C.; Li, R.; Li, Y., Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress. Front Physiol 2021, 12, 627837.

57. Meng, Q.; Wang, Y.; Long, Y.; Yue, A.; Mecklenburg, M.; Tian, S.; Fu, Y.; Yao, X.; Liu, J.; Song, D.; Wu, C.; Xie, B., Rapid Detection of Multiple Classes of β-Lactam Antibiotics in Blood Using an NDM-1 Biosensing Assay. Antibiotics (Basel) 2021, 10 (9).

58. Meng, Q.; Liu, S.; Meng, J.; Feng, J.; Mecklenburg, M.; Zhu, L.; Zhou, L.; Bülow, L.; Liu, J.; Song, D.; Wu, C.; Xie, B., Rapid personalized AMR diagnostics using two-dimensional antibiotic resistance profiling strategy employing a thermometric NDM-1 biosensor. Biosens Bioelectron 2021, 193, 113526.

59. Meng, Q.; Fu, Y.; Li, S.; Yan, Y.; Duan, D.; Anthony, D. D.; Zhu, Y.; Wu, X.; Qian, F.; Wu, C., Rapid, sensitive and cost-effective determination of immune checkpoint inhibitor activity using a magnetic bead-based binding assay. J Immunol Methods 2021, 498, 113134.

60. Liu, Y.; Wang, J.; Wu, C., Microbiota and Tuberculosis: A Potential Role of Probiotics, and Postbiotics. Front Nutr 2021, 8, 626254.

61. Liu, Y.; Wang, J.; Wu, C., Modulation of Gut Microbiota and Immune System by Probiotics, Pre-biotics, and Post-biotics. Front Nutr 2021, 8, 634897.

62. Han, J.; Ning, P.; Ge, A.; Ma, X.; Burton, J. A.; Yang, C.; Cui, X.; Wu, C.; Hao, J.; Dong, L., Corrigendum to "Association of polymorphisms of innate immunity-related genes and tuberculosis susceptibility in Mongolian population" [Hum. Immunol. 82(4) (2021) 232-239]. Hum Immunol 2021, 82 (9), 712.

63. Han, J.; Ning, P.; Ge, A.; Ma, X.; Alexander Burton, J.; Yang, C.; Cui, X.; Wu, C.; Hao, J.; Dong, L., Association of polymorphisms of innate immunity-related genes and tuberculosis susceptibility in Mongolian population. Hum Immunol 2021, 82 (4), 232-239.

64. Feng, J.; Gao, L.; Li, L.; Zhang, Z.; Wu, C.; Li, F.; Tong, Y., Characterization and genome analysis of novel Klebsiella phage BUCT556A with lytic activity against carbapenemase-producing Klebsiella pneumoniae. Virus Res 2021, 303, 198506.

65. Cui, J.; Chen, G.; Zhao, Z.; Wang, L.; Wen, D.; Xing, L.; Wu, C., ASAP1 regulates the uptake of Mycobacterium tuberculosis H37Ra in THP1-derived macrophages by remodeling actin cytoskeleton. Tuberculosis (Edinb) 2021, 129, 102090.

66. Chen, G.; Yang, Z.; Wen, D.; Guo, J.; Xiong, Q.; Li, P.; Zhao, L.; Wang, J.; Wu, C.; Dong, L., Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis. Immun Inflamm Dis 2021, 9 (3), 959-970.

67. Zhao, N.; Wang, J.; Xiao, H.; Wu, C., [Clinical and genetic characteristics of Chinese patients with Waardenburg syndrome]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020, 37 (10), 1186-1190.

68. Yao, M.; Yang, Q.; Lian, M.; Su, P.; Cui, X.; Ren, T.; Wang, X.; Wu, C.; Zheng, Y., Generation of Dip2a homozygous knockout murine ES cell line IBMSe001-A-1 via CRISPR/Cas9 technology. Stem Cell Res 2020, 45, 101778.

69. Wang, M.; Li, P.; Wang, H.; Dong, L.; Wu, C.; Zhao, Z., Identification and spatiotemporal expression of gpr161 genes in zebrafish. Gene 2020, 730, 144303.

70. Li, J.; Li, Z.; Cui, X.; Wu, C., Bayesian phylodynamic inference on the temporal evolution and global transmission of SARS-CoV-2. J Infect 2020, 81 (2), 318-356.

71. Cui, X.; Zhang, S.; Zhang, Q.; Guo, X.; Wu, C.; Yao, M.; Sun, D., Comprehensive MicroRNA Expression Profile of the Mammary Gland in Lactating Dairy Cows With Extremely Different Milk Protein and Fat Percentages. Front Genet 2020, 11, 548268.

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