崔晓钢   博士
	讲师   硕士生导师
	Email：xgcui@sxu.edu.cn

 

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教育经历：

2006.09-2010.07 华中农业大学 学士

2010.09-2015.07 中国农业大学 硕博连读 博士

工作经历：

2016.06-2017.07 美国佐治亚大学（University of Georgia）博士后研究

2018.01-至今 山西大学生物医学研究院

主要研究方向：

1）基于二代测序技术及蛋白组学鉴定奶牛乳成分标志物

2）基于外泌体二代测序技术筛选结核病标志物及鉴定

3）结核病易感基因相关SNP调控分子机制研究（斑马鱼模型）

招生专业：

1、学术型硕士：遗传学、生物化学与分子生物学、微生物学

2、专业型硕士：生物与医药（生物工程、食品工程）

      

主持项目：

1. 企业合作项目，稷山板枣功能性产品的开发，2021.12 -2024.12，在研，主持

2. 企业合作项目，灵芝三贴酸功能性产品的开发，2021.12-2024.12，在研，主持

3. 企业合作项目，乳品质鉴定试剂盒的开发，2021.11-2024.11，在研，主持

4. 企业合作项目，生物多样性GAP分析软件的开发，2019-09至2021-08，在研，主持

5. 山西省高等学校科技创新项目，奶牛乳脂性状关键基因TRIB3及miRNA 对泌乳调控机制研究，2019.07-2021.07，在研，主持

6. 山西省自然科学基金青年基金，基于高通量测序技术筛选奶牛乳成分相关miRNA并进行功能验证，2018.12-2020.12，在研，主持

代表性论文：

1. Han J†, Cui X†（同等一作）, Yuan T, Yang Z, Liu Y, Ren Y, Wu C, Bian Y*. Plasma-derived exosomal let-7c-5p, miR-335-3p, and miR-652-3p as potential diagnostic biomarkers for stable coronary artery disease. Front Physiol. 2023; 14:1161612.

2. Cui X, Li C, Wei Z, Meng H, Zhang F, Liu Y, Wu C, Yang S*. DDIT3 Governs Milk Production Traits by Targeting IL-6 to Induce Apoptosis in Dairy Cattle. Agriculture. 2023; 13(1):117.

3. Cui X, Yuan T, Ning P, Han J, Liu Y, Feng J, Lian F, Hao M, Dong L, Hao J, Xing L*, Wu C*. Polymorphisms in the ASAP1 and SP110 Genes and Its Association with the Susceptibility to Pulmonary Tuberculosis in a Mongolian Population. J Immunol Res. 2022; 2022:2713869.

4. Cui X, Yuan T, Fang Z, Feng J, Wu C*. Bta-miR-125a Regulates Milk-Fat Synthesis by Targeting SAA1 mRNA in Bovine Mammary Epithelial Cells. Agriculture. 2022; 12(3):344.

5. Cui X, Zhang S, Zhang Q, Guo X, Wu C, Yao M, Sun D*. Comprehensive microRNA expression profile of the mammary gland in lactating dairy cows with extremely different milk protein and fat percentages. Front Genet. 2020; 11:548268.

6. Cui X, Marshall B, Shi N, Chen SY, Rekaya R, Liu HX*. RNA-Seq analysis on chicken taste sensory organs: An ideal system to study organogenesis. Sci Rep. 2017;7(1):9131.

7. Cui X, Hou Y, Yang S, Xie Y, Zhang S, Zhang Y, Zhang Q, Lu X, Liu GE, Sun D*. Transcriptional profiling of mammary gland in Holstein cows with extremely different milk protein and fat percentage using RNA sequencing. BMC Genomics. 2014; 15:226.

8. Li F, Li L, Zhang Y, Bai S, Sun L, Guan J, Zhang W, Cui X*, Feng J*, Tong Y*. Isolation and characterization of the novel bacteriophage vB_SmaS_BUCT626 against Stenotrophomonas maltophilia. Virus Genes. 2022;58(5):458-466.

参与发表的论文（按发表时间顺序）：

1. Shah PT, Bahoussi AN, Cui X, Shabir S, Wu C, Xing L*. Genetic diversity, distribution, and evolution of chicken anemia virus: A comparative genomic and phylogenetic analysis. Front Microbiol. 2023; 14:1145225.

2. Liu G, Wang Z, Cui X, Yang S*. Component analysis of Xylaria sp. L1 sporocarps after solid-state fermentation by okara and its safety evaluation in mice and rats. Nat Prod Res. 2023; 37(5):852-856.

3. Yao M, Su P, Li Z, Cui X, Yang Q, Xing X, Lei Y, Lian M, Ren T, Wang X, Zheng Y*, Wu C*. Knockout of Dip2c in murine ES cell line IBMSe001-B-1 by CRISPR/Cas9 genome editing technology. Stem Cell Res. 2021; 53:102236.

4. Han J, Ning P, Ge A, Ma X, Alexander Burton J, Yang C, Cui X, Wu C*, Hao J, Dong L. Association of polymorphisms of innate immunity-related genes and tuberculosis susceptibility in Mongolian population. Hum Immunol. 2021; 82(4):232-239.

5. Yu W, Wang Z, Marshall B, Yoshida Y, Patel R, Cui X, Ball R, Yin L, Kawabata F, Tabata S, Chen W, Kelsh RN, Lauderdale JD, Liu HX*. Taste buds are not derived from neural crest in mouse, chicken, and zebrafish. Dev Biol. 2021; 471:76-88.

6. Yao M, Yang Q, Lian M, Su P, Cui X, Ren T, Wang X, Wu C, Zheng Y*. Generation of Dip2a homozygous knockout murine ES cell line IBMSe001-A-1 via CRISPR/Cas9 technology. Stem Cell Res. 2020; 45:101778.

7. Li J, Li Z, Cui X, Wu C*. Bayesian phylodynamic inference on the temporal evolution and global transmission of SARS-CoV-2. J Infect. 2020;81(2):318-356.

8. Ma F, Zhi C, Wang M, Li T, Khan SA, Ma Z, Jing Z, Bo C, Zhou Q, Xia S, Huang S, Huang S, Zhang Z, Jia H, Cui X, Yao M, Ji T*. Dysregulated NF-κB signal promotes the hub gene PCLAF expression to facilitate nasopharyngeal carcinoma proliferation and metastasis. Biomed Pharmacother. 2020; 125:109905.

9. Kramer N, Chen G, Ishan M, Cui X, Liu HX*. Early taste buds are from Shh+ epithelial cells of tongue primordium in distinction from mature taste bud cells which arise from surrounding tissue compartments. Biochem Biophys Res Commun. 2019; 515(1):149-155.

10. Fan Y, Wang P, Fu W, Dong T, Qi C, Liu L, Guo G, Li C, Cui X, Zhang S, Zhang Q, Zhang Y, Sun D*. Genome-wide association study for pigmentation traits in Chinese Holstein population. Anim Genet. 2014;45(5):740-4.

11. Xie Y, Yang S, Cui X, Jiang L, Zhang S, Zhang Q, Zhang Y, Sun D*. Identification and expression pattern of two novel alternative splicing variants of EEF1D gene of dairy cattle. Gene. 2014; 534(2):189-96.

12. 宁鹏媛;董丽;郝金奇;崔晓钢;杨彩婷;王爱欣;郝明媛;余艳琴;吴长新*; 蒙汉民族ASAP1、NRAMP1、SP110基因表达水平与结核病易感性关联分析. 中国动物传染病学报.2020.