陈广信 博士
	副教授 硕士研究生导师
	Email：chengx@sxu.edu.cn

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教育和工作经历：

2008.09-2012.06  河北北方学院 学士

2012.09-2015.06  广东海洋大学 硕士

2015.09-2018.06  吉林大学 博士

2018.07-至今 山西大学 讲师

2021.10-至今 中国农业大学 博士后

2024.01-至今 山西大学  副教授

 

主要研究方向：

       目前主要开展关键分子和细胞（目前包括BTNL2，NRF2，AHR，NLPR6，NLRP3，GPR120，γδ T淋巴细胞）在肠道氧化应激、肠道炎性损伤中作用及机制研究。

 目前的研究主要方向：

1. 免疫分子在肠道炎性损伤的作用及机制

2. 靶向免疫分子探索相关营养素

主持项目：

1. 山西省科技厅，中央引导地方科技发展资金项目，YDZJSX20231A005，BTNL2抑制结核分枝杆菌对肠道组织感染的作用机制研究，2023.02-2026.02，40万元；

2. 国家自然基金青年基金，BTNL2抑制γδT淋巴细胞活化介导IUGR仔猪肠道炎性损伤的机制及其营养调控，32202698，2023.01-2025.12，30万元；

3. 中国博士后科学基金第71批面上项目，靶向调控BTNL2抑制IUGR仔猪肠道炎性损伤的营养素筛选，2022M710476，2022.07-2023.10，8万元；

4. 山西省自然科学基金青年基金，SDC4对M. tuberculosis 侵入肺上皮细胞的影响及机制研究，201901D211142，2019.09-2022.09，3万元；

5. 山西省高等学校科技创新项目，ASAP1 抑制Mtb 从巨噬细胞逃逸的机理研究，2019L0035，2020.1-2021.12，2万元；

6. 中央提升陈广信人才事业启动经费，2019.1-2022.12，23万元。

代表性论文：

1. Guangxin Chen^#, Da Wen^#, Lin Shen, Yazhi Feng, Qiuhong Xiong, Ping Li, Zhonghua Zhao*. Cepharanthine exerts antioxidant and anti-Inflammatory effects in lipopolysaccharide (LPS)-induced macrophages and DSS-induced colitis mice. Molecules, 2023, 28. (IF=4.6)

2. Guangxin Chen, Ziyue Yang, Da Wen, Ping Li, Qiuhong Xiong, Changxin Wu*. (2023) Oridonin inhibits Mycobacterium marinum infection induced oxidative stress in vitro and in vivo. Pathogens, 12, (6). (IF=3.7)

3. Yang Liu, Yuxin Lei, Jianwei Li, Yuze Ma, Xueyin Wang, Fanhua Meng, Yujing Wu, Na Wang, Jing Liang, Caiquan Zhao, Yang Yang, Guangxin Chen*, Shuixing Yu*.G protein-coupled receptor 120 mediates host defense against clostridium perfringens infection through regulating NOD-like receptor family pyrin domain-containing 3 inflammasome activation. Journal of Agricultural and Food Chemistry, 2023,71, (18), 7119-7130. (IF=6.1)列通讯作者.

4. Da Wen, Jia Cui, Ping Li, Qiuhong Xiong, Guangxin Chen*, Changxin Wu*. Syndecan-4 assists Mycobacterium tuberculosis entry into lung epithelial cells by regulating the Cdc42, N-WASP, and Arp2/3 signaling pathways. Microbes and Infection, 2022, 24(4): 104931. (IF=9.57)，并列通讯作者.

5. Guangxin Chen^#, Ziyue Yang^#, Da Wen^#, Jian Guo, Qiuhong Xiong, Ping Li, Liping Zhao, Junping Wang*, Changxin Wu*, Lina Dong*. Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis. Immunity inflammation and disease, 2021, 9 (3), 959-970. (IF=2.49)

6. Guangxin Chen, Xin Ran, Bai Li, Yuhang Li, Dewei He, Bingxu Huang, Shoupeng Fu, Juxiong Liu, Wei Wang. Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model. EBioMedicine, 2018, 30. (SCI, IF=11.2). ESI高被引，被引162次.

7. Guangxin Chen, Bingxu Huang, Shoupeng Fu, Bai Li, Xin Ran, Dewei He, Liqiang Jiang, Yuhang Li, Liwei Xie, Juxiong Liu and Wei Wang. G Protein-Coupled Receptor 1 109A and Host Microbiota Modulate Intestinal Epithelial Integrity during Sepsis. Frontiers in Immunology. (IF=8.78).

8. Guangxin Chen, Shoupeng Fu, Wenqian Feng, Bingxu Huang, Shiyao Xu, Wei Wang and Juxiong Liu. AMP010014A09 in Sus Scrofa Encodes an Analog of G Protein-Coupled Receptor 109A, Which Mediates the Anti-Inflammatory Effects of Beta-Hydroxybutyric Acid. Cellular physiology and biochemistry, 2017, 42, 1420-1430. (SCI, IF=5.104).

9. Guangxin Chen, Juxiong Liu, Liqiang Jiang, Xin Ran, Dewei He, Yuhang Li, Bingxu Huang, Wei Wang, Shoupeng Fu. Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson's Disease in Rats. International journal of molecular sciences 2017, 19, (1). (IF=6.2).

10. Guangxin Chen, Juxiong Liu, Bingxu Huang, Xin Ran, Liqiang Jiang, Yuhang Li, Wei Wang, Shoupeng Fu. Peiminine protects dopaminergic neurons from inflammation-induced cell death by inhibiting the ERK1/2 and NF-κB signalling pathways. International Journal of Molecular Sciences 2018, 19(3). (IF=6.2).

11. Guangxin Chen, Zhenhua Gao, Wenhui Chu, Zan Cao, Chunyi Li, Haiping ZhaoZhao. Effects of Chromium Picolinate on Fat Deposition, Activity and Genetic Expression of Lipid Metabolism-Related Enzymes in 21 Day Old Ross Broilers. Asian-Australasian Journal of Animal Science.2017. (SCI, IF=2.69).

12. Wenqian Feng^#, Yancheng Wu^#, Guangxin Chen^#, Shoupeng Fu, Bai Li, Bingxu Huang, Dali Wang, Wei Wang and Juxiong Liu. Sodium Butyrate Attenuates Diarrhea in Weaned Piglets and Promotes Tight Junction Protein Expression in Colon in a GPR109A-Dependent Manner. Cellular physiology and biochemistry, 2018; 47:1617-1629. (SCI, IF=5.104). 并列第一作者

13. Xin Ran^#, Yuhang Li^#, Guangxin Chen^#, Shoupeng Fu, Dewei He, Bingxu Huang, Libin Wei, Yuanqing Lin, Yingcheng Guo and Guiqiu Hu. Farrerol Ameliorates TNBS-Induced Colonic Inflammation by Inhibiting ERK1/2, JNK1/2, and NF-κB Signaling Pathway. International Journal of Molecular Sciences 2018, 19(7). (IF=6.2). 并列第一作者.