邢力 博士
	教授 博士生导师
	Email：LL638@email.sxu.edu.cn

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教育背景

扬州大学获硕士学位。

中国科学院上海生物化学和细胞生物学研究所获博士学位。

哈佛大学医学院微生物与免疫学系博士后。

 

主要研究方向

1. 结核分枝杆菌感染诱导的固有免疫反应分子机制。

2. 病毒感染引起的神经退行性疾病的病理分子机制。

3. 病毒的分子进化和流行特征。

 

注：本实验组招聘博士后，随时受理入站申请。应聘人员可直接联系咨询。

 

招生专业

博士：微生物学，动物学，遗传学

硕士：微生物学，

专业硕士：生物技术和工程

  

研究生和博士后

24级：王伊犁，姚蕊，张慧雯

23级：褚夏楠

22级：马梓慧，王艳, Nahla Hassaan (博士后)

21级：王霈桦，郭艳艳，Roua Ahmed (博士生)，Muhammad Sikandar (博士生)

20级：李亚倩，师瑞珠

19级：郭凡，Tariq Shan (博士生), Amina Bahoussi (博士生)

 

论文（标*为通讯作者）

 

2025

 The entry of Zika virus into the cells and its implication for antiviral therapeutic. Hassaan NA, Xing L*. Vector Borne Zoonotic Dis.  2025. (Accept)

The immunomodulatory effects of Mesenchymal stem cells on THP-1-derived macrophages against Mycobacterium tuberculosis H37Ra infection. Yang Q, Zhou Y, Farooq W, Liu Q, Duan J, Xing L, Wu C*, Dong L*. Tuberculosis (Edinb). 2025 Jan;150: 102593.

Transport of miR-766-3p to A549 cells by plasma-derived exosomes and its effect on intracellular survival of Mycobacterium tuberculosis by regulating NRAMP1 expression in A549 cells. Cui X, Zhang F, Meng H, Yuan T, Li M, Yuan D, Fan X, Jia X, Wang Q*, Xing L*, Wu C*. Microbiol Res. 2025 Jan; 290:127943.

  

2024

Ibuprofen modulates macrophage polarization by downregulating poly (ADP-ribose) polymerase 1. Wang PH, Wang Y, Guo YY, Ma ZH, Wu C, Xing L*. Int Immunopharmacol. 2024 Dec 25; 143(Pt 3):113502.

The mechanisms of Zika virus-induced neuropathogenesis. Hassaan NA, Xing L*. Braz J Microbiol. 2024 Dec;55(4):3933-3943. Review.

The roles of rabies virus structural proteins in immune evasion and implications for vaccine development. Wang PH, Xing L*. Can J Microbiol. 2024 Nov 1;70(11):461-469. Review.

Evolutionary History and Genetic Variation of Zika Virus: Connection Between Thailand Zika Viruses and Global Outbreaks Strains. Bahoussi AN, Shah PT, Liu Y, Guo YY, Bu H, Wu C, Xing L*. Vector Borne Zoonotic Dis. 2024 Feb;24(2):122-128.

Genotyping and phylogeographic dynamics of coxsackievirus A16. Chu XN, Shah PT, Ma ZH, Wang Y, Xing L*. Heliyon. 2024 Sep 21;10(19): e38248.

Genetic diversity and phylogeographic dynamics of avihepadnavirus: a comprehensive full-length genomic view. Sikandar M, Shah PT, Xing L*. Front Vet Sci. 2024 May 2;11: 1385033.

Reply to Abrantes et al. Recombination-Based Perspectives on Lagovirus Classification, Phylogenetic Patterns, and Evolutionary Dynamics. Comment on "Shah et al. Genetic Characteristics and Phylogeographic Dynamics of Lagoviruses, 1988-2021 ". Shah PT*, Xing L*. Viruses. 2024 Jun 7;16(6):928.

The biological mechanism and health effect of co-infection with multiple pathogens. Dong L, Xing L*. Front Cell Infect Microbiol. 2024 Jan 31; 14:1370067.

Diagnosis of a cystic lymphocyte-rich thymoma in a young cat. Zhang J, Xu W, Xu D, Wu C, Xing L*. Vet Res Forum. 2024;15(8):439-443.

 

2023

Loss of Dip2b leads to abnormal neural differentiation from mESCs. Yao M*, Pan Y, Ren T, Yang C, Lei Y, Xing X, Zhang L, Cui X, Zheng Y, Xing L, Wu C*. Stem Cell Res Ther. 2023 Sep 13;14(1):248.

Transcriptomic profiling of Dip2a in the neural differentiation of mouse embryonic stem cells. Yao M*, Zhang L, Teng X, Lei Y, Xing X, Ren T, Pan Y, Zhang L, Li Z, Lin J, Zheng Y, Xing L, Zhou J*, Wu C*. Comput Struct Biotechnol J. 2023 Dec 27;23: 700-710.

The phylogenetic and phylogeographic landscape of the beak and feather disease virus, 1996-2022. Shah PT, Wang J, Liu Y*, Hussain B, Ma ZH, Wu C, Xing L*. Infect Genet Evol. 2023 Aug;112: 105442.

Genetic comparison of transmissible gastroenteritis coronaviruses. Wang PH, Nawal Bahoussi A, Tariq Shah P, Guo YY, Wu C, Xing L*. Front Vet Sci. 2023 Apr 17;10: 1146648.

Genetic diversity, distribution, and evolution of chicken anemia virus: A comparative genomic and phylogenetic analysis. Shah PT, Bahoussi AN, Cui X, Shabir S, Wu C, Xing L*. Front Microbiol. 2023 Mar 9;14: 1145225.

Duck hepatitis a virus: Full-length genome-based phylogenetic and phylogeographic view during 1986-2020. Yang C, Shah PT, Bahoussi AN, Wu C, Wang L, Xing L*. Virus Res. 2023 Oct 15;336: 199216.

Meta-analysis of downregulated E-cadherin as a diagnostic biomarker for cervical cancer. Ma X, Ge A, Han J, Kang J, Zhang Y, Liu X, Xing L*, Liu X*, Dong L*. Arch Gynecol Obstet. 2023 Feb;307(2):331-341. Review.

Genetic characteristics and geographic distribution of rabies virus in China. Wang PH, Shah PT, Xing L*. Arch Virol. 2023 Dec 29;169(1):14.

Genetic Characteristics and Phylogeographic Dynamics of Lagoviruses, 1988-2021. Shah PT, Bahoussi AN, Yang C, Yao G, Dong L, Wu C, Xing L*. Viruses. 2023 Mar 23;15(4):815.

Genetic Characteristics and Phylogeographic Dynamics of Echovirus. Wang Y, Shah PT, Liu Y, Bahoussi AN, Xing L*. J Microbiol. 2023 Sep;61(9):865-877.

Phylogeographic dynamics and molecular characteristics of Enterovirus 71 in China. Ma ZH, Nawal Bahoussi A, Tariq Shah P, Guo YY, Dong L, Wu C, Xing L*. Front Microbiol. 2023 May 19;14: 1182382.

Multiple potential recombination events among Newcastle disease virus genomes in China between 1946 and 2020. Bahoussi AN, Shah PT, Zhao JQ, Wang PH, Guo YY, Wu C, Xing L*.

Front Vet Sci. 2023 May 3;10: 1136855.

Evolutionary adaptation of bovine coronavirus (BCoV): Screening of natural recombinations across the complete genomes. Bahoussi AN, Shah PT, Guo YY, Liu Y*, Wu C, Xing L*. J Basic Microbiol. 2023 May;63(5):519-529.

Characteristics of plasma exosomes in drug-resistant tuberculosis patients. Wu M, Yang Q, Yang C, Han J, Liu H, Qiao L, Duan H, Xing L, Liu Q, Dong L*, Wang Q*, Zuo L*. Tuberculosis (Edinb). 2023 Jul;141: 102359.

 

2022

Identification of novel recombinants and proposed standard reference genomes for phylogenetic classification of canine parvovirus-2 (CPV-2): Comprehensive analysis revealing global evolutionary trait. Bahoussi AN, Wang PH, Ma ZH, Rani N, Wu C, Xing L*. Front Vet Sci. 2022 Nov 15;9: 1030522.

THP-1 cell line model for tuberculosis: A platform for in vitro macrophage manipulation. Shah PT, Tufail M, Wu C, Xing L*. Tuberculosis (Edinb). 2022 Sep;136: 102243. Review.

Complete genome sequences of classical swine fever virus: Phylogenetic and evolutionary analyses. Liu Y, Bahoussi AN, Wang PH, Wu C, Xing L*. Front Microbiol. 2022 Sep 26;13: 1021734.

Genomic characteristics and recombination patterns of swine hepatitis E virus in China. Bahoussi AN, Guo YY, Wang PH, Dahdouh A, Wu C, Xing L*. Transbound Emerg Dis. 2022 Sep;69(5): e3273-e3281.

A highly sensitive bead-based flow cytometric competitive binding assay to detect SARS-CoV-2 neutralizing antibody activity. Yao X, Zhang Z, Mei Q, Li S, Xing L, Long Y, Zhang D, Wang J, Wang X, Xie B, Yang B, Gao Y, Wu C*, Meng Q*. Front Immunol. 2022 Nov 30;13: 1041860.

Global Distribution and Natural Recombination of Hepatitis D Virus: Implication of Kyrgyzstan Emerging HDVs in the Clinical Outcomes. Bahoussi AN, Wang PH, Guo YY, Rabbani N, Wu C, Xing L*. Viruses. 2022 Jul 2;14(7):1467.

Bovine viral diarrhea virus in China: A comparative genomic and phylogenetic analysis with complete genome sequences. Shah PT, Nawal Bahoussi A, Ahmad A, Sikandar M, Xing L*. Front Vet Sci. 2022 Sep 2;9: 992678.

Evolutionary plasticity of zoonotic porcine Deltacoronavirus (PDCoV): genetic characteristics and geographic distribution. Bahoussi AN, Wang PH, Shah PT, Bu H, Wu C*, Xing L*. BMC Vet Res. 2022 Dec 22;18(1):444.

Genetic Characteristics of Porcine Hemagglutinating Encephalomyelitis Coronavirus: Identification of Naturally Occurring Mutations Between 1970 and 2015. Bahoussi AN, Guo YY, Shi RZ, Wang PH, Li YQ, Wu CX, Xing L*. Front Microbiol. 2022 Mar 18;13: 860851.

Polymorphisms in the ASAP1 and SP110 Genes and Its Association with the Susceptibility to Pulmonary Tuberculosis in a Mongolian Population. Cui X, Yuan T, Ning P, Han J, Liu Y, Feng J, Lian F, Hao M, Dong L, Hao J, Xing L*, Wu C*. J Immunol Res. 2022 Sep 20;2022: 2713869.

 

2021-2020

Genetic drift of MERS-CoV in Saudi Arabia during 2012-2019. Pan YQ, Guo F, Bahoussi AN, Shi RZ, Li YQ, Xing L*. Zoonoses Public Health. 2021 Aug;68(5):527-532.

RNA helicase A as co-factor for DNA viruses during replication. Guo F, Xing L*. Virus Res. 2021 Jan 2;291: 198206. Review.

RNA Helicase A Regulates the Replication of RNA Viruses. Shi RZ, Pan YQ, Xing L*. Viruses. 2021 Feb 25;13(3):361. Review.

The Current View on the Helicase Activity of RNA Helicase A and Its Role in Gene Expression. Pan YQ, Xing L*. Curr Protein Pept Sci. 2021;22(1):29-40. Review.

The spike glycoprotein genes of porcine epidemic diarrhea viruses isolated in China. Wang PH, Li YQ, Pan YQ, Guo YY, Guo F, Shi RZ, Xing L*. Vet Res. 2021 Jun 15;52(1):87.

ASAP1 regulates the uptake of Mycobacterium tuberculosis H37Ra in THP1-derived macrophages by remodeling actin cytoskeleton. Cui J, Chen G, Zhao Z, Wang L, Wen D, Xing L*, Wu C*. Tuberculosis (Edinb). 2021 Jul;129: 102090.

The Characteristics of Spike Glycoprotein Gene of Swine Acute Diarrhea Syndrome Coronavirus Strain CH/FJWT/2018 Isolated in China. Guo YY, Wang PH, Pan YQ, Shi RZ, Li YQ, Guo F, Xing L*. Front Vet Sci. 2021 Jul 22;8: 687079.

Vaccination against the digestive enzyme Cathepsin B using a YS1646 Salmonella enterica Typhimurium vector provides almost complete protection against Schistosoma mansoni challenge in a mouse model. Hassan AS, Zelt NH, Perera DJ, Xing L, Ndao M, Ward BJ. PLoS Negl Trop Dis. 2021 Nov 4;15(11): e0009936.

Puzzling increase and decrease in COVID-19 cases in Pakistan. Shah PT, Xing L*. New Microbes New Infect. 2020 Nov;38: 100791.

A single nucleotide distinguishes the SARS-CoV-2 in the Wuhan outbreak in December 2019 from that in Beijing-Xinfadi in June 2020, China. Pan YQ, Bahoussi AN, Guo F, Xing L*. New Microbes New Infect. 2020 Dec 15;39: 100835.

 

专利

1、邢力; 潘元晴; 吴长新; 一种增强细菌中外源蛋白活性和表达的最小启动子, 2022-07-19, 中国, 5317357 (专利)

2、邢力; 潘元晴; 吴长新; 一种增强细菌中外源蛋白活性和表达的前导稳定元件, 2022-09-23, 中国, 5472069 (专利)