陈广信 博士
	副教授 硕士研究生导师
	Email：chengx@sxu.edu.cn

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研究方向

课题组聚焦于病原体感染性疾病的免疫病理学发病机制研究，同时开展肠道免疫研究。近5年主持国家自然科学基金青年项目、博士后科学基金面上项目、中央引导地方科技发展资金项目等。具体方向如下：

1、结核分枝杆菌蛋白与宿主蛋白互作：

主要探寻与宿主细胞焦亡相关的结核分枝杆菌蛋白，同时开展结核分枝杆菌蛋白与宿主蛋白相互作用方面研究。

2、肠道免疫

目前主要开展关键分子和细胞（目前包括BTNL2，NRF2，NLPR6，NLRP3，GPR120，γδ T淋巴细胞）在肠道氧化应激、肠道炎性损伤中作用及机制研究，并开展营养素靶向关键分子维持肠道稳态的研究。

招生专业

硕士研究生：遗传学、生物工程与技术

在读研究生

科研项目

1. 山西省科技厅，中央引导地方科技发展资金项目，YDZJSX20231A005，BTNL2抑制结核分枝杆菌对肠道组织感染的作用机制研究，2023.09-2026.09，40万元，主持；

2. 国家自然基金青年基金，BTNL2抑制γδT淋巴细胞活化介导IUGR仔猪肠道炎性损伤的机制及其营养调控，32202698，2023.01-2025.12，30万元，主持；

3. 中国博士后科学基金第71批面上项目，靶向调控BTNL2抑制IUGR仔猪肠道炎性损伤的营养素筛选，2022M710476，2022.07-2023.10，8万元，主持；

4. 山西省自然科学基金青年基金，SDC4对M. tuberculosis 侵入肺上皮细胞的影响及机制研究，201901D211142，2019.09-2022.09，3万元，主持；

5. 山西省高等学校科技创新项目，ASAP1 抑制Mtb 从巨噬细胞逃逸的机理研究，2019L0035，2020.1-2021.12，2万元，主持；

6. 中央提升陈广信人才事业启动经费，2019.1-2022.12，23万元，主持。

主要成果

1. Guangxin Chen^#, Lin Shen^#, Hong Hu, Yazhi Feng, Da Wen, Yiyao Liu, Huizhe Zhai, Wei Sun, Meifen Wang, Xinghua Lei, Ping Li, Qiuhong Xiong, Changxin Wu. (2024) Sulforaphane Inhibits Oxidative Stress and May Exert Anti-Pyroptotic Effects by Modulating NRF2/NLRP3 Signaling Pathway in Mycobacterium tuberculosis-Infected Macrophages. Microorganisms, 12(6):1191.

2. Guangxin Chen^#, Da Wen^#, Lin Shen, Yazhi Feng, Qiuhong Xiong, Ping Li, Zhonghua Zhao*. Cepharanthine exerts antioxidant and anti-Inflammatory effects in lipopolysaccharide (LPS)-induced macrophages and DSS-induced colitis mice. Molecules, 2023, 28.

3. Guangxin Chen, Ziyue Yang, Da Wen, Ping Li, Qiuhong Xiong, Changxin Wu*. (2023) Oridonin inhibits Mycobacterium marinum infection induced oxidative stress in vitro and in vivo. Pathogens, 12, (6).

4. Yang Liu, Yuxin Lei, Jianwei Li, Yuze Ma, Xueyin Wang, Fanhua Meng, Yujing Wu, Na Wang, Jing Liang, Caiquan Zhao, Yang Yang, Guangxin Chen*, Shuixing Yu*.G protein-coupled receptor 120 mediates host defense against clostridium perfringens infection through regulating NOD-like receptor family pyrin domain-containing 3 inflammasome activation. Journal of Agricultural and Food Chemistry, 2023,71, (18), 7119-7130. 并列通讯作者.

5. Da Wen, Jia Cui, Ping Li, Qiuhong Xiong, Guangxin Chen*, Changxin Wu*. Syndecan-4 assists Mycobacterium tuberculosis entry into lung epithelial cells by regulating the Cdc42, N-WASP, and Arp2/3 signaling pathways. Microbes and Infection, 2022, 24(4): 104931. 并列通讯作者.

6. Guangxin Chen^#, Ziyue Yang^#, Da Wen^#, Jian Guo, Qiuhong Xiong, Ping Li, Liping Zhao, Junping Wang*, Changxin Wu*, Lina Dong*. Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis. Immunity inflammation and disease, 2021, 9 (3), 959-970.

7. Guangxin Chen, Xin Ran, Bai Li, Yuhang Li, Dewei He, Bingxu Huang, Shoupeng Fu, Juxiong Liu, Wei Wang. Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model. EBioMedicine, 2018, 30.

8. Guangxin Chen, Bingxu Huang, Shoupeng Fu, Bai Li, Xin Ran, Dewei He, Liqiang Jiang, Yuhang Li, Liwei Xie, Juxiong Liu and Wei Wang. G Protein-Coupled Receptor 1 109A and Host Microbiota Modulate Intestinal Epithelial Integrity during Sepsis. Frontiers in Immunology.

9. Guangxin Chen, Shoupeng Fu, Wenqian Feng, Bingxu Huang, Shiyao Xu, Wei Wang and Juxiong Liu. AMP010014A09 in Sus Scrofa Encodes an Analog of G Protein-Coupled Receptor 109A, Which Mediates the Anti-Inflammatory Effects of Beta-Hydroxybutyric Acid. Cellular physiology and biochemistry, 2017, 42, 1420-1430.

10. Guangxin Chen, Juxiong Liu, Liqiang Jiang, Xin Ran, Dewei He, Yuhang Li, Bingxu Huang, Wei Wang, Shoupeng Fu. Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson's Disease in Rats. International journal of molecular sciences 2017, 19, (1).

11. Guangxin Chen, Juxiong Liu, Bingxu Huang, Xin Ran, Liqiang Jiang, Yuhang Li, Wei Wang, Shoupeng Fu. Peiminine protects dopaminergic neurons from inflammation-induced cell death by inhibiting the ERK1/2 and NF-κB signalling pathways. International Journal of Molecular Sciences 2018, 19(3).

12. Guangxin Chen, Zhenhua Gao, Wenhui Chu, Zan Cao, Chunyi Li, Haiping ZhaoZhao. Effects of Chromium Picolinate on Fat Deposition, Activity and Genetic Expression of Lipid Metabolism-Related Enzymes in 21 Day Old Ross Broilers. Asian-Australasian Journal of Animal Science.2017.

13. Wenqian Feng^#, Yancheng Wu^#, Guangxin Chen^#, Shoupeng Fu, Bai Li, Bingxu Huang, Dali Wang, Wei Wang and Juxiong Liu. Sodium Butyrate Attenuates Diarrhea in Weaned Piglets and Promotes Tight Junction Protein Expression in Colon in a GPR109A-Dependent Manner.  Cellular physiology and biochemistry, 2018; 47:1617-1629. (SCI, IF=5.104). 并列第一作者

14. Xin Ran^#, Yuhang Li^#, Guangxin Chen^#, Shoupeng Fu, Dewei He, Bingxu Huang, Libin Wei, Yuanqing Lin, Yingcheng Guo and Guiqiu Hu. Farrerol Ameliorates TNBS-Induced Colonic Inflammation by Inhibiting ERK1/2, JNK1/2, and NF-κB Signaling Pathway. International Journal of Molecular Sciences 2018, 19(7). (IF=5.6). 并列第一作者.