山西大学生物医学研究院

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吴长新

吴长新 博士（剑桥）

教授（二级）博士生导师

电子邮箱：cxw20@sxu.edu.cn

联系电话：

0086-351-7018958

行政任职

院长 2015.06 至今	山西大学生物医学研究院院长
学科负责人 2018.09 至今	山西大学生物医学研究院学科建设负责人
首席科学家 2022.01 至今	国家地方高校“地域性重要疾病病理机制与新干预技术研究”学科建设引智基地

个人简介

吴长新教授主要从事感染与免疫和人类疾病遗传学基础研究，聚焦地域性重大疾病病理机制与新干预技术研究。回国前后主持国家支撑计划、惠康基金会(Wellcome Trust)、国家基金项目和英国生物技术理事会（BBSRC）等项目，作为骨干参与承担国家973项目、国家重点科技计划和欧盟第七框架重大项目等项目子课题。主要科学与学术成就在《Science》、《Nature﹒Genetics》、《PNAS》、《Molecular Cell》、《Cell Death & Disease》、《Biosensors & Bioelectronics》、《Stem Cell Research & Therapy》、《Frontiers in Immunology》和《Clinical Immunology》等期刊发表。获得国内和国际学术组织授予奖项包括国家科技部科学进步二等，农业部科技进步二等奖，国级多个一级学会论文奖、Wellcome Trust国际青年科学家发展奖荣誉和剑桥大学海外奖学金委员会终生荣誉会员。

获得英国剑桥大学博士学位后，在剑桥工作近二十年，应山西大学邀请，在国家中西部高校综合实力提升工程经费资助下，组建山西大学生物医学研究院，并于山西大学115周年华诞之日—2017年5月8日成立。在山西省海外高层次人才和山西省高层次引进人才创新团队等人才支持计划资助下，辞去剑桥大学工作职位，2018年全职加盟山西大学，担任生物医学研究院创院院长（现任）和首席科学家、医学分子细胞生物学山西省重点实验室首任实验室主任和国家地方高校“地域性重要疾病病理机制与新干预技术”引智基地首席科学家。目前担任山西省战略科学家、山西省特聘专家以及地方和国家一些生命科学和医学专业学术团体理事、常务理事等。

研究领域

吴长新教授团队研究的兴趣主要在感染与免疫、罕见病和干细胞三个领域：

【感染与免疫】聚焦结核病病理机制与新干预技术，深入探索结核病（Tuberculosis，TB）易感性分子细胞生物学机制、结核分枝杆菌（mycobacterium tuberculosis,mtb）蛋白与宿主蛋白相互作用对TB病理发生与发展，宿主对Mtb免疫应答与清除的分子细胞生物学机制，以自然宿主作为模式生物，研发宿主导向性干预人类TB，特别是难治和耐药TB的新技术研发。同时开展其他感染性疾病的快速、特异、敏感诊断与病原检测新技术的研发。团队本方向课题组负责人包括尚桂军教授、邢力教授、董丽教授、孟庆来教授、李建国副教授、冯娇副教授、陈广信副教授、崔晓钢博士授、杨彩婷博士、王晶博士、刘月博士、杨志强博士、安一娜博士和曹珮珮博士等职业科学家。

【罕见病】聚焦地域性罕见病病理机制与新干预技术，深入开展神经性和代谢相关罕见病病理机制研究，应用基因编辑技术构建小鼠和斑马鱼模式动物，研究基因缺陷导致相关罕见病的分子细胞生物学机制，并试图通过最新基因编辑技术和核酸小分子研发罕见病的基因治疗的新干预技术。团队本方向课题组负责人包括赵仲华教授、熊秋宏副教授、李平副教授和刘婷博士等职业科学家。

【干细胞】聚集干细胞分化分子细胞生物学机制和干细胞技术在感染性疾病和罕见病方面的新干预技术，特别是胚胎干细胞早期分化机制。研发基于多能干细胞分化为功能干细胞的新型治疗技术，用于难治性耐药TB、神经退行性疾病及罕见代谢性疾病的临床干预。同时团队也对肿瘤干细胞干性形成机制及生物活性小分子对肿瘤干细胞干性影响与作用机制开展一些先导性基础性研究。团队课题组负责人包括姚明泽教授、董丽教授、张立超副教授和剌晓琴博士等职业科学家。

团队依托山西大学生命科学院生物学一级硕士博士学位点在二级遗传学（医学）培养学术型博士和硕士研究生，招生的方向与专业包括遗传学、生物化学与分子生物学和微生物学。

团队依托生命科学院生物工程和食品工程一级专业性型硕士学位点招生。

科研项目

吴长新教授回国前，依托国内大学主持国家自然科学基金5项，科技部支撑计划1项、英国BBRSC项目1项和英国Wellcome Trust项目2项；参与欧盟第七框架重大项目、国家863项目和973项目各1项。

2018年正式加盟山西大学以来和团队成员主持、合作主持和参加科技部、山西省科技厅和卫健委项目计32项。

主持项目

1. 国家基金面上项目：结节硬化症糖原储积异常分子细胞生物学病理机制研究。国家自然科学基金， 58万

2. 山西省指导研发项目：特异快速敏感鉴别诊断新型冠状病毒感染的肺炎试剂盒研制。山西省科技厅， 70万

3. 山西省高层次海外引进人才创新团队项目：“基因多态性调控结核病易感性机制研究”。山西省705万

4. 山西省高层次外籍引进人才项目：“结核病病原蛋白与宿主蛋白相互作用及机制研究”。山西省 150万

5. 山西省高层次外籍引进人才项目： “基因多态性调控结核病易感性机制研究”。山西省 80万

6. 山西省高层次外籍引进人才项目：“间充质干细胞治疗炎症性疾病”。山西省 80万

7. 国家科技计划：“畜禽重要胞内菌基因调控及其与宿主互作的分子机制研究”（任务），国家科技部 24万

8. 国家地方高校引智基地建设项目：“地域性重要疾病病理机制与新干预技术研究学科建设创新研究”，科技部与教育部 500万

9. 重点实验室建设项目：医学分子细胞生物学山西省重点实验室建设山西省科技厅 150万

10. 新布尼亚病毒抗原表达和抗体筛选研究合作项目 50 万

11. 科技创新项目：山西省干细胞产业技术创新联盟建设项目科技厅 20万

合作博士后

胡江宏博士

【本团队常年招聘博士后，保障科研条件和科研经费，随时受理入站申请。应聘人员可直接联系咨询或在山西大学人力资源处博士后管理办公室咨询或递交申请材料。申请材料可在我校人力资源处网站http://rsc.sxu.edu.cn/下载】。

在读研究生

博士研究生【与尚桂军教授和高山教授合作指导】

硕士研究生【与杨志强博士、安一娜博士和曹珮珮博士合作指导】

科研代表作：

1．Liu, S.; Yang, B.; Hou, Y.; Cui, K.; Yang, X.; Li, X.; Chen, L.; Liu, S.; Zhang, Z.; Jia, Y.; Xie, Y.; Xue, Y.; Li, X.; Yan, B.; Wu, C.; Deng, W.; Qi, J.; Lu, D.; Gao, G. F.; Wang, P.; Shang, G., The mechanism of STING autoinhibition and activation. Mol Cell 2023, 83 (9), 1502-1518.e10.

2．Yang, B.; Jia, Y.; Meng, Y.; Xue, Y.; Liu, K.; Li, Y.; Liu, S.; Li, X.; Cui, K.; Shang, L.; Cheng, T.; Zhang, Z.; Hou, Y.; Yang, X.; Yan, H.; Duan, L.; Tong, Z.; Wu, C.; Liu, Z.; Gao, S.; Zhuo, S.; Huang, W.; Gao, G. F.; Qi, J.; Shang, G., SNX27 suppresses SARS-CoV-2 infection by inhibiting viral lysosome/late endosome entry. Proc Natl Acad Sci U S A 2022, 119 (4).

3．Yaigoub, H.; Fath, N.; Tirichen, H.; Wu, C.; Li, R.; Li, Y., Bidirectional crosstalk between dysbiotic gut microbiota and systemic lupus erythematosus: What is new in therapeutic approaches? Clin Immunol 2022, 244, 109109.

4．Wen, D.; Cui, J.; Li, P.; Xiong, Q.; Chen, G.; Wu, C., Syndecan-4 assists Mycobacterium tuberculosis entry into lung epithelial cells by regulating the Cdc42, N-WASP, and Arp2/3 signaling pathways. Microbes Infect 2022, 24 (4), 104931.

5．Yang, C.; Ma, X.; Wu, J.; Han, J.; Zheng, Z.; Duan, H.; Liu, Q.; Wu, C.; Dong, Y.; Dong, L., Low serum calcium and phosphorus and their clinical performance in detecting COVID-19 patients. J Med Virol 2021, 93 (3), 1639-1651.

6．Li, J.; Li, Z.; Cui, X.; Wu, C., Bayesian phylodynamic inference on the temporal evolution and global transmission of SARS-CoV-2. J Infect 2020, 81 (2), 318-356.

7．Cuchet-Lourenço, D^#.; Eletto, D^#.; Wu, C^#.; Plagnol, V.; Papapietro, O.; Curtis, J.; Ceron-Gutierrez, L.; Bacon, C. M.; Hackett, S.; Alsaleem, B.; Maes, M.; Gaspar, M.; Alisaac, A.; Goss, E.; AlIdrissi, E.; Siegmund, D.; Wajant, H.; Kumararatne, D.; AlZahrani, M. S.; Arkwright, P. D.; Abinun, M.; Doffinger, R.; Nejentsev, S., Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation. Science 2018, 361 (6404), 810-813.

8．Curtis, J.; Luo, Y.; Zenner, H. L.; Cuchet-Lourenço, D.; Wu, C.; Lo, K.; Maes, M.; Alisaac, A.; Stebbings, E.; Liu, J. Z.; Kopanitsa, L.; Ignatyeva, O.; Balabanova, Y.; Nikolayevskyy, V.; Baessmann, I.; Thye, T.; Meyer, C. G.; Nürnberg, P.; Horstmann, R. D.; Drobniewski, F.; Plagnol, V.; Barrett, J. C.; Nejentsev, S., Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration. Nat Genet 2015, 47 (5), 523-527.

9．Yang, J.; Li, X.; Al-Lamki, R. S.; Wu, C.; Weiss, A.; Berk, J.; Schermuly, R. T.; Morrell, N. W., Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension. Arterioscler Thromb Vasc Biol 2013, 33 (1), 34-42.

10．Angulo, I.; Vadas, O.; Garçon, F.; Banham-Hall, E.; Plagnol, V.; Leahy, T. R.; Baxendale, H.; Coulter, T.; Curtis, J.; Wu, C.; Blake-Palmer, K.; Perisic, O.; Smyth, D.; Maes, M.; Fiddler, C.; Juss, J.; Cilliers, D.; Markelj, G.; Chandra, A.; Farmer, G.; Kielkowska, A.; Clark, J.; Kracker, S.; Debré, M.; Picard, C.; Pellier, I.; Jabado, N.; Morris, J. A.; Barcenas-Morales, G.; Fischer, A.; Stephens, L.; Hawkins, P.; Barrett, J. C.; Abinun, M.; Clatworthy, M.; Durandy, A.; Doffinger, R.; Chilvers, E. R.; Cant, A. J.; Kumararatne, D.; Okkenhaug, K.; Williams, R. L.; Condliffe, A.; Nejentsev, S., Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Science 2013, 342 (6160), 866-71.

11．Goodall, J. C^#.; Wu, C^#.; Zhang, Y.; McNeill, L.; Ellis, L.; Saudek, V.; Gaston, J. S., Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Proc Natl Acad Sci U S A 2010, 107 (41), 17698-703.

科研文章：

1．Zhang, M.; Wu, C.; Lu, D.; Wang, X.; Shang, G. cGAS-STING: mechanisms and therapeutic opportunities. Science China. Life sciences 2025.

2．Feng, J.; Wu, C.; Zhou, D.; Hu, L.; Mu, K.; Yin, Z. Insights into incompatible plasmids in multidrug-resistant Raoultella superbugs. BMC microbiology2025, 25(1), 55.

3．Zhao, N.; Xiong, Q.; Li, P.; Chen, G.; Xiao, H.; Wu, C. TSC complex decrease the expression of mTOR by regulated miR-199b-3p. Scientific reports2025, 15(1), 1892.

4．La, X.; Zhang, Z.; Liang, J.; Li, H.; Pang, Y.; He, X.; Kang, Y.; Wu, C.; Li, Z. Isolation and purification of flavonoids from quinoa whole grain and its inhibitory effect on lipid accumulation in nonalcoholic fatty liver disease by inhibiting the expression of CD36 and FASN. Journal of the science of food and agriculture2025, 105(2), 1330–1342.

5．Cui, X.; Zhang, F.; Meng, H.; Yuan, T.; Li, M.; Yuan, D.; Fan, X.; Jia, X.; Wang, Q.; Xing, L.;Wu, C. Transport of miR-766-3p to A549 cells by plasma-derived exosomes and its effect on intracellular survival of Mycobacterium tuberculosis by regulating NRAMP1 expression in A549 cells. Microbiological research 2025, 290, 127943.

6．Ma, D.; Yao, H.; Liu, Y.; Gong, W.; Zhao, Y.; Wang, R.; Wu, C.; Wang, W.; Wang, H. The reduced interaction between SufS and SufU in Mycoplasma penetrans results in diminished sulfotransferase activity. International journal of biological macromolecules2025, 284(Pt 2), 138181.

7．Yang, Q.; Zhou, Y.; Farooq, W.; Liu, Q.; Duan, J.; Xing, L.; Wu, C.; Dong, L. The immunomodulatory effects of Mesenchymal stem cells on THP-1-derived macrophages against Mycobacterium tuberculosis H37Ra infection. Tuberculosis (Edinburgh, Scotland) 2025, 150, 102593.

8．Li, P.; Wu, Y.; Deng, Z.; Samad, A.; Xi, Y.; Song, J.; Zhang, Y.; Li, J.; Zhou, Y. A.; Xiong, Q.; Wu, C. Two novel SH3TC2 mutations predispose to Charcot-Marie-Tooth disease type 4C by mistargeting away from TFRC. Cellular signalling 2025, 130, 111669.

9．Li, P.; Xi, Y.; Zhang, Y.; Samad, A.; Lan, W.; Wu, Y.; Zhao, J.; Chen, G.; Wu, C.; Xiong, Q. GLA Mutations Suppress Autophagy and Stimulate Lysosome Generation in Fabry Disease. Cells2024, 13(5), 437.

10．Yang, C.; Wang, H.; Shao, M.; Chu, F.; He, Y.; Chen, X.; Fan, J.; Chen, J.; Cai, Q.; Wu, C. Brain-Type Glycogen Phosphorylase (PYGB) in the Pathologies of Diseases: A Systematic Review. Cells 2024, 13(3), 289.

11．Xiong, Q.; Sun, H.; Wang, Y.; Xu, Q.; Zhang, Y.; Xu, M.; Zhao, Z.; Li, P.; Wu, C. Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn. Lipids in health and disease 2024, 23(1), 91.

12．Chen, G.; Shen, L.; Hu, H.; Feng, Y.; Wen, D.; Liu, Y.; Zhai, H.; Sun, W.; Wang, M.; Lei, X.; Li, P.; Xiong, Q.; Wu, C. Sulforaphane Inhibits Oxidative Stress and May Exert Anti-Pyroptotic Effects by Modulating NRF2/NLRP3 Signaling Pathway in Mycobacterium tuberculosis-Infected Macrophages. Microorganisms 2024, 12(6), 1191.

13．Wang, P. H.; Wang, Y.; Guo, Y. Y.; Ma, Z. H.; Wu, C.; Xing, L. Ibuprofen modulates macrophage polarization by downregulating poly (ADP-ribose) polymerase 1. International immunopharmacology 2024, 143(Pt 3), 113502.

14．Han, J.; Kang, X.; Su, Y.; Wang, J.; Cui, X.; Bian, Y.; Wu, C. Plasma exosomes from patients with coronary artery disease promote atherosclerosis via impairing vascular endothelial junctions. Scientific reports 2024, 14(1), 29813.

15．Li, J.; Cheng, R.; Bian, Z.; Niu, J.; Xia, J.; Mao, G.; Liu, H.; Wu, C.; Hao, C. Development of multiplex allele-specific RT-qPCR assays for differentiation of SARS-CoV-2 Omicron subvariants. Applied microbiology and biotechnology 2024, 108(1), 35.

16．Cui, X.; Meng, H.; Li, M.; Chen, X.; Yuan, D.; Wu, C. Exosomal Small RNA Sequencing Profiles in Plasma from Subjects with Latent Mycobacterium tuberculosis Infection. Microorganisms 2024, 12(7), 1417.

17．La, X.; Zhang, Z.; Dong, C.; Li, H.; He, X.; Kang, Y.; Wu, C.; Li, Z.. Isorhamnetin in Quinoa Whole-Grain Flavonoids Intervenes in Non-Alcoholic Fatty Liver Disease by Modulating Bile Acid Metabolism through Regulation of FXR Expression. Foods (Basel, Switzerland) 2024, 13(19), 3076.

18．Meng, C.; Chen, G.; Liu, Y.; Wen, D.; Cui, J.; Dong, L.; Yang, Z.; Meng, H.; Gao, Y.; Feng, J.; Cui, X.; Wu, C. miR-4687-5p Affects Intracellular Survival of Mycobacterium tuberculosis through Its Regulation of NRAMP1 Expression in A549 Cells. Microorganisms 2024, 12(1), 227.

19．Nie, R.; Zhang, W.; Tian, H.; Li, J.; Ling, Y.; Zhang, B.; Zhang, H.; Wu, C. Proteo-transcriptomic profiles reveal key regulatory pathways and functions of LDHA in the ovulation of domestic chickens (Gallus gallus). Journal of animal science and biotechnology 2024, 15(1), 68.

20．Nie, R.; Zhang, W.; Tian, H.; Li, J.; Ling, Y.; Zhang, B.; Zhang, H.; Wu, C. Regulation of Follicular Development in Chickens: WIF1 Modulates Granulosa Cell Proliferation and Progesterone Synthesis via Wnt/β-Catenin Signaling Pathway. International journal of molecular sciences 2024, 25(3), 1788.

21．La, X.; He, X.; Liang, J.; Zhang, Z.; Li, H.; Liu, Y.; Liu, T.; Li, Z.; Wu, C. Gastroprotective Effect of Isoferulic Acid Derived from Foxtail Millet Bran against Ethanol-Induced Gastric Mucosal Injury by Enhancing GALNT2 Enzyme Activity. Nutrients2024, 16(13), 2148. Isolation and purification of flavonoids from quinoa whole grain and its inhibitory effect on lipid accumulation in nonalcoholic fatty liver disease by inhibiting the expression of CD36 and FASN. Journal of the science of food and agriculture 2025, 105(2), 1330–1342.

22．Cui, X.; Zhang, F.; Meng, H.; Yuan, T.; Li, M.; Yuan, D.; Fan, X.; Jia, X.; Wang, Q.; Xing, L.; Wu, C. Transport of miR-766-3p to A549 cells by plasma-derived exosomes and its effect on intracellular survival of Mycobacterium tuberculosis by regulating NRAMP1 expression in A549 cells. Microbiological research 2025, 290, 127943.

23．Ma, D.; Yao, H.; Liu, Y.; Gong, W.; Zhao, Y.; Wang, R.; Wu, C.; Wang, W.; Wang, H. The reduced interaction between SufS and SufU in Mycoplasma penetrans results in diminished sulfotransferase activity. International journal of biological macromolecules2025, 284(Pt 2), 138181.

24．Tufail, M.; Wu, C.; Hussain, M. S. Dietary, addictive and habitual factors, and risk of colorectal cancer. Nutrition (Burbank, Los Angeles County, Calif.) 2024, 120, 112334.

25．Wen, D.; Meng, C.; Feng, Y.; Shen, L.; Liu, Y.; Sun, W.; Chen, G.; Wu, C. Syringaldehyde Exhibits Antibacterial and Antioxidant Activities against Mycobacterium marinum Infection. Microorganisms 2024, 12(2), 348.

26．Zhang, J.; Xu, W.; Xu, D.; Wu, C.; Xing, L. Diagnosis of a cystic lymphocyte-rich thymoma in a young cat. Veterinary research forum : an international quarterly journal 2024, 15(8), 439–443.

27．Chang, Y.; Wu, S.; Li, J.; Bao, H.; Wu, C. Identification of Candidate Genes for Red-Eyed (Albinism) Domestic Guppies Using Genomic and Transcriptomic Analyses. International journal of molecular sciences 2024, 25(4), 2175.

28．Chen, L.; Jin, J.; Shao, K.; Xu, Z.; Lv, L.; Wu, C.; Wang, Y. Mixture toxic mechanism of phoxim and prochloraz in the hook snout carp Opsariichthysbidens. Chemosphere 2024, 364, 143217.

29．Yang, Q.; Zhou, Y.; Farooq, W.; Liu, Q.; Duan, J.; Xing, L.; Wu, C.; Dong, L. The immunomodulatory effects of Mesenchymal stem cells on THP-1-derived macrophages against Mycobacterium tuberculosis H37Ra infection. Tuberculosis (Edinburgh, Scotland)2025, 150, 102593.

30．Meng, Q.; Wang, Y.; Long, Y.; Wang, Q.; Gao, Y.; Tian, J.; Wu, C.; Xie, B. The New Delhi metallo-β-lactamase-1 biosensor rapidly and accurately detected antibiotic plasma concentrations in cefuroxime-treated patients. International journal of antimicrobial agents2024, 64(2), 107229.

31．Bahoussi, A. N.; Shah, P. T.; Liu, Y.; Guo, Y. Y.; Bu, H.; Wu, C.; & Xing, L. (2024). Evolutionary History and Genetic Variation of Zika Virus: Connection Between Thailand Zika Viruses and Global Outbreaks Strains. Vector borne and zoonotic diseases (Larchmont, N.Y.)2024, 24(2), 122–128.

32．Hussain, B.; Wu, C. Evolutionary and Phylogenetic Dynamics of SARS-CoV-2 Variants: A Genetic Comparative Study of Taiyuan and Wuhan Cities of China. Viruses2024, 16(6), 907.

33．Zhang, L. C.; Liu, Y. N.; La, X. Q.; Li, S. T.; Wen, L. N.; Liu, T.; Li, H. Q.; Li, A. P.; Wu, H.; Wu, C. X.; Li, Z. Y.; The bound polyphenols of foxtail millet (Setaria italica) inner shell inhibit breast cancer by promoting lipid accumulation-induced autophagic death. Food Chem Toxicol 2023, 177, 113855

34．Xiong, Q.; Sun, H.; Xing, W.; Li, X.; Chen, G.; Zhao, Z.; Wu, C.; Li, P.; WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism. Free Radic Biol Med 2023, 201, 89-97.

35．Wang, P. H.; Nawal Bahoussi, A.; Tariq Shah, P.; Guo, Y. Y.; Wu, C.; Xing, L.; Genetic comparison of transmissible gastroenteritis coronaviruses. Front Vet Sci 2023, 10, 1146648.

36．Tufail, M.; Wu, C.; Wnt3a is a promising target in colorectal cancer. Med Oncol 2023, 40 (3), 86.

37．Tufail, M.; Wu, C.; SRPKs: a promising therapeutic target in cancer. Clin Exp Med 2023.

38．Tufail, M.; Wu, C.; Exploring the Burden of Cancer in Pakistan: An Analysis of 2019 Data. J Epidemiol Glob Health 2023.

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