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张立超

  

38af811a513b46f08e9f95c49cc65f03.jpg 张立超 博士
副教授 硕士生导师
Email:zlc@sxu.edu.cn


工作经历:

       2017年7月-2019年11月 山西大学生物医学研究院 讲师

       2019年12月至今 山西大学生物医学研究院 副教授

       2019年荣获“三晋英才”青年优秀人才称号

       中国细胞生物学学会会员

       中国药理学会会员


主要研究方向:

肿瘤干细胞及其代谢异常在肿瘤发生发展中的作用以及机制,同时聚焦相关靶向药物和药食同源天然药物的研究与开发。相关研究成果发表于Cell Death & Disease,Journal of Ethnopharmacology, International Journal of Biological Macromolecules,  J Agric Food Chem, Cellular Signalling, BMC biotechnologyThe international journal of biochemistry & cell biology等杂志。目前的研究主要集中在:

1. 肿瘤干细胞在肿瘤发生发展中的作用及机制

2. 糖脂代谢异常与肿瘤等重大疾病的关系

2. 药食同源天然产物中药物的筛选以及抗病机制研究


招生专业:

1.学术型硕士:遗传学、生物化学与分子生物学、细胞生物学

2.专业型硕士:食品加工与安全


代表性论文:

1、Lichao Zhang #, Xiaoqing Lu #, Yuanzhi Xu #, Xiaoqin La, Jinmiao Tian, Aiping Li, Hanqing Li, Changxin Wu, Yanfeng Xi, Guisheng Song, Zhaocai Zhou, Wenqi Bai*, Liwei An*, Zhuoyu Li*, Tumor-associated macrophages confer colorectal cancer 5-fluorouracil resistance by promoting MRP1 membrane translocation via an intercellular CXCL17/CXCL22-CCR4-ATF6-GRP78 axis, Cell Death & Disease. 2023 Sep 1;14(9):582. SCI(一区Top), IF:9.000

2、Lichao Zhang*, Ya-ning Liu, Xiao-qin La, Shuai-tao Li, Li-na Wen, Ting Liu, Han-qing Li, Ai-ping Li, Haitao Wu, Chang-xin Wu, Zhuo-yu Li*, The bound polyphenols of foxtail millet (Setaria italica) inner shell inhibit breast cancer by promoting lipid accumulation-induced autophagic death, Food and Chemical Toxicology, 177 (2023) 113855. SCI(二区, IF4.3

3、Yuxuan An#, Xiaoqin La#, Songtao Li, Jinmiao Tian, Xiaxia Fan, Kaili Cui, Lichao Zhang*, Zhuoyu Li*. Polyphenols from whole millet grain(Setaria italica) alleviate glucose and lipid homeostasis in diet-induced-obese mice by increasing endogenous GLP-1, Journal of the Science of Food and Agriculture. 2023 Aug. DOI:10.1002/jsfa.12901.SCI(二区Top, IF4.099(共同通讯作者)

4、Jinmiao Tian#, Lichao Zhang#*, Xiaoqin La, Xiaxia Fan, Aiping Li, Changxin Wu, Yuxuan An, Shuning Yan, Xiushan Dong, Haitao Wu, Zhuoyu Li*. Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism, Cellular Signalling. 2023 Aug:108:110719. SCI(二区), IF:4.800(共同第一作者和通讯作者)

5、Xiaxia Fan#,Lichao Zhang#*,Xiaoqin La#,Jinmiao Tian,Ghani Israr,Aiping Li,Changxin Wu,Yuxuan An,Songtao Li,Xiushan Dong,Zhuoyu Li*,Salvianolic acid A attenuates inflammation-mediated atherosclerosis by suppressing GRP78 secretion of endothelial cells,Journal of Ethnopharmacology. 2023 May 23:308:116219. SCI(二区 Top), IF:5.399(共同第一作者和通讯作者)

6、Aiping Li,Wenbo Cui,Yirui Zhao,Tingting Luo,Qingyu Zhang,Yuetao Liu,Ke Li,Xuemei Qin*,Lichao Zhang*Exploration of the main effective constituent and the mechanism in Astragali Radix in the treatment for doxorubicin-induced nephropathy by integrating metabolomics and molecular docking,Journal of Ethnopharmacology,305 (2023) 116074,SCI(二区 Top), IF:5.195

7、Aiping Li,Wenbo Cui,Yirui Zhao,Tingting Luo,Qingyu Zhang,Yuetao Liu,Ke Li,Xuemei Qin*,Lichao Zhang*Exploration of the main effective constituent and the mechanism in Astragali Radix in the treatment for doxorubicin-induced nephropathy by integrating metabolomics and molecular docking,Journal of Ethnopharmacology,305 (2023) 116074,SCI(二区 Top), IF:5.195

8、Kaili Cui#Lichao Zhang#,Xiaoqin La,Haili Wu,Ruipeng Yang,Hanqing Li,Zhuoyu Li*, Ferulic Acid and P-Coumaric Acid Synergistically Attenuate Non-Alcoholic Fatty Liver Disease through HDAC1/PPARG-Mediated Free Fatty Acid Uptake, International Journal Of Molecular Sciences2022, 23(23), 15297. SCI(二区 Top), IF:6.208(共同第一作者和通讯作者)

9、Lichao Zhang,Yaning Liu,Xiaoqin La,Shuning Yan,Yu Chen,Jingyi Liang,Zhuoyu Li*,The potential mechanism of Neu5Gc inducing colorectal cancer based on network pharmacology and experimental validation,Naunyn-Schmiedeberg's Archives of Pharmacology, (2022). https://doi.org/10.1007/s00210-022-02345-w,SCI(三区 ), IF:3.195

10、Lichao Zhang#, Xiaoqin La#, Jinmiao Tian, Hanqing Li, Aiping Li, Yizhi Liu, Changxin Wu, Zhuoyu Li*, The phytochemical vitexin and syringic acid derived from foxtail fillet bran inhibit breast cancer cells proliferation via GRP78/SREBP-1/SCD1 signaling axis, Journal of Functional Foods. 2021, 85, 104620. SCI(二区), IF:4.451

11、 Xiaoqing Lu#, Rui Yang#, Lichao Zhang#, Yanfeng Xi, Jiping Zhao, Fusheng Wang, Huanhu Zhang, Zhuoyu Li*, Macrophage Colony-stimulating Factor Mediates the Recruitment of Macrophages in Triple negative Breast Cancer. International Journal of Biological Sciences2019; 15(13): 2859-2871. SCI(二区), IF:4.067(共同第一作者)

12、Xiaoqin La#, Lichao Zhang#, Yufei Yang, Hanqing Li, Guisheng Song, Zhuoyu Li*. Tumor-secreted GRP78 facilitates the migration of macrophages into tumors by promoting cytoskeleton remodeling. Cellular Signalling. 2019; 60: 1-16. SCI(二区), IF:4.32(共同第一作者)

13、Xiaoqin La#, Lichao Zhang#, Zhuoyu Li*, Hanqing Li, Yufei Yang.(-)-Epigallocatechin Gallate (EGCG) Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU by Inhibiting GRP78/NF-κB/miR-155-5p/MDR1 Pathway. J Agric Food Chem. 2019; 67 (9), 2510-2518. SCI (一区), IF:3.14(共同第一作者)

14、Yufei Yang#, Lichao Zhang#, Xiaoqin La# , Zhuoyu Li*, Hanqing Li, Songjia Guo. Salvianolic acid A inhibits tumor-associated angiogenesis by blocking GRP78 secretion. Naunyn-Schmiedeberg's Archives of Pharmacology. 2019; 392 (4), 467-480. SCI(三区), IF:2.39(共同第一作者)

15、Lichao Zhang, Zongwei Li, Guobin Ding, Xiaoqin La, Peng Yang, Zhuoyu Li*. GRP78 plays an integral role in tumor cell inflammation-related migration induced by M2 macrophages. Cellular Signalling. 2017;37:136-48. SCI(二区),IF:4.32

16、Lichao Zhang, Zongwei Li, Tongli Shi, Xiaoqin La, Hanqing Li, Zhuoyu Li*. Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic for targeting cancer cells. BMC biotechnology. 2016; 16:1-13. SCI(二区),IF:2.45

17、Lichao Zhang, Zongwei Li, Yongsheng Fan, Hanqing Li, Zhuoyu Li*, Yaoping Li. Overexpressed GRP78 affects EMT and cell-matrix adhesion via autocrine TGF-beta/Smad2/3 signaling. The international journal of biochemistry & cell biology. 2015; 64:202-11. SCI(二区),IF:3.91

18、Zongwei Li#,Lichao Zhang#, Hanqin Li, Shuhua Shan, Zhuoyu Li*. Glucose regulated protein 78 promotes cell invasion via regulation of uPA production and secretion in colon cancer cells. BMB Reports. 2014; 47:445-50. SCI(三区),IF:2.78(共同第一作者)

19、Zongwei Li, Lichao Zhang, Yarui Zhao, Hanqing Li, Hong Xiao, Rong Fu, et al. Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion. The international journal of biochemistry & cell biology. 2013; 45:987-94. SCI(二区),IF:3.91

20、Zongwei Li, Ming Zhuang, Lichao Zhang, Xingnan Zheng, Peng Yang, Zhuoyu Li*. Acetylation modification regulates GRP78 secretion in colon cancer cells. Scientific reports. 2016; 6:30406. SCI(二区),IF:5.22

21、Zongwei Li, Yingying Wang, Haili Wu, Lichao Zhang, Peng Yang. GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the β-catenin signaling. Oncotarget. 2014. SCI(一区),IF:5.00

22、Zongwei Li, Yingying Wang, Ian P. Newton, Lichao Zhang, Penyu Ji, Zhuoyu Li*. GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKKbeta. Cellular signalling. 2015; 27:1237-45. SCI(二区),IF:4.19

 

发明专利:

一种靶向抗肿瘤活性蛋白及其制备与纯化;李卓玉,张立超,李宗伟,史通麟,杨鹏,李汉卿;发明专利;专利号:ZL 2015 1 0718882. X


科研项目:

1、山西省中央引导地方科技发展资金项目,YDZJSX2022A006,丹酚酸A通过调控核苷酸代谢促进肿瘤血管正常化提高化疗效率的机制研究,2022/11-2026/11,35万元,在研,主持

2、山西省国际间合作项目,201903D421055,GRP78通过调节脂肪酸氧化代谢促进肿瘤发展的机制研究,2019/12-2022/12,10万元,在研,主持

3、国家自然科学青年基金,81803791,丹酚酸A通过抑制GRP78分泌调控微环境逆转肿瘤耐药的分子机制,2019/01-2021/12,20万元,已结题,主持

4、山西省应用基础研究面上青年基金项目,201801D221249,肿瘤分泌型GRP78通过调节脂代谢促进巨噬细胞M2型极化的机制研究,2018/12-2020/12,3万元,已结题,主持

5、山西省高等学校科技创新项目,2019L0032,谷糠结合态多酚通过诱导饱和脂肪酸积累促进乳腺癌细胞自噬性死亡的机制研究,2019/6-2021/6,3万元,已结题,主持

6、山西省研究生教育改革课题项目,2019JG025,《发育遗传学》教学改革与实践探索,2019/6-2022/6,1万元,已结题,主持

7、国家自然科学青年基金,81803238,芹菜素与PKM2相互作用抑制有氧糖酵解发挥抗肿瘤效应的分子机制2019/01-2021/12,21万元,已结题,主要参与人

8、国家自然科学青年基金,81803321,外泌体细胞粘附相关膜蛋白与宫颈癌发病风险的队列研究 2019/01-2021/12,22万元,已结题,主要参与人

9、山西省应用基础研究面上基金项目,201801D121289,外泌体Survivin蛋白在HPV感染者宫颈病变进展中的作用研究,2019/01-2021/12,5万元,已结题,主要参与人




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