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郑耀武
郑耀武   博士
教授   博士生导师
Email:zhengyw442@nenu.edu.cn

教育经历:

学士学位:山西大学生物系植物生理专业

博士学位:美国南卡罗来纳大学生物系分子遗传学专业

 

工作经历:

1982年1月至1985年1月:山西大学生物系  助教

1985年1月至1990年9月:美国南卡罗来纳大学生物系研  究助教

1990年10月至1993年10月:美国加州大学旧金山分校      博士后

1993年11月至今:美国加州大学旧金山分校心血管研究所   研究员

2010年10月至2017年3月:东北师范大学教授、博导

  

 代表性学术论文

1. Expression Patterns and Potential Biological Roles of Dip2a. Zhang L, Mabwi HA, Palange NJ, Jia R, Ma J, Bah FB, Sah RK, Li D, Wang D, Bah FB, Togo J, Jin H, Ban L, Feng X, Zheng Y. PLoS One. 2015 Nov 25;10(11):e0143284. doi: 10.1371/journal.pone.0143284. eCollection 2015.

2. c-Fos is involved in inhibition of human bladder carcinoma T24 cells by brazilin. Zhang T, Fan X, Song L, Ren L, Ma E, Zhang S, Ren L, Zheng Y, Zhang J. IUBMB Life. 2015 Mar;67(3):175-81. doi: 10.1002/iub.1357. Epub 2015 Apr 11.

3. Large Genomic Fragment Deletions and Insertions in Mouse Using CRISPR/Cas9. Zhang L, Jia R, Palange NJ, Satheka AC, Togo J, An Y, Humphrey M, Ban L, Ji Y, Jin H, Feng X, Zheng Y. PLoS One. 2015 Mar 24;10(3):e0120396. doi: 10.1371/journal.pone.0120396. eCollection 2015.

4. Regulation of renal fibrosis by Smad3 Thr388 phosphorylation. Qu X, Li X, Zheng Y, Ren Y, Puelles VG, Caruana G, Nikolic-Paterson DJ, Li J. Am J Pathol. 2014 Apr;184(4):944-52. doi: 10.1016/j.ajpath.2013.12.003. Epub 2014 Jan 30.

5. Transcriptional profiling of mouse uterus at pre-implantation stage under VEGF repression. Ji Y, Lu X, Zhong Q, Liu P, An Y, Zhang Y, Zhang S, Jia R, Tesfamariam IG, Kahsay AG, Zhang L, Zhu W, Zheng Y. PLoS One. 2013;8(2):e57287. doi: 10.1371/journal.pone.0057287. Epub 2013 Feb 28.

6. Comment on: Elias et al. Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance. Diabetes 2012;61:1801-1813. Lu X, Zheng Y. Diabetes. 2013 Jan;62(1):e3. doi: 10.2337/db12-1130. No abstract available.

7. High-resolution crystal structure of human protease-activated receptor 1. Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK. Nature. 2012 Dec 20;492(7429):387-92. doi: 10.1038/nature11701. Epub 2012 Dec 9.

8. Resistance to obesity by repression of VEGF gene expression through induction of brown-like adipocyte differentiation. Lu X, Ji Y, Zhang L, Zhang Y, Zhang S, An Y, Liu P, Zheng Y. Endocrinology. 2012 Jul;153(7):3123-32.

9. Genetic repression of mouse VEGF expression regulates coagulation cascade. Liu X, Hao L, Zhang S, Ji Y, Zhang Y, Lu X, Shi B, Pei H, Wang Y, Chen D, Guan X, Zheng Y. IUBMB Life. 2010 Nov;62(11):819-24. doi: 10.1002/iub.389.

10. Podocyte-specific VEGF down-regulation and pathophysiological development. Zhang S, Ji Y, Liu X, Lu X, Su W, Zhang D, Hao F, Yi F, Guo L, Li X, Zheng Y. IUBMB Life. 2010 Sep;62(9):677-83. doi: 10.1002/iub.368.

11. Local protease signaling contributes to neural tube closure in the mouse embryo. Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srinivasan Y, Brown C, Xu SM, Regard JB, Lin CY, Craik CS, Kirchhofer D, Coughlin SR. Dev Cell. 2010 Jan 19;18(1):25-38. doi: 10.1016/j.devcel.2009.11.014.

12. Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. Regard JB, Kataoka H, Cano DA, Camerer E, Yin L, Zheng YW, Scanlan TS, Hebrok M, Coughlin SR. J Clin Invest. 2007 Dec;117(12):4034-43.

13. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Pappu R, Schwab SR, Cornelissen I, Pereira JP, Regard JB, Xu Y, Camerer E, Zheng YW, Huang Y, Cyster JG, Coughlin SR. Science. 2007 Apr 13;316(5822):295-8. Epub 2007 Mar 15.

14. De Candia E, Yao-Wu Z, Balduini CL et al. Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives. Thromb Haemost. 2007 Mar;5(3):551-9.

15. Roles of protease-activated receptors in a mouse model of endotoxemia. Camerer E, Cornelissen I, Kataoka H, Duong DN, Zheng YW, Coughlin SR. Blood. 2006 May 15;107(10):3912-21. Epub 2006 Jan 24.

16. Essential role for Galpha13 in endothelial cells during embryonic development. Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Yin L, Xu SM, Coughlin SR. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8281-6. Epub 2005 May 26.

17. Regulated shedding of PAR1 N-terminal exodomain from endothelial cells. Ludeman MJ, Zheng YW, Ishii K, Coughlin SR. J Biol Chem. 2004 Apr 30;279(18):18592-9. Epub 2004 Feb 24.

18. Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. Kataoka H, Hamilton JR, McKemy DD, Camerer E, Zheng YW, Cheng A, Griffin C, Coughlin SR. Blood. 2003 Nov 1;102(9):3224-31. Epub 2003 Jul 17.

19. Camerer E, Kataoka H, Zheng YW, Kahn M, Lease K, Coughlin SR. Genetic evidences that protease-activated receptors mediate factor Xa signaling in endothelial cells. J. Biol Chem. 2002 May 3;277(18):16081-7.

20. Role of thrombin signalling in platelets in haemostasis and thrombosis. Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR. Nature. 2001 Sep 6;413(6851):74-8.

21. A role for thrombin receptor signaling in endothelial cells during embryonic development. Griffin CT, Srinivasan Y, Zheng YW, Huang W, Coughlin SR. Science. 2001 Aug 31;293(5535):1666-70.

22. PAR3 is a cofactor for PAR4 activation by thrombin. Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR.Nature. 2000 Apr 6;404(6778):609-13.

23. A dual thrombin receptor system for platelet activation. Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV Jr, Tam C, Coughlin SR. Nature. 1998 Aug 13;394(6694):690-4.

24. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Cases S, Smith SJ, Zheng YW, Myers HM, Lear SR, Sande E, Novak S, Collins C, Welch CB, Lusis AJ, Erickson SK, Farese RV Jr. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13018-23.

25. ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization. Cases S, Novak S, Zheng YW, Myers HM, Lear SR, Sande E, Welch CB, Lusis AJ, Spencer TA, Krause BR, Erickson SK, Farese RV Jr. J Biol Chem. 1998 Oct 9;273(41):26755-64.

26. Protease-activated receptor 3 is a second thrombin receptor in humans. Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR. Nature. 1997 Apr 3;386(6624):502-6.

27. RVTI dentification and cloning of two new mammalian ACAT gene family members. Cases, S,Zheng, YW,Novak, S,Meiner, V,Myers, H,Erickson, SK,Farese, CIRCULATION,OCT 21,1997。Vol 96(8)SU Suppl. S,BP 1264,EP 1264

28. Genetic mapping of a possible new alcohol dehydrogenase sequence to mouse chromosome 3 at the Adh-1/Adh-3 complex. Zheng YW, Felder MR. Biochem Genet. 1997 Apr;35(3-4):105-17.

29. Ten kilobases of 5'-flanking region confers proper regulation of the mouse alcohol dehydrogenase-1 (Adh-1) gene in kidney and adrenal of transgenic mice. Xie D, Narasimhan P, Zheng YW, Dewey MJ, Felder MR. Gene. 1996 Nov 28;181(1-2):173-8.

30. Determinants of thrombin receptor cleavage. Receptor domains involved, specificity, and role of the P3 aspartate. Ishii K, Gerszten R, Zheng YW, Welsh JB, Turck CW, Coughlin SR. J Biol Chem. 1995 Jul 7;270(27):16435-40.

31. Ti Novel Small Transcripts Of The Hepatitis-B Virus X-Gene Journal Of Cellular Biochemistry. YEN, TSB,ZHENG, YW FEB 13,1994 SU Suppl. 18C,BP 218,EP 218

32. Novel short transcripts of hepatitis B virus X gene derived from intragenic promoter. Zheng YW, Riegler J, Wu J, Yen TS. J Biol Chem. 1994 Sep 9;269(36):22593-8.

33. Negative regulation of hepatitis B virus gene expression and replication by oxidative stress. Zheng YW, Yen TS. J Biol Chem. 1994 Mar 25;269(12):8857-62.  

34. Molecular basis of the alcohol dehydrogenase-negative deer mouse. Evidence for deletion of the gene for class I enzyme and identification of a possible new enzyme class. Zheng YW, Bey M, Liu H, Felder MR. J Biol Chem. 1993 Nov 25;268(33):24933-9. PMID:

35. Molecular analysis of mouse alcohol dehydrogenase: nucleotide sequence of the Adh-1 gene and genetic mapping of a related nucleotide sequence to chromosome 3. Ceci JD, Zheng YW, Felder MR. Gene. 1987;59(2-3):171-82.

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