崔晓钢   博士
	副教授   硕士生导师
	Email：xgcui@sxu.edu.cn

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教育经历：

2006.09-2010.07 华中农业大学 学士

2010.09-2015.07 中国农业大学 硕博连读 博士

工作经历：

2016.06-2017.07 美国佐治亚大学（University of Georgia）博士后研究

2018.01-至今 山西大学生物医学研究院

主要研究方向：

结核病是一种由结核分枝杆菌引发的严重传染性疾病，对全球公共卫生构成重大威胁。近年来，外泌体和铁死亡在医学研究领域备受瞩目，为结核病的研究开辟了新的方向。基于此主要研究方向如下：

1）探究结核感染状态下外泌体的释放机制、内容物组成及其对免疫细胞功能的调控作用

2）研究结核分枝杆菌感染如何诱导宿主细胞发生铁死亡，以及铁死亡对结核杆菌生存、传播和炎症反应的影响

3）非编码RNA通过调控铁死亡关键基因在结核分枝杆菌感染引发肺组织坏死中的作用机制

招生专业：

1、学术型硕士：遗传学、生物化学与分子生物学、微生物学

2、专业型硕士：生物与医药（生物工程、食品工程）

     

主持项目：

1. 中央引导地方科技发展资金项目，YDZJSX2024D010，患者来源miR-766-3p在调控巨噬细胞铁死亡促进结核病病理发生的机制研究，2024/07-2027/06，80万元，在研，主持

2. 山西省教育厅教改项目，理工医交叉融合的生物医学卓越人才培养模式研究，2024/06-2026/06，2万元，在研，主持

3. 企业合作项目，稷山板枣功能性产品的开发，2021.12 -2024.12，在研，主持

4. 企业合作项目，灵芝三贴酸功能性产品的开发，2021.12-2024.12，在研，主持

5. 企业合作项目，乳品质鉴定试剂盒的开发，2021.11-2024.11，在研，主持

6. 企业合作项目，生物多样性GAP分析软件的开发，2019-09至2021-08，在研，主持

7.  山西省高等学校科技创新项目，奶牛乳脂性状关键基因TRIB3及miRNA 对泌乳调控机制研究，2019.07-2021.07，已结题，主持

8.  山西省自然科学基金青年基金，基于高通量测序技术筛选奶牛乳成分相关miRNA并进行功能验证，2018.12-2020.12，已结题，主持

代表性论文：

1. Cui X, Zhang F, Meng H, Yuan T, Li M, Yuan D, Fan X, Jia X, Wang Q*, Xing L*, Wu C*. Transport of miR-766-3p to A549 cells by plasma-derived exosomes and its effect on intracellular survival of Mycobacterium tuberculosis by regulating NRAMP1 expression in A549 cells. Microbiol Res. 2025 Jan; 290:127943. (1区Top)

2. Cui X, Meng H, Li M, Chen X, Yuan D, Wu C*. Exosomal Small RNA Sequencing Profiles in Plasma from Subjects with Latent Mycobacterium tuberculosis Infection. Microorganisms. 2024 Jul 12;12(7):1417. (2区)

3. Meng C, Chen G, Liu Y, Wen D, Cui J, Dong L, Yang Z, Meng H, Gao Y, Feng J, Cui X*, Wu C*. miR-4687-5p Affects Intracellular Survival of Mycobacterium tuberculosis through Its Regulation of NRAMP1 Expression in A549 Cells. Microorganisms. 2024 Jan 22;12(1):227. (通讯作者，2区)

4. Han J†, Cui X†（同等一作）, Yuan T, Yang Z, Liu Y, Ren Y, Wu C, Bian Y*. Plasma-derived exosomal let-7c-5p, miR-335-3p, and miR-652-3p as potential diagnostic biomarkers for stable coronary artery disease. Front Physiol. 2023; 14:1161612. (2区Top)

5. Cui X, Li C, Wei Z, Meng H, Zhang F, Liu Y, Wu C, Yang S*. DDIT3 Governs Milk Production Traits by Targeting IL-6 to Induce Apoptosis in Dairy Cattle. Agriculture. 2023; 13(1):117. (2区)

6. Cui X, Yuan T, Ning P, Han J, Liu Y, Feng J, Lian F, Hao M, Dong L, Hao J, Xing L*, Wu C*. Polymorphisms in the ASAP1 and SP110 Genes and Its Association with the Susceptibility to Pulmonary Tuberculosis in a Mongolian Population. J Immunol Res. 2022; 2022:2713869. (3区)

7. Cui X, Yuan T, Fang Z, Feng J, Wu C*. Bta-miR-125a Regulates Milk-Fat Synthesis by Targeting SAA1 mRNA in Bovine Mammary Epithelial Cells. Agriculture. 2022; 12(3):344. (2区)

8. Cui X*, Zhang S, Zhang Q, Guo X, Wu C, Yao M, Sun D*. Comprehensive microRNA expression profile of the mammary gland in lactating dairy cows with extremely different milk protein and fat percentages. Front Genet. 2020; 11:548268. （2区）

9. Cui X, Marshall B, Shi N, Chen SY, Rekaya R, Liu HX*. RNA-Seq analysis on chicken taste sensory organs: An ideal system to study organogenesis. Sci Rep. 2017;7(1):9131. （2区）

10. Cui X, Hou Y, Yang S, Xie Y, Zhang S, Zhang Y, Zhang Q, Lu X, Liu GE, Sun D*. Transcriptional profiling of mammary gland in Holstein cows with extremely different milk protein and fat percentage using RNA sequencing. BMC Genomics. 2014; 15:226. (2区Top)

11. Li F, Li L, Zhang Y, Bai S, Sun L, Guan J, Zhang W, Cui X*, Feng J*, Tong Y*. Isolation and characterization of the novel bacteriophage vB_SmaS_BUCT626 against Stenotrophomonas maltophilia. Virus Genes. 2022;58(5):458-466. (共同通讯，4区)

参与发表论文（按发表时间顺序）：

1. Han J, Kang X, Su Y, Wang J, Cui X, Bian Y*, Wu C*. Plasma exosomes from patients with coronary artery disease promote atherosclerosis via impairing vascular endothelial junctions. Sci Rep. 2024 Nov 30;14(1):29813.

2. Yao M, Pan Y, Ren T, Yang C, Lei Y, Xing X, Zhang L, Cui X, Zheng Y, Xing L, Wu C. Loss of Dip2b leads to abnormal neural differentiation from mESCs. Stem Cell Res Ther. 2023 Sep 13;14(1):248.

3. Shah PT, Bahoussi AN, Cui X, Shabir S, Wu C, Xing L*. Genetic diversity, distribution, and evolution of chicken anemia virus: A comparative genomic and phylogenetic analysis. Front Microbiol. 2023; 14:1145225.

4. Liu G, Wang Z, Cui X, Yang S*. Component analysis of Xylaria sp. L1 sporocarps after solid-state fermentation by okara and its safety evaluation in mice and rats. Nat Prod Res. 2023; 37(5):852-856.

5. Yao M, Su P, Li Z, Cui X, Yang Q, Xing X, Lei Y, Lian M, Ren T, Wang X, Zheng Y*, Wu C*. Knockout of Dip2c in murine ES cell line IBMSe001-B-1 by CRISPR/Cas9 genome editing technology. Stem Cell Res. 2021; 53:102236.

6. Han J, Ning P, Ge A, Ma X, Alexander Burton J, Yang C, Cui X, Wu C*, Hao J, Dong L. Association of polymorphisms of innate immunity-related genes and tuberculosis susceptibility in Mongolian population. Hum Immunol. 2021; 82(4):232-239.

7. Yu W, Wang Z, Marshall B, Yoshida Y, Patel R, Cui X, Ball R, Yin L, Kawabata F, Tabata S, Chen W, Kelsh RN, Lauderdale JD, Liu HX*. Taste buds are not derived from neural crest in mouse, chicken, and zebrafish. Dev Biol. 2021; 471:76-88.

8. Yao M, Yang Q, Lian M, Su P, Cui X, Ren T, Wang X, Wu C, Zheng Y*. Generation of Dip2a homozygous knockout murine ES cell line IBMSe001-A-1 via CRISPR/Cas9 technology. Stem Cell Res. 2020; 45:101778.

9. Li J, Li Z, Cui X, Wu C*. Bayesian phylodynamic inference on the temporal evolution and global transmission of SARS-CoV-2. J Infect. 2020;81(2):318-356.

10. Ma F, Zhi C, Wang M, Li T, Khan SA, Ma Z, Jing Z, Bo C, Zhou Q, Xia S, Huang S, Huang S, Zhang Z, Jia H, Cui X, Yao M, Ji T*. Dysregulated NF-κB signal promotes the hub gene PCLAF expression to facilitate nasopharyngeal carcinoma proliferation and metastasis. Biomed Pharmacother. 2020; 125:109905.

11. Kramer N, Chen G, Ishan M, Cui X, Liu HX*. Early taste buds are from Shh+ epithelial cells of tongue primordium in distinction from mature taste bud cells which arise from surrounding tissue compartments. Biochem Biophys Res Commun. 2019; 515(1):149-155.

12. Fan Y, Wang P, Fu W, Dong T, Qi C, Liu L, Guo G, Li C, Cui X, Zhang S, Zhang Q, Zhang Y, Sun D*. Genome-wide association study for pigmentation traits in Chinese Holstein population. Anim Genet. 2014;45(5):740-4.

13. Xie Y, Yang S, Cui X, Jiang L, Zhang S, Zhang Q, Zhang Y, Sun D*. Identification and expression pattern of two novel alternative splicing variants of EEF1D gene of dairy cattle. Gene. 2014; 534(2):189-96.

14. 宁鹏媛;董丽;郝金奇;崔晓钢;杨彩婷;王爱欣;郝明媛;余艳琴;吴长新*; 蒙汉民族ASAP1、NRAMP1、SP110基因表达水平与结核病易感性关联分析. 中国动物传染病学报.2020.

 

获奖与荣誉称号

2021年指导初民学院本科生获“互联网+”一等奖

2021年获最佳指导教师奖

2022年指导初民学院本科生获“互联网+”二等奖

2023年参加科协组织的专业技术人才高级研究班生物信息学处理数据专题讲授

2023年参加白求恩医院组织的专业技术人才培训班关于生物信息学处理大数据专题讲授