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陈广信
陈广信 博士
讲师 硕士生导师
Email:chengx@sxu.edu.cn

教育和工作经历:

        2012年毕业于河北北方学院,同年进入广东海洋大学攻读硕士学位,2015年进入吉林大学动物医学学院,于2018年6月获得博士学位。2018年7月加入山西大学生物医学研究院。

 

主要研究方向:

        博士阶段主要研究GPR109A在动物肠道屏障通透性以及肠道炎症中的作用,并探索了GPR109A与小鼠肠道菌群的关系。此外,在抗神经炎症机制及其中药单体激动剂筛选方面做了大量工作。

 

目前的研究主要方向:

        人类重大疾病遗传学易感机制研究。主要开展宿主对结核分枝杆菌易感染机制研究

 

代表性论文:

1. Guangxin Chen, Xin Ran, Bai Li, Yuhang Li, Dewei He, Bingxu Huang, Shoupeng Fu, Juxiong Liu, Wei Wang. Sodium Butyrate Inhibits Inflammation andMaintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model. EBioMedicine, 2018, 30. (SCI, IF=6.183, 1).

2. Guangxin Chen, Bingxu Huang, Shoupeng Fu, Bai Li, Xin Ran, Dewei He, Liqiang Jiang, Yuhang Li, Liwei Xie, Juxiong Liu and Wei Wang. G Protein-Coupled Receptor 1 109A and Host Microbiota Modulate Intestinal Epithelial Integrity during Sepsis. Frontiers in Immunology (SCI, IF=5.511, 2).

3. Guangxin Chen, Shoupeng Fu, Wenqian Feng, Bingxu Huang, Shiyao Xu, Wei Wang and Juxiong Liu. AMP010014A09 in Sus Scrofa Encodes an Analog of G Protein-Coupled Receptor 109A, Which Mediates the Anti-Inflammatory Effects of Beta-Hydroxybutyric Acid. Cellular physiology and biochemistry, 2017, 42, 1420-1430. (SCI, IF=5.1042).

4. Guangxin Chen, Juxiong Liu, Liqiang Jiang, Xin Ran, Dewei He, Yuhang Li, Bingxu Huang, Wei Wang, Shoupeng Fu. Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson's Disease in Rats. International journal of molecular sciences 2017, 19, (1). (SCI, IF=3.226, 3).

5. Guangxin Chen, Juxiong Liu, Bingxu Huang, Xin Ran, Liqiang Jiang, Yuhang Li, Wei Wang, Shoupeng Fu. Peiminine protects dopaminergic neurons frominflammation-induced celldeath by inhibitingthe ERK1/2 and NF-κB signalling pathways. International Journal of Molecular Sciences 2018, 19(3). (SCI, IF=3.226, 3).

6. Guangxin Chen, Zhenhua Gao, Wenhui Chu, Zan Cao, Chunyi Li, Haiping ZhaoZhao. Effects of Chromium Picolinateon Fat Deposition, Activity and Genetic Expression of Lipid Metabolism-Related Enzymes in 21 Day Old Ross Broilers. Asian-Australasian Journal of Animal Science.2017. (SCI, IF=0.860, 4).

7. Wenqian Feng#, Yancheng Wu#, Guangxin Chen#, Shoupeng Fu, Bai Li, BingxuHuang, Dali Wang, Wei Wang and Juxiong Liu. Sodium Butyrate Attenuates Diarrhea in Weaned Piglets and Promotes Tight Junction Protein Expression in Colon in a GPR109A-Dependent Manner.  Cellular physiology and biochemistry, 2018; 47:1617-1629. (SCI, IF=5.52). 并列第一作者

8. Xin Ran#, Yuhang Li#, Guangxin Chen#, Shoupeng Fu, Dewei He, Bingxu Huang, Libin Wei, Yuanqing Lin, Yingcheng Guo and Guiqiu Hu. Farrerol Ameliorates TNBS-Induced Colonic Inflammation by Inhibiting ERK1/2, JNK1/2, and NF-κB Signaling Pathway. International Journal of Molecular Sciences 2018, 19(7). (SCI, IF=3.226, 3). 并列第一作者

9. Bingxu Huang, Dewei He, Guangxin Chen, Xin Ran, Wenjin Guo, Xingchi Kan, Wei Wang, Dianfeng Liu, Shoupeng Fu and Juxiong Liu. α-Cyperone inhibits LPS-induced inflammation in BV-2 cells through activation of Akt/Nrf2/HO-1 and suppression of the NF-κB pathway. Food & Function, 2018, 9(5). 

10. Bingxu Huang, Juxiong Liu, Dongxu Ma, Guangxin Chen, Wei Wang, Shoupeng Fu. Myricetin prevents dopaminergic neurons from undergoing neuroinflammation-mediated degeneration in a lipopolysaccharide-induced Parkinson's disease model. Journal of Functional Foods, 2018, 45, 452-461.

11. Bingxu Huang, Juxiong Liu, Chen Ju, Dongxue Yang, Guangxin Chen, Shiyao Xu, Yalong Zeng, Xuan Yan, WeiWang, Dianfeng Liu and Shoupeng Fu. Licochalcone A Prevents the Loss of Dopaminergic Neurons by Inhibiting Microglial Activation in Lipopolysaccharide (LPS)-Induced Parkinson’s Disease Models. International Journal of Molecular Sciences 2017, 18(10). (SCI, IF=3.226, 3).

12. Xuan Yan, Dianfeng Liu, Xiangyang Zhang, Dong Liu, Shiyao Xu , Guangxin Chen, Bingxu Huang, Wenzhi Ren, Wei Wang, Shoupeng Fu and Juxiong Liu. Vanillin Protects Dopaminergic Neurons against Inflammation-Mediated Cell Death by Inhibiting ERK1/2, P38 and the NF-κB Signaling Pathway. International Journal of Molecular Sciences 2017, 18(2). (SCI, IF=3.226, 3).

13. Dewei He, Bingxu Huang, Shoupeng Fu, Yuhang Li, Xin Ran, Yandan Liu, Guangxin Chen, Juxiong Liu and Dianfeng Liu. Tubeimoside I Protects Dopaminergic Neurons Against Inflammation-Mediated Damage in Lipopolysaccharide (LPS)-Evoked Model of Parkinson's Disease in Rats. International Journal of Molecular Sciences, 2018, 19(8). (SCI, IF=3.226, 3).

14. Jianhua Sun, Juxiong Liu, Bingxu Huang, Xingchi Kan, Guangxin Chen, Wei Wang and Shoupeng Fu. Kisspeptin-10 Induces-Casein Synthesis via GPR54 and Its Downstream Signaling Pathways in Bovine Mammary Epithelial Cells. International Journal of Molecular Sciences 2017, 18(12). (SCI, IF=3.226, 3).

 

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