邢力 博士
	教授 博士生导师
	E-mail：LL638@email.sxu.edu.cn

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教育背景

        扬州大学获硕士学位。中国科学院上海生物化学和细胞生物学研究所获博士学位。

研究方向

 (1) 抗传染病疫苗的设计及其免疫保护机制的研究。

        疫苗(Vaccine)是一种生物制剂，可以诱导人体产生对特定感染性疾病的免疫保护。通常由弱化或杀死的微生物，或其毒素或其表面蛋白制成。该物质刺激人体的免疫系统，将其识别为威胁，并进一步识别和破坏其将来可能遇到的与该物质相关的任何微生物。疫苗可以预防或减轻自然病原体将来感染的影响。结核病(Tuberculosis，又称TB）为结核杆菌感染引起的疾病, 通常造成肺部感染，也会感染身体的其他部分。现阶段我们以斑马鱼和海鱼结核分枝杆菌为模型，研究结核杆菌的感染和免疫反应的分子机制，并设计研究针对结核病的有效疫苗。

(2) 炎症反应发生的分子机制及其在细菌感染中的作用。

       炎症反应(Inflammation)是人体组织对有害刺激物（例如病原体，受损细胞或刺激物）的复杂生物反应的一部分，是涉及免疫细胞,血管和分子介质的保护性反应，是先天性免疫的机制。炎症的功能是消除引起细胞损伤的最初原因，清除原始损伤和炎症过程中受损的坏死细胞和组织，并开始组织修复。因此炎症反应也是身体对抗病原微生物感染的重要关节。理解炎症反应的机制对研发抗感染药物至关重要。

代表论文（*通讯作者）：

论文

1、ASAP1 regulates the uptake of Mycobacterium tuberculosis H37Ra in THP1-derived macrophages by remodeling actin cytoskeleton. Cui J, Chen G, Zhao Z, Wang L, Wen D, Xing L*, Wu C*. Tuberculosis. 2021 

2、Genetic drift of MERS-CoV in Saudi Arabia during 2012-2019. Pan YQ, Guo F, Bahoussi AN, Shi RZ, Li YQ, Xing L*. Zoonoses and Public Health. 2021.  PMID: 33966359; DOI: 10.1111/zph.12843

3、The Spike glycoprotein genes of Porcine epidemic diarrhea viruses isolated in China. Wang PH, Li YQ, Pan YQ, Guo YY, Guo F, Shi RZ, Xing L*. Veterinary Research. 2021 

4、The characteristics of spike glycoprotein gene of swine acute diarrhea syndrome coronavirus strain CH/FJWT/2018 isolated in China. Wang PH, Pan YQ, Guo YY, Shi RZ, Li YQ, Guo F, Xing L*.  Frontiers in Veterinary Science. 2021

5、RNA helicase A regulates replication of RNA viruses. Shi RZ, Pan YQ, Xing L*. Viruses. 2021 

6、A single nucleotide distinguishes SARS-CoV-2 in Wuhan outbreak in December 2019 from that in Beijing Xinfadi in June 2020, China. Pan YQ, Bahoussi AN, Guo F, Xing L*. New Microbes and New Infections. 2020

7、Current view on the helicase activity of RNA helicase A and its role in gene expression. Pan YQ, Xing L*.  Current Protein & Peptide Science. 2020 Nov 2. doi: 10.2174/1389203721666201103084122.  PMID: 33143622

8、Puzzling increase and decrease in COVID-19 cases in Pakistan. Shah PT, Xing L*. New Microbes and New Infections. 2020 Oct 17; doi: 10.1016/j.nmni.2020.100791. PMID: 33101693

9、RNA helicase A as co-factor for DNA viruses during replication. Guo F, Xing L*. Virus Research. 2021 Jan 2; 291:198206. doi: 10.1016/j.virusres.2020.198206. PMID: 33132162

10、Role of the OB-fold of RNA helicase A in the synthesis of HIV-1 RNA. Xing L*, Niu M, Kleiman L*. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2014 Nov;1839(11):1069-78. doi: 10.1016/j.bbagrm.2014.08.008. PMID: 25149208

11、Repetitive RNA unwinding by RNA helicase A facilitates RNA annealing. Koh HR, Xing L, Kleiman L, Myong S. Nucleic Acids Research. 2014 Jul;42(13):8556-64. doi: 10.1093/nar/gku523. PMID: 24914047

12、In vitro and in vivo analysis of the interaction between RNA helicase A and HIV-1 RNA. Xing L, Niu M, Kleiman L. Journal of Virology. 2012 Dec;86(24):13272-80. doi: 10.1128/JVI.01993-12. Epub 2012 Sep 26. PMID: 23015696

13、cis-Acting effects on RNA processing and Drosha cleavage prevent Epstein-Barr virus latency III BHRF1 expression. Xing L*, Kieff E*. Journal of Virology. 2011 Sep;85(17):8929-39. doi: 10.1128/JVI.00336-11. PMID: 21697496

14、Coordinate roles of Gag and RNA helicase A in promoting the annealing of formula to HIV-1 RNA. Xing L, Liang C, Kleiman L. Journal of Virology. 2011 Feb;85(4):1847-60. doi: 10.1128/JVI.02010-10. PMID: 21106734

15、Epstein-Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication. Xing L, Kieff E. Journal of Virology. 2007 Sep;81(18):9967-75. doi: 10.1128/JVI.02244-06. PMID: 17626073

16、Epstein-Barr virus and virus human protein interaction maps. Calderwood MA, Venkatesan K, Xing L, Chase MR, Vazquez A, Holthaus AM, Ewence AE, Li N, Hirozane-Kishikawa T, Hill DE, Vidal M, Kieff E, Johannsen E. Proc Natl Acad Sci USA. 2007 May 1;104(18):7606-11. doi: 10.1073/pnas.0702332104. PMID: 17446270

17、Adenovirus-mediated expression of pig alpha (1, 3) galactosyltransferase reconstructs Gal alpha (1, 3) gal epitope on the surface of human tumor cells. Xing L, Xia GH, Fei J, Huang F, Guo LH. Cell Research. 2001 Jun;11(2):116-24. doi: 10.1038/sj.cr.7290076. PMID: 11453543

18、FUT2 gene involved in expression of H blood group antigen on surface of human tumor cell lines BEL-7404, SGC-7901, and SPC-A-1. Xing L, Guo LH. Acta Pharmacologica Sinica. 2000 Nov;21(11):997-1001. PMID: 11501068

19、Adenovirus-mediated expression of antisense RNA transcripts complementary to pig alpha (1,3) galactosyltransferase mRNA inhibits expression of Gal alpha (1,3) Gal epitope. Xing L, Xia GH, Bai XF, Fei J, Guo LH. Acta Pharmacologica Sinica. 2000 Nov;21(11):1005-10. PMID: 11501054

20、Adenovirus-mediated expression of human secretor type alpha (1,2) fucosyltransferase reduces level of Gal alpha (1,3) Gal epitope. Xing L, Xia GH, Fei J, Bai XF, Guo LH. Acta Pharmacologica Sinica. 2000 Sep;21(9):807-13. PMID: 11501162