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杨鹏 |
博士,硕导 | |
肿瘤分子实验室 | |
peng114011@sxu.edu.cn |
个人简历:
本科就读于山西农业大学生物信息学专业
硕士就读于山西大学生物化学与分子生物学专业
2012-2015年在山西大学攻读博士期间主要从事肿瘤分子生物学。
2015年7月留校工作以来,以M2型丙酮酸激酶(PKM2)为突破口,发现在大肠癌细胞中高表达PKM2可以促进大肠癌细胞迁移与粘附、促进大肠癌细胞炎症因子分泌及大肠癌细胞增殖、分泌型PKM2 可以促进大肠癌细胞迁移。PKM2可作为大肠癌转移和术后炎症反应诊治的靶点。在Cellular Signaling (两篇)、Biochemical and Biophysical Research Communications、RSC Advances、Asian Pacific Journal Of Cancer Prevention等杂志上发表SCI论文。
主要研究方向:
目前研究方向肿瘤转移、炎症微环境及分泌调控的机制研究。
目前研究方向:
1. PKM2在肿瘤炎症微环境中的作用机制
2.中药小分子靶向PKM2的分子机制研究
主要论文、著作
1. Peng Yang, Zongwei Li, Hanqing Li, Yangxu Lu, Haili Wu, Zhuoyu Li*. Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer. Cellular Signalling, 2015, 27, 1525-1532. IF: 4.315
2. Zongwei Li, Peng Yang, Zhuoyu Li*. The multifaceted regulation and functions of PKM2 in tumor progression. Biochimica et Biophysica Acta-Reviews on cancer, 2014, 1846, 285-296. IF: 9.433
3. Peng Yang, Zongwei Li, Rong Fu, Haili Wu, Zhuoyu Li*. Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling. Cellular Signalling, 2014, 26, 1853–1862. IF: 4.315
4. Peng Yang#, Zongwei Li#*, Lichao Zhang, Hanqing Li, Zhuoyu Li*. Analysis of metabonomic profiling alterations in a mouse model of colitis-associated cancer and 2-deoxy-D-glucose treatment. RSC Advances. 2016, 6, 58862. IF: 3.2
5. Peng Yang, Zongwei Li, Yingying Wang, Lichao Zhang, Haili Wu, Zhuoyu Li*. Secreted pyruvate kinase M2 facilitates cell migration via PI3K/Akt and Wnt/β-catenin pathway in colon cancer cells. Biochemical and Biophysical Research Communications, 2015, 459(2), 327-332. IF: 2.297
6. Peng Yang, Zhuoyu Li, Hanqing Li*. Potential Roles of Protease Inhibitors in Cancer Progression. Asian Pacific Journal of Cancer Prevention, 2016, 16 (18), 8047-8052. IF: 2.514
7. Rong Fu#, Peng Yang#, Haili Wu, Zongwei Li, Zhuoyu Li*. GRP78 secreted by colon cancer cells facilitates cell proliferation via PI3K/Akt signaling. Asian Pacific Journal of Cancer Prevention, 2014, 15 (17), 7245-7249. IF: 2.514
8. Haili Wu, Zongwei Li, Peng Yang, Lichao Zhang, Yongsheng Fan, Zhuou Li*. PKM2 depletion induces the compensation of glutaminolysis through β-catenin/c-Myc pathway in tumor cells. Cellular Signalling, 2014, 26, 2397-2405. IF: 4.315
9. Yanan Peng, Zongwei Li, Peng Yang, Ian P. Newton, Hua Ren, Lichao Zhang, Haili Wu, Zhuoyu Li*. Direct contacts with colon cancer cells regulate the differentiation of bone marrow mesenchymal stem cells into tumor associated fibroblasts. Biochemical and Biophysical Research Communications, 2014, 451, 68-73. IF: 2.297
10. Zongwei Li, Yingying Wang, Haili Wu, Lichao Zhang, Peng Yang, Zhuoyu Li. GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the β-catenin signaling. Oncotarget, 2014, 5(14): 5369-5380. IF: 6.359
11. 杨鹏, 李宗伟, 付荣, 李汉卿, 李卓玉. 丙酮酸激酶M1和M2的表达水平与结肠癌发展相关性研究. 山西大学学报(自然科学版)2014, 37(3): 447-453.
12. 杨鹏, 李艳琴. 荞麦黄酮和糖醇对胰脂肪酶的抑制作用. 食品科学, 2015, 11: 60-63.
主要科研项目
1. M2型丙酮酸激酶调控结肠癌细胞自噬的分子机制,山西省面上青年科技研究基金(201601D021107),2016年7月-2018年12月
2. 基于M型丙酮酸激酶可变剪接干预结肠癌细胞能量代谢的丹参酮IIA抗肿瘤机制研究,山西省高等学校科技创新项目(2016121),2016年1月-2018年12月
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