邢力 博士
	教授 博士生导师
	E-mail：LL638@email.sxu.edu.cn

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教育和工作经历

       扬州大学获硕士学位。中国科学院上海生物化学和细胞生物学研究所获理学博士学位。分别在加拿大传染病与国际疫苗研究中心和美国哈佛大学医学院微生物与免疫学系完成博士后训练。之后在麦吉尔大学主持研究解旋酶在艾滋病毒复制中的分子机理。目前在山西大学主持研究病毒性和细菌性传染病病原的复制分子机制和抗传染病疫苗的设计和免疫保护机理。

主要研究方向

 (1) 抗传染病疫苗的设计及其免疫保护机制的研究。

        疫苗(Vaccine)是一种生物制剂，可以诱导人体产生对特定感染性疾病的免疫保护。通常由弱化或杀死的微生物，或其毒素或其表面蛋白制成。该物质刺激人体的免疫系统，将其识别为威胁，并进一步识别和破坏其将来可能遇到的与该物质相关的任何微生物。疫苗可以预防或减轻自然病原体将来感染的影响。结核病(Tuberculosis，又称TB）为结核杆菌感染引起的疾病, 通常造成肺部感染，也会感染身体的其他部分。现阶段我们以斑马鱼和海鱼结核分枝杆菌为模型，研究结核杆菌的感染和免疫反应的分子机制，并设计研究针对结核病的有效疫苗。

(2) 炎症反应发生的分子机制及其在细菌感染中的作用。

       炎症反应(Inflammation)是人体组织对有害刺激物（例如病原体，受损细胞或刺激物）的复杂生物反应的一部分，是涉及免疫细胞,血管和分子介质的保护性反应，是先天性免疫的机制。炎症的功能是消除引起细胞损伤的最初原因，清除原始损伤和炎症过程中受损的坏死细胞和组织，并开始组织修复。因此炎症反应也是身体对抗病原微生物感染的重要关节。理解炎症反应的机制对研发抗感染药物至关重要。

美国专利

2004. BAV packaging regions and E1 transcriptional control regions. 专利号 US 7264818

代表性成果：

论文

1、RNA helicase A regulates replication of RNA viruses. Shi RZ, Pan YQ, Xing L*. Viruses. 2021 (*Corresponding author)

2、A single nucleotide distinguishes SARS-CoV-2 in Wuhan outbreak in December 2019 from that in Beijing Xinfadi in June 2020, China. Pan YQ#, Bahoussi AN#, Guo F#, Xing L*. New Microbes and New Infections. 2020 (*Corresponding author; #Equally contributed)

3、Current view on the helicase activity of RNA helicase A and its role in gene expression. Pan YQ, Xing L*.  Current Protein & Peptide Science. 2020 Nov 2. doi: 10.2174/1389203721666201103084122.  PMID: 33143622 (*Corresponding author)

4、Puzzling increase and decrease in COVID-19 cases in Pakistan. Shah PT, Xing L*. New Microbes and New Infections. 2020 Oct 17; doi: 10.1016/j.nmni.2020.100791. PMID: 33101693 (*Corresponding author)

5、RNA helicase A as co-factor for DNA viruses during replication. Guo F, Xing L*. Virus Research. 2021 Jan 2; 291:198206. doi: 10.1016/j.virusres.2020.198206. PMID: 33132162 (*Corresponding author)

6、Vaccination against Clostridium difficile by Use of an Attenuated Salmonella enterica Serovar Typhimurium    

Vector (YS1646) Protects Mice from Lethal Challenge. Winter K, Xing L, Kassardjian A, Ward BJ. Infection and Immunity. 2019 Jul 23;87(8): e00089-19. doi: 10.1128/IAI.00089-19. PMID: 31138615

7、STAT6 inhibitory peptide given during RSV infection of neonatal mice reduces exacerbated airway responses upon adult reinfection. Srinivasa BT, Restori KH, Shan J, Cyr L, Xing L, Lee S, Ward BJ, Fixman ED. Journal of Leukocyte Biology. 2017 Feb;101(2):519-529. doi: 10.1189/jlb.4A0215-062RR. PMID: 27566834

8、Role of the OB-fold of RNA helicase A in the synthesis of HIV-1 RNA. Xing L*, Niu M, Kleiman L*. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2014 Nov;1839(11):1069-78. doi: 10.1016/j.bbagrm.2014.08.008. PMID: 25149208 (*Corresponding author)

9、Helicase associated 2 domain is essential for helicase activity of RNA helicase A. Xing L*, Zhao X, Niu M, Kleiman L*. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 2014 Oct; 1844(10):1757-64. doi: 10.1016/j.bbapap.2014.07.001. PMID: 25062910 (*Corresponding author)

10、Different activities of the conserved lysine residues in the double-stranded RNA binding domains of RNA helicase A in vitro and in the cell. Xing L, Niu M, Zhao X, Kleiman L. Biochimica et Biophysica Acta (BBA) - General Subjects. 2014 Jul;1840(7):2234-43. doi: 10.1016/j.bbagen.2014.04.003. PMID: 24726449 (*Corresponding author)

11、Repetitive RNA unwinding by RNA helicase A facilitates RNA annealing. Koh HR, Xing L, Kleiman L, Myong S. Nucleic Acids Research. 2014 Jul;42(13):8556-64. doi: 10.1093/nar/gku523. PMID: 24914047

12、The role of A-kinase anchoring protein 95-like protein in annealing of tRNALys3 to HIV-1 RNA. Xing L*, Zhao X, Guo F, Kleiman L*. Retrovirology. 2014 Jul 17;11:58. doi: 10.1186/1742-4690-11-58. PMID: 25034436 (*Corresponding author)

13、Roles of the linker region of RNA helicase A in HIV-1 RNA metabolism. Xing L*, Niu M, Zhao X, Kleiman L*. PLoS One. 2013 Nov 6;8(11): e78596. doi: 10.1371/journal.pone.0078596. PMID: 24223160 (*Corresponding author)

14、In vitro and in vivo analysis of the interaction between RNA helicase A and HIV-1 RNA. Xing L, Niu M, Kleiman L. Journal of Virology. 2012 Dec;86(24):13272-80. doi: 10.1128/JVI.01993-12. Epub 2012 Sep 26. PMID: 23015696

15、cis-Acting effects on RNA processing and Drosha cleavage prevent Epstein-Barr virus latency III BHRF1 expression. Xing L*, Kieff E*. Journal of Virology. 2011 Sep;85(17):8929-39. doi: 10.1128/JVI.00336-11. PMID: 21697496 (*Corresponding author)

16、Coordinate roles of Gag and RNA helicase A in promoting the annealing of formula to HIV-1 RNA. Xing L, Liang C, Kleiman L. Journal of Virology. 2011 Feb;85(4):1847-60. doi: 10.1128/JVI.02010-10. PMID: 21106734

17、Packaging of viral RNAs in virions of adenoviruses. Xing L, Tikoo SK. Virology Journal. 2009 Feb 5; 6:16. doi: 10.1186/1743-422X-6-16. PMID: 19196470

18、Epstein-Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication. Xing L, Kieff E. Journal of Virology. 2007 Sep;81(18):9967-75. doi: 10.1128/JVI.02244-06. PMID: 17626073

19、Epstein-Barr virus and virus human protein interaction maps. Calderwood MA, Venkatesan K, Xing L, Chase MR, Vazquez A, Holthaus AM, Ewence AE, Li N, Hirozane-Kishikawa T, Hill DE, Vidal M, Kieff E, Johannsen E. Proc Natl Acad Sci USA. 2007 May 1;104(18):7606-11. doi: 10.1073/pnas.0702332104. PMID: 17446270

20、Bovine adenovirus-3 E1A coding region contain cis-acting DNA packaging motifs. Xing L, Tikoo SK. Virus Research. 2007 Dec;130(1-2):315-20. doi: 10.1016/j.virusres.2007.06.015. PMID: 17683823

21、E1A promoter of bovine adenovirus type 3. Xing L, Tikoo SK. Journal of General Virology. 2006 Dec;87(Pt 12):3539-3544. doi: 10.1099/vir.0.82108-0. PMID: 17098968

22、Promoter activity of left inverted terminal repeat and downstream sequences of porcine adenovirus type 3. Xing L, Tikoo SK. Virus Research. 2005 Apr;109(1):51-8. doi: 10.1016/j.virusres.2004.10.006. PMID: 15826912

23、Porcine adenovirus type 3 E1 transcriptional control region contains a bifunctional regulatory element. Xing L, Tikoo SK. Virology. 2004 Jan 5;318(1):37-44. doi: 10.1016/j.virol.2003.09.040. PMID: 14972533

24、cis-Acting packaging motifs of porcine adenovirus type 3. Xing L, Tikoo SK. Virus Research. 2004 Sep 1;104(2):207-14. doi: 10.1016/j.virusres.2004.04.007. PMID: 15246658

25、Viral RNAs detected in virions of porcine adenovirus type 3. Xing L, Tikoo SK. Virology. 2004 Apr 10;321(2):372-82. doi: 10.1016/j.virol.2003.12.025. PMID: 15051396

26、Identification of cis-acting sequences required for selective packaging of bovine adenovirus type 3 DNA. Xing L, Zhang L, Kessel JV, Tikoo SK. Journal of General Virology. 2003 Nov;84(Pt 11):2947-2956. doi: 10.1099/vir.0.19418-0. PMID: 14573799

27、Characterization of cis-acting sequences involved in packaging porcine adenovirus type 3. Xing L, Tikoo SK. Virology. 2003 Sep 30;314(2):650-61. doi: 10.1016/s0042-6822(03)00493-8. PMID: 14554092

28、Adenovirus mediated expression of anti-sense pig alpha (1,3) galactosyltransferase or human secretor type alpha (1,2) fucosyltransferase reduces level of Gal alpha (1,3) Gal epitope on NIH3T3 cells. Xing L, Xia GH, Bai XF, Fei J, and Guo LH. 2001. Xenotransplantation. 8 (supplement1).

29、Adenovirus-mediated expression of pig alpha (1, 3) galactosyltransferase reconstructs Gal alpha (1, 3) gal epitope on the surface of human tumor cells. Xing L, Xia GH, Fei J, Huang F, Guo LH. Cell Research. 2001 Jun;11(2):116-24. doi: 10.1038/sj.cr.7290076. PMID: 11453543

30、FUT2 gene involved in expression of H blood group antigen on surface of human tumor cell lines BEL-7404, SGC-7901, and SPC-A-1. Xing L, Guo LH. Acta Pharmacologica Sinica. 2000 Nov;21(11):997-1001. PMID: 11501068

31、Adenovirus-mediated expression of antisense RNA transcripts complementary to pig alpha (1,3) galactosyltransferase mRNA inhibits expression of Gal alpha (1,3) Gal epitope. Xing L, Xia GH, Bai XF, Fei J, Guo LH. Acta Pharmacologica Sinica. 2000 Nov;21(11):1005-10. PMID: 11501054

32、Adenovirus-mediated expression of human secretor type alpha (1,2) fucosyltransferase reduces level of Gal alpha (1,3) Gal epitope. Xing L, Xia GH, Fei J, Bai XF, Guo LH. Acta Pharmacologica Sinica. 2000 Sep;21(9):807-13. PMID: 11501162

33、A recombinant fowlpox virus vaccine expressing glycoprotein B gene from CVI988/Rispens strain of MDV: protection studies in different chickens. Liu X, Peng D, Wu X, Xing L, Zhang R. Acta Virologica. 1999 Apr-Jun;43(2-3):201-4. PMID: 10696446

34、Cloning of glycoprotein B gene from strain Rispens of Marek's disease virus and construction of recombinant fowlpox virus. Xing L, Peng D, Zhu A, Liu X, Zhang R. Acta Microbiologica Sinica. 1999 Apr;39(2):164-7. PMID: 12555423.

35、Angiostatin的分离纯化及对B16黑色素瘤的抑制作用。 夏国宏, 卢卫新, 殷国勇, 葛锡锐, 费俭, 邢力, 郭礼和。《中国肿瘤生物治疗杂志》1999, 6 (4): 280-283. DOI:10.3872/j.issn.1007-385X.1999.4.011。

36、表达Angiostatin基因的B16黑色素瘤体内抑制作用。 夏国宏, 卢卫新, 邢力, 费俭, 郭礼和。《中国肿瘤生物治疗杂志》1999, 6(4): 284-287. DOI:10.3872/j.issn.1007-385X.1999.4.012。

37、人Fas-L基因的克隆和表达。夏国宏, 邢力, 郭礼和。《上海免疫学杂志》1999年 第4期 213-215页。

38、异种器官移植中的Gal α(1,3) Gal抗原表位的研究进展。邢力, 郭礼和 。《细胞生物学杂志》2001年 第4期 191-195页。

39、利用人的天然抗体抗肿瘤。邢力, 郭礼和。《中国肿瘤生物治疗杂志》2001年 第1期 67-69页。

GenBank 发布的基因序列

1、 2013，HIV-1 from Canada exon 6D spliced transcript variant 1 mRNA sequence; and tat fusion protein mRNA, partial cds；GenBank accession number: KC493108.1

2、2013，HIV-1 from Canada exon 6D spliced transcript variant 2 mRNA sequence; and tat fusion protein mRNA, partial cds；GenBank accession number: KC493109.1

3、2013，HIV-1 from Canada exon 6D spliced transcript variant 3 mRNA sequence；GenBank accession number: KC493110.1

4、2013，HIV-1 from Canada exon 6D spliced transcript variant 4 mRNA sequence；GenBank accession number: KC493111.1

5、2013，HIV-1 from Canada exon 6D spliced transcript variant 5 mRNA sequence；GenBank accession number: KC493112.1

6、2013，HIV-1 from Canada exon 6D spliced transcript variant 6 mRNA sequence；GenBank accession number: KC493113.1

7、2006，Human herpesvirus 4 strain Akata BHRF1 gene, complete cds；GenBank accession number: EF192979.1