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教授
首页» 人才队伍» 教授
董丽
董丽   博士
教授   博士生导师
Email:Dongli@sxu.edu.cn

教育背景

1997/09-2002/07 沈阳医学院  医学学士学位

2002/09-2005/07 天津医科大学  医学硕士学位

2014/09-2017/07 北京协和医学院 中国医学科学院肿瘤医院 医学博士学位

工作经历

2019/01-2021/09 挪威癌症研究所/奥斯陆大学 博士后

2017/07至今 山西大学 副教授

2005/08-2014/07 中国辐射防护研究院 助理研究员、副研究员

主要研究方向

主要致力于感染性相关疾病的发病机制与控制策略,侧重宫颈癌、食管癌和结核病的病因学、早期诊断和早期治疗分子标志物研究。具体方向为

1. 外泌体miRNA和蛋白与免疫微环境在宫颈癌发病过程中的作用;

2. HPV病毒甲基化和宿主甲基化在预测宫颈癌发病风险中的作用;

3. 间充质干细胞在耐药性结核病中的免疫调控作用研究;

4. 消化道微生物基因组在食管癌形成中的预警机制。

近5年主持科研项目

1. 国家自然科学基金(面上项目):外泌体HMGB1通过调控免疫微环境促进宫颈癌变的作用研究,2023-2026,主持,在研

2. 国家自然科学基金(青年项目):外泌体细胞粘附相关膜蛋白与宫颈癌发病风险的队列研究,2019-2021,主持,结题

3. 山西省科技厅重点研发计划:间充质干细胞用于耐药性结核病治疗的关键技术研究,2022-2025,主持,在研

4. 山西省卫健委“四个一批”科技创新项目:间充质干细胞在抗耐药性结核中的免疫调控作用研究,2021-2023,主持,在研

5. 山西省回国人员专项:外泌体miR-21在宫颈癌形成中的作用及机制研究,2021-2022,主持,在研

6. 山西省高等学校科技创新项目,外泌体膜蛋白在HPV感染向宫颈癌进展中的用及其应用于宫颈癌筛查的研究,2019-2021,主持,结题

7. 山西省自然科学基金(面上项目):外泌体Survivin蛋白在HPV感染者宫颈病变进展中的作用研究,2018-2020,主持,结题

近5年代表性论文

1. Dong L, Nygård M, Nathalie CS, Ole K, Hansen BT. Real-world effectiveness of HPV vaccination against cervical neoplasia among birth cohorts ineligible for routine vaccination. Int J Cancer, 2022.

2. Dong L, Nygård M, Hansen BT. Sociodemographic Correlates of Human Papillomavirus Vaccine Uptake: Opportunistic and Catch-Up Vaccination in Norway. Cancers, 2021, 13(3483): 1-13.

3. Yang C, Ma X, Dong L. Low serum calcium and phosphorus and their clinical performance in detecting COVID-19 patients. J Med Virol. 2021,93(3):1639-1651.(corresponding author)

4. Ma XX, Ge A, Han J. Metaanalysis of downregulated Ecadherin as a diagnostic biomarker for cervical cancer. Archives of Gynecology and Obstetrics,2021,1(13):14-24. (corresponding author)

5. Han J, Ning P, Dong L. Association of polymorphisms of innate immunity-related genes and tuberculosis susceptibility in Mongolian population. Human Immunology, 2021 Feb(corresponding author)

6. Zhang SS, Dong L, Wang GM, et al. Progressive liver injury and increased mortality risk in COVID-19 patients: A retrospective cohort study in China. World J Gastroenterol, 2021,27(9): 835-853. (co-first author)

7. Dong L, Zhang L, Hu SY, et al. Risk stratification of HPV 16 DNA methylation combined with E6 oncoprotein in cervical cancer screening: a ten-year prospective cohort study. Clinical Epigenetics,2020,3(1):1-8

8. Yin J, Dong L, Zhao J, et al. Composition and consistence of the bacterial microbiome in upper, middle and lower esophagus before and after Lugol’s iodine staining in the esophagus cancer screening. Scandinavian Journal of Gastroenterology, 2020, 55(12): 1467-1474. (co-first author)

9. Dong L, Li T, Li L, et al. Clustering patterns of type-type combination in multiple genotypes infections of human papillomavirus in cervical adenocarcinoma. Journal of Medical Virology,2019, 91(11):2001-2008.

10. Dong L, Yin J, Zhao J, et al. Microbial Similarity and Preference for Specific Sites in Healthy Oral Cavity and Esophagus. Frontier in Microbiology, 2018, 9:1603.

11. Dong L, Wang M, Zhao XL, et al. Human papillomavirus viral load as a useful tool for non-16/18 high-risk human papillomavirus positive women: a prospective screening cohort study. Gynecologic Oncology, 2018, 148(1):103-110.

12. Dong L, Hu SY, Zhang Q, et al. Risk prediction of cervical cancer and precancers by type-specific human papillomavirus: evidence from a population-based cohort study in China. Cancer Prevention Research, 2017,10(12):745-751.

13. Dong L, Lin CQ, Li L, et al. An evaluation of clinical performance of FTA cards for HPV 16/18 detection using cobas 4800 HPV Test compared to dry swab and liquid medium[J]. Journal of Clinical Virology, 2017, 94(8):67-71.

14. Dong L, Feng RM, Zhang LX, et al. Prospective comparison of hybrid capture 2 and SPF10-LiPA for carcinogenic human papillomavirus detection and risk prediction of cervical cancer: a population-based cohort study in China. Journal of gynecologic oncology, 2017, 28(5): e66.

15. Zhang Q, Dong L, Hu SY, et al. Risk Stratification and Long-term Risk Prediction of E6 Oncoprotein in a Prospective Screening Cohort in China. International Journal of Cancer, 2017, 141(6):1110-1119.







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